The impact of the digital economy on young people’s consumption in the context of the new coronary pneumonia epidemic

This paper analyzes digital economy data from Beijing and 1 Chinese province and city by a panel model and a fixed impact model. The findings are as follows: First, the development of digital participatory finance has positively influenced China’s consumption level, consumption structure, consumption areas and development, mainly because it has affected the consumer goods of Chinese citizens. Second, by analyzing digital economy indicators and data at different stages of economic development, it is believed that the size and reach of the digital economy will have a more positive impact on per capita consumption in China. China’s digital economy mainly affects the urban-rural structure, regional structure, and consumption habits of residents to realize the impact of the digital economy. The digital economy has a much greater impact on growth-oriented household consumption than on household consumption. Based on the findings, recommendations for action are also provided. The government should strengthen digital infrastructure, improve digital economy products and derivative financial services, improve the quality of current financial services for citizens, and increase the affordability of citizens to successfully develop the digital economy

Molecular Dynamics Simulation of Ligand Dissociation from Liver Fatty Acid Binding Protein

The mechanisms of how ligands enter and leave the binding cavity of fatty acid binding proteins (FABPs) have been a puzzling question over decades. Liver fatty acid binding protein (LFABP) is a unique family member which accommodates two molecules of fatty acids in its cavity and exhibits the capability of interacting with a variety of ligands with different chemical structures and properties. Investigating the ligand dissociation processes of LFABP is thus a quite interesting topic, which however is rather difficult for both experimental approaches and ordinary simulation strategies. In the current study, random expulsion molecular dynamics simulation, which accelerates ligand motions for rapid dissociation, was used to explore the potential egress routes of ligands from LFABP. The results showed that the previously hypothesized “portal region” could be readily used for the dissociation of ligands at both the low affinity site and the high affinity site. Besides, one alternative portal was shown to be highly favorable for ligand egress from the high affinity site and be related to the unique structural feature of LFABP. This result lends strong support to the hypothesis from the previous NMR exchange studies, which in turn indicates an important role for this alternative portal. Another less favored potential portal located near the N-terminal end was also identified. Identification of the dissociation pathways will allow further mechanistic understanding of fatty acid uptake and release by computational and/or experimental techniques