Utilization of polysaccharides as depressants for the flotation separation of copper/lead concentrate

The interaction mechanism between dextrin and minerals has been investigated through micro-flotation, adsorption density measurements, Fourier transform infrared ray (FTIR) spectroscopic studies and dissolution tests. Dextrin shows a good depressing action towards galena but not chalcopyrite. FTIR spectroscopic studies indicate that dextrin chemically adsorbed on galena surface in alkaline pH range. Dissolution tests confirm leaching action of metal ions from chalcopyrite and galena surfaces, and dextrin-lead ion interaction. Adsorption measurements present that the higher adsorption density of O-isopropyl-N-ethyl thionocarbamate (IPETC) onto chalcopyrite than that onto galena, and IPETC adsorbed on galena decrease with increasing dextrin concentrations in the presence of dextrin, attesting the flotation results

The Hippo signaling pathway: from multiple signals to the hallmarks of cancers

Evolutionarily conserved, the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis. The activity of this pathway is tightly regulated under normal circumstances, since its physical function is precisely maintained to control the rate of cell proliferation. Failure of maintenance leads to a variety of tumors. Our understanding of the mechanism of Hippo dysregulation and tumorigenesis is becoming increasingly precise, relying on the emergence of upstream inhibitor or activator and the connection linking Hippo target genes, mutations, and related signaling pathways with phenotypes. In this review, we summarize recent reports on the signaling network of the Hippo pathway in tumorigenesis and progression by exploring its critical mechanisms in cancer biology and potential targeting in cancer therapy