Heave Motion Measurement by Adaptive Filter Based on Longuet-Higgins Wave Model

A method is proposed to obtain heave motion information based on the Longuet-Higgins wave model. The Longuet-Higgins wave model which is closer to the sea wave is introduced. Based on it, random process of the noise is analyzed and the highpass filter is designed to reduce errors. Then it is the key point in this article that an adaptive algorithm is put forward because of the complexity of the waves. The algorithm adjusts the cutoff frequency to reduce the amplitude attenuation of the filter by analyzing the wave. For the same reason the comprehensive parameter of the phase compensation can be also obtained by the algorithm. Simulation measurement results show that under the rough sea situation the maximum value of absolute error is 0.4942 m according to the normal method, the method is 0.1170 m, and the average error ratio of the rough sea test reduces to 3.89% from 12.54%, which demonstrates that the adaptive filter is more effective in measuring heave movement. A variety of simulation cases show that the adaptive filter can also improve the precision of the heave motion under different sea situations

Season 2, Episode 4: An Appreciative Inquiry Narrative

Laël Ngangmeni (\u2723, MD/PhD) and Dr. Hugh Silk are joined by Ken Peterson, a family nurse practitioner and assistant professor in the Graduate School of Nursing, to reflect on his experience as a nurse during the HIV/AIDS epidemic. Recorded August 2021. Ken Peterson\u27s piece An Appreciative Inquiry Narrative and the transcript for this episode are available for download as additional files

Season 2, Episode 2: Check Engine Light

Qiuwei Yang (\u2722) and Jesse Sardell (\u2724) are joined by pediatrician Dr. Heather Finlay-Morreale to discuss her experience of being diagnosed with a chronic illness and how that has influenced the way she cares for her own patients. Recorded April 2021. Dr. Finlay-Morreale\u27s piece Check Engine Light was first published in JAMA Neurology. The transcript for this episode is available for download as an additional file

Episode 5: Penal Code

Qiuwei Yang and Dr. Hugh Silk are joined by family physician Dr. Lisa Gussak to discuss the impact of incarceration on health and medical care. Recorded November 2019. Dr. Gussak\u27s piece Penal Code was first published in Pulse: Voices from the Heart of Medicine. The transcript for this episode is available for download as an additional file

A Smart Switch Configuration and Reliability Assessment Method for Large-Scale Offshore Wind Farm Electrical Collector System

With the development of offshore wind farms (OWFs) in far-offshore and deep-sea areas, each OWF could contain more and more wind turbines and cables, making it imperative to study high-reliability electrical collector system (ECS) for OWF. Enlightened by active distribution network, for OWF, we propose an ECS switch configuration that enables post-fault network recovery, along with a reliability assessment (RA) method based on optimization models. It can also determine the optimal normal state and network reconfiguration strategies to maximize ECS reliability. Case studies on several OWFs demonstrate that the proposed RA method is more computationally efficient and accurate than the traditional sequential Monte-Carlo simulation method. Moreover, the proposed switch configuration, in conjunction with the network reconfiguration strategy and proper topology, provides significant benefits to ECS reliability.Comment: 10 page

Targeting the complex I and III of mitochondrial electron transport chain as a potentially viable option in liver cancer management

Abstract Liver cancer is one of the most common and lethal types of oncological disease in the world, with limited treatment options. New treatment modalities are desperately needed, but their development is hampered by a lack of insight into the underlying molecular mechanisms of disease. It is clear that metabolic reprogramming in mitochondrial function is intimately linked to the liver cancer process, prompting the possibility to explore mitochondrial biochemistry as a potential therapeutic target. Here we report that depletion of mitochondrial DNA, pharmacologic inhibition of mitochondrial electron transport chain (mETC) complex I/complex III, or genetic of mETC complex I restricts cancer cell growth and clonogenicity in various preclinical models of liver cancer, including cell lines, mouse liver organoids, and murine xenografts. The restriction is linked to the production of reactive oxygen species, apoptosis induction and reduced ATP generation. As a result, our findings suggest that the mETC compartment of mitochondria could be a potential therapeutic target in liver cancer