1,915 research outputs found
A Method against Interrupted-Sampling Repeater Jamming Based on Energy Function Detection and Band-Pass Filtering
Interrupted-sampling repeater jamming (ISRJ) is a new kind of coherent jamming to the large time-bandwidth linear frequency modulation (LFM) signal. Many jamming modes, such as lifelike multiple false targets and dense false targets, can be made through setting up different parameters. According to the āstorage-repeater-storage-repeaterā characteristics of the ISRJ and the differences in the time-frequency-energy domain between the ISRJ signal and the target echo signal, one new method based on the energy function detection and band-pass filtering is proposed to suppress the ISRJ. The methods mainly consist of two parts: extracting the signal segments without ISRJ and constructing band-pass filtering function with low sidelobe. The simulation results show that the method is effective in the ISRJ with different parameters
Pleckstrin Homology (PH) Domain Leucine-Rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C
The proper establishment of epithelial polarity allows cells to sense and respond to signals that arise from the microenvironment in a spatiotemporally controlled manner. Atypical PKCs (aPKCs) are implicated as key regulators of epithelial polarity. However, the molecular mechanism underlying the negative regulation of aPKCs remains largely unknown. In this study, we demonstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP), a novel family of Ser/Thr protein phosphatases, plays an important role in regulating epithelial polarity by controlling the phosphorylation of both aPKC isoforms. Altered expression of PHLPP1 or PHLPP2 disrupted polarization of Caco2 cells grown in 3D cell cultures as indicated by the formation of aberrant multi-lumen structures. Overexpression of PHLPP resulted in a decrease in aPKC phosphorylation at both the activation loop and the turn motif sites; conversely, knockdown of PHLPP increased aPKC phosphorylation. Moreover, in vitro dephosphorylation experiments revealed that both aPKC isoforms were substrates of PHLPP. Interestingly, knockdown of PKCĪ¶, but not PKCĪ¹, led to similar disruption of the polarized lumen structure, suggesting that PKCĪ¶ likely controls the polarization process of Caco2 cells. Furthermore, knockdown of PHLPP altered the apical membrane localization of aPKCs and reduced the formation of aPKC-Par3 complex. Taken together, our results identify a novel role of PHLPP in regulating aPKC and cell polarity
ImaginE: An Imagination-Based Automatic Evaluation Metric for Natural Language Generation
Automatic evaluations for natural language generation (NLG) conventionally
rely on token-level or embedding-level comparisons with text references. This
differs from human language processing, for which visual imagination often
improves comprehension. In this work, we propose ImaginE, an imagination-based
automatic evaluation metric for natural language generation. With the help of
StableDiffusion, a state-of-the-art text-to-image generator, we automatically
generate an image as the embodied imagination for the text snippet and compute
the imagination similarity using contextual embeddings. Experiments spanning
several text generation tasks demonstrate that adding machine-generated images
with our ImaginE displays great potential in introducing multi-modal
information into NLG evaluation, and improves existing automatic metrics'
correlations with human similarity judgments in both reference-based and
reference-free evaluation scenarios.Comment: EACL 202
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