Elasto-plastic Analysis of High-strength Concrete Shear Wall with Boundary Columns Using Fiber Model

In this study, an experimental study and numerical calculations using fiber model were conducted for four high-strength concrete shear walls with boundary columns under low cyclic load. The boundary column and shear wall were divided into fiber elements, and PERFORM-3D finite element analysis software was used to carry out push-over analysis on the test specimens. The results show that the finite element analysis results were in good agreement with the experimental results. The proposed analysis method could perform elasto-plastic analysis on the high-strength concrete shear wall with boundary columns without distinguishing the categories of frame column and shear wall. The seismic performance of high-strength concrete shear wall with boundary columns was analyzed using the following parameters: axis compression ratio, height to width ratio, ratio of vertical reinforcement, and ratio of longitudinal reinforcement in the boundary column. The results show that the increase in the axial compression ratio causes the bearing capacity of the shear wall to increase at first and then to decrease and causes the ductility to decrease. The increase in the height to width ratio causes the bearing capacity of the shear wall to decrease and its ductility to increase. The ratio of vertical reinforcement was found to have little effect on the bearing capacity and ductility. The increase in the ratio of longitudinal reinforcement in boundary column resulted in a significant increase in the bearing capacity and caused the ductility to decrease at first and then to slowly increase

Clinical efficacy of Danshen preparation in the treatment of vascular cognitive impairment: A systematic review and meta-analysis

Ethnopharmacological relevanceDanshen preparations are widely used in the treatment of ischaemic cerebrovascular disease. However, the clinical efficacy of such preparations remains unclear. Consequently, Danshen preparations are used to a lesser extent in vascular cognitive impairment (VCI).Aim of the studyIn this study, we aimed to systematically assess the clinical efficacy and safety of Danshen preparations in VCI. To this end, we examined and performed a meta-analysis (MA) of the evidence available from randomised controlled trials (RCTs) of Danshen preparations conducted in patients with VCI.MethodsWe queried the following sources and collected all articles reporting on RCTs of Danshen preparations published prior to December 2021: PubMed, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chongqing VIP Database (CQVIP), and China Biology Medicine (CBM) disc databases. The assessment of treatments that were included in references were performed by RevMan 5.2 software based on guidelines from Cochrane Handbook for Systematic Reviews of Interventions.ResultsWe included a total of 12 RCTs that included data on clinical therapeutic effects. The evaluation criteria included the following: National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI), Mini-Mental State Assessment (MMSE), Montreal Cognitive Assessment (MOCA), Activities of Daily Living Scale (ADL), treatment effect index, and incidence of adverse reaction index. In the included studies, the observation groups included 656 cases and the control groups included 660 cases. The results of the MA were as follows: the mean difference (MD) value after combining the effect size for NIHSS was −2.91, with a 95% confidence interval (CI) of −4.22 to −1.59; the combined effect quantity hypothesis test revealed that Z = 4.33 (p < 0.00001), indicating that the score pertaining to the degree of neurological deficit (NIHSS) in the observation group after treatment was significantly lower than that in the control group. This result reveals that treatment with a Danshen preparation can reduce neurological deficit in VCI patients. The MD value after combining the effect size for mRS was −0.73, with a 95% CI of −0.85 to −0.61; the result of the combined effect quantity hypothesis test revealed that Z = 12.29 (p < 0.00001). These results indicate that the degree of disability was significantly reduced after treatment in the observation group. The MD value after combining the effect size for MMSE was 2.09, with a 95% CI of 0.33–3.84; the result of the combined effect quantity hypothesis test showed that Z = 2.33 (p = 0.02). These results indicate that the cognitive function score (MMSE) of the observation group after treatment was significantly higher than that of the control group and suggests that the cognitive function of VCI patients was improved after treatment with Danshen preparations. The MD value after combining the effect size for ADL was 8.79, with a 95% CI of 3.52 to 14.06; the result of the combined effect quantity hypothesis test indicated that Z = 3.27 (p = 0.001). These results showed that the life ability (ADL scale) scores of patients in the observation group after treatment were significantly higher than those in the control group, and reveals that after treatment with Danshen preparations, patients exhibited significant improvement in life ability. The MD value after combining the effect size for high-sensitivity C-reactive protein (hs-CRP) was −3.21, with a 95% CI of −4.21 to −2.22; the result of the combined effect quantity hypothesis test showed that Z = 6.31 (p < 0.00001), indicating that the hs-CRP level in the observation group was significantly decreased after treatment. The MD value after combining the effect size for interleukin (IL)-6 was −2.95, with a 95% CI of −3.86 to −2.04; the result of the combined effect quantity hypothesis test showed that Z = 6.36 (p < 0.00001). These results showed that the IL-6 level in the observation group was significantly decreased after treatment.ConclusionThe existing clinical evidence shows that Danshen preparations exert significant therapeutic effects on VCI patients and can ameliorate inflammatory conditions in these patients. In addition, Danshen preparations are relatively safe

Yanghe Decoction Suppresses the Experimental Autoimmune Thyroiditis in Rats by Improving NLRP3 Inflammasome and Immune Dysregulation

Inflammation is an important contributor to autoimmune thyroiditis. Yanghe decoction (YH) is a traditional Chinese herbal formulation which has various anti-inflammatory effects. It has been used for the treatment of autoimmune diseases such as ankylosing spondylitis In this study we aimed to investigate the effects of YH on autoimmune thyroiditis in a rat model and elucidate the underlying mechanisms. The experimental autoimmune thyroiditis (EAT) model was established by thyroglobulin (pTG) injections and excessive iodine intake. Thyroid lesions were observed using hematoxylin and eosin (H and E) staining and serum TgAb, TPOAb, TSH, T3, and T4 levels were measured by enzyme-linked immunosorbent assay IL-35 levels were evaluated using real-time polymerase chain reaction (RT-PCR) and Th17/Treg balance in peripheral blood mononuclear cells (PBMCs) was determined by flow cytometry and RT-PCR. Changes in Wnt/β-catenin signaling were evaluated using Western blot. Immunofluorescence staining and western blot were employed to examine NLRP3 inflammasome activation in the thyroid. YH minimized thyroid follicle injury and decreased concentrations of serum TgAb, TPOAb, TSH, T3, and T4 in EAT model. The mRNA of IL-35 was increased after YH treatment. YH also increased the percentage of Treg cells, and decreased Th17 proportion as well as Th17/Treg ratio in PBMCs. Meanwhile, the mRNA levels of Th17 related cytokines (RORγt, IL-17A, IL-21, and IL-22) were suppressed and Treg related cytokines (FoxP3, TGF-β, and IL-10) were promoted in PBMCs. Additionally, the protein expressions of Wnt-1 and β-catenin were unregulated after YH treatment. NLRP3 immunostaining signal and protein levels of IL-17, p-NF-κB, NLRP3, ASC, cleaved-Caspase-1, cleaved-IL-1β, and IL-18 were downregulated in the thyroid after YH intervention. Overall, the present study demonstrated that YH alleviated autoimmune thyroiditis in rats by improving NLRP3 inflammasome and immune dysregulation

Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics

Background: Intrahepatic cholestasis (IC) is a disorder of bile production, secretion, and excretion with various causes. Crocin I (CR) is effective in the treatment of IC, but its underlying mechanisms need to be further explored. We aimed to reveal the therapeutic mechanism of crocin I for IC by combining an integrated strategy of metabolomics and transcriptomics.Methods: The hepatoprotective effect of CR against cholestasis liver injury induced by α-naphthylisothiocyanate (ANIT) was evaluated in rats. The serum biochemical indices, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA), total bilirubin (TBIL), direct bilirubin (DBIL), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β), as well as the liver oxidative stress indexes and the pathological characteristics of the liver were analyzed. In addition, we also performed a serum metabolomics study using UPLC-Q Exactive HF-X technology to investigate the effect of CR on the serum of rats with ANIT-induced IC and screened potential biomarkers. The enrichment analysis of differential expressed genes (DEGs) was performed by transcriptomics. Finally, the regulatory targets of CR on potential biomarkers were obtained by combined analysis, and the relevant key targets were verified by western blotting.Results: CR improved serum and liver homogenate indexes and alleviated liver histological injury. Compared with ANIT group, the CR group had 76 differential metabolites, and 10 metabolic pathways were enriched. There were 473 DEGs significantly changed after CR treatment, most of which were enriched in the retinol metabolism, calcium signaling pathway, PPAR signaling pathway, circadian rhythm, chemokine signaling pathway, arachidonic acid metabolism, bile secretion, primary bile acid biosynthesis, and other pathways. By constructing the “compound-reaction-enzyme-gene” interaction network, three potential key-target regulation biomarkers were obtained, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), ATP-binding cassette transporter G5 (ABCG5), and sulfotransferase2A1(SULT2A1), which were further verified by western blotting. Compared with the ANIT group, the CR group significantly increased the expression of ABCG5 and SULT2A1, and the expression of HMGCR significantly decreased.Conclusion: Combined metabolomic and transcriptomic analyses show that CR has a therapeutic effect on IC through regulation of the biosynthesis of bile acids and bilirubin in the bile secretion pathway and regulation of the expression of HMGCR, ABCG5, and SULT2A1

Quantitative MRI evaluation of articular cartilage in patients with meniscus tear

PurposeThe aim of this study was to assess quantitatively articular cartilage volume, thickness, and T2 value alterations in meniscus tear patients.Materials and methodsThe study included 32 patients with meniscus tears (17 females, 15 males; mean age: 40.16 ± 11.85 years) and 24 healthy controls (12 females; 12 males; mean age: 36 ± 9.14 years). All subjects were examined by 3 T magnetic resonance imaging (MRI) with 3D dual-echo steady-state (DESS) and T2 mapping images. All patients underwent diagnostic arthroscopy and treatment. Cartilage thickness, cartilage volume and T2 values of 21 subregions of knee cartilage were measured using the prototype KneeCaP software (version 2.1; Siemens Healthcare, Erlangen, Germany). Mann-Whitney-U tests were utilized to determine if there were any significant differences among subregional articular cartilage volume, thickness and T2 value between patients with meniscus tear and the control group.ResultsThe articular cartilage T2 values in all subregions of the femur and tibia in the meniscus tear group were significantly higher (p< 0.05) than in the healthy control group. The cartilage thickness of the femoral condyle medial, femur trochlea, femur condyle lateral central, tibia plateau medial anterior and patella facet medial inferior in the meniscus tear group were slightly higher than in the control group (p< 0.05). In the femur trochlea medial, patella facet medial inferior, tibia plateau lateral posterior and tibia plateau lateral central, there were significant differences in relative cartilage volume percentage between the meniscus tear group and the healthy control group (p< 0.05). Nineteen patients had no cartilage abnormalities (Grade 0) in the meniscus tear group, as confirmed by arthroscopic surgery, and their T2 values in most subregions were significantly higher (p< 0.05) than those of the healthy control group.ConclusionThe difference in articular cartilage indexes between patients with meniscus tears and healthy people without such tears can be detected by using quantitative MRI. Quantitative T2 values enable early and sensitive detection of early cartilage lesions

Privacy Protection of Sensitive Bioinformation Based on Event Cameras

进入大数据时代后，互联网应用和信息服务全面普及，大量的个人敏感生物信息被收集整理，导致隐私泄露风险增加；事件相机作为新型的生物启发式传感器，具有低延迟、高动态、无纹理等特性，可为解决数据端隐私保护问题提供全新的技术途径，也因其光敏工作原理而适用于家庭监控等私人场景。本文从大数据时代的隐私泄露问题、事件相机在隐私保护中的优势两方面，深入分析了事件相机用于隐私保护的研究背景；系统梳理了基于人脸模板的隐私保护、基于去识别的隐私保护、基于点云混沌加密的隐私保护等传统的敏感生物信息隐私保护方法，包括行人重识别、手势识别、面部分析在内的面向隐私保护的事件感知方法以及两大类方法的研究进展。进一步总结了强度图像重建、图像修复、视频重建等基于事件流的图像重建与修复新进展，完成了基于6 种算法的图像重建及其结果分析，证明已有重建算法对纹理信息的恢复能力有限，反向验证了基于事件相机的隐私保护技术可行性。针对事件相机未来的规模化应用，提出了降低硬件成本、改进算法网络、从市场角度推动等发展建议，以期为事件相机的隐私保护深化应用提供基础参考

Protective mechanism of nicorandil on rat myocardial ischemia-reperfusion

OBJECTIVES: To study the protective mechanism of nicorandil on myocardial ischemia-reperfusion injury. METHODS: Fifty rats were randomly divided into five groups, four of which were operated on to produce myocardial ischemia-reperfusion. Nicorandil (5mg/kg) was administrated by intravenous injection to three of the groups. The myocardial ultrastructure was observed by electron microscope. The expression levels of the antiapoptotic protein Bcl-2 and the pro-apoptotic protein Bax were detected by immunohistochemical staining with rhodamine 123. The mitochondrial membrane potential was detected by spectrophotometry. RESULTS: The activity of lactate dehydrogenase (LDH) and malondialdehyde (MDA) content was decreased and the activity of superoxide dismutase (SOD) was increased in the three nicorandil groups, compared with those in the group without nicorandil (

Model Construction and System Design of Natural Grassland-Type Recognition Based on Deep Learning

As an essential basic function of grassland resource surveys, grassland-type recognition is of great importance in both theoretical research and practical applications. For a long time, grassland-type recognition has mainly relied on two methods: manual recognition and remote sensing recognition. Among them, manual recognition is time-consuming and laborious, and easily affected by the level of expertise of the investigator, whereas remote sensing recognition is limited by the spatial resolution of satellite images, and is not suitable for use in field surveys. In recent years, deep learning techniques have been widely used in the image recognition field, but the application of deep learning in the field of grassland-type recognition needs to be further explored. Based on a large number of field and web-crawled grassland images, grassland-type recognition models are constructed using the PyTorch deep learning framework. During model construction, a large amount of knowledge learned by the VGG-19 model on the ImageNet dataset is transferred to the task of grassland-type recognition by the transfer learning method. By comparing the performances of models with different initial learning rates and whether or not data augmentation is used, an optimal grassland-type recognition model is established. Based on the optimal model, grassland resource-type map, and meteorological data, PyQt5 is used to design and develop a grassland-type recognition system that uses user-uploaded grassland images and the images’ location information to comprehensively recognize grassland types. The results of this study showed that: (1) When the initial learning rate was set to 0.01, the model recognition accuracy was better than that of the models using initial learning rates of 0.1, 0.05, 0.005, and 0.001. Setting a reasonable initial learning rate helps the model quickly reach optimal performance and can effectively avoid variations in the model. (2) Data augmentation increases the diversity of data, reducing the overfitting of the model; recognition accuracies of the models constructed using the augmented data can be improved by 3.07–4.88%. (3) When the initial learning rate was 0.01, modeling with augmented data and with a training epoch = 30, the model performance reached its peak—the TOP1 accuracy of the model was 78.32% and the TOP5 accuracy of the model was 91.27%. (4) Among the 18 grassland types, the recognition accuracy of each grassland type reached over 70.00%, and the probability of misclassification among most of the grassland types was less than 5.00%. (5) The grassland-type recognition system incorporates two reference grassland types to further improve the accuracy of grassland-type recognition; the accuracy of the two reference grassland types was 72.82% and 75.01%, respectively. The recognition system has the advantages of convenient information acquisition, good visualization, easy operation, and high stability, which provides a new approach for the intelligent recognition of grassland types using grassland images taken in a field survey