Prognostic value of growth differentiation factor-15 in Chinese patients with heart failure: A prospective observational study

  Background: Growth differentiation factor-15 (GDF-15), a biomarker associated with remodeling, oxidative stress and inflammation, has been used to stratify heart failure (HF) patients. However, its prognostic value in Chinese HF patients is still unknown. Methods: GDF-15 levels were examined on admission in 272 consecutive HF patients in Beijing Hospital (a Chinese tertiary medical center) by a commercial enzyme-linked immunosorbent assay. We recorded the incidence of all-cause mortality and/or readmission for HF during a median follow-up period of 558 days. Patients were stratified according to the tertiles of GDF-15. Results: Fifty-three (19.5%) patients died and 103 (37.9%) patients had major adverse cardiac events (MACE) which included the composite outcome of all-cause mortality or readmission for HF at the end of follow-up. Kaplan-Meier survival curves showed that the third tertile of GDF-15 was associated with increased rate of all-cause mortality (compared with the first and second tertiles, log rank p = 0.001 and 0.001, respectively) or MACE (compared with the first and second tertiles, log rank p = 0.002 and p < 0.001, respectively). In addition, multivariate Cox regression model showed that the highest tertile of GDF-15 was independently associated with increased risk of all-cause death (hazard ratio = 5.95, 95% confidence interval 1.88–18.78, p = 0.002) compared with the lowest tertile after adjustment for related clinical variables such as age, renal function or N-terminal pro-B-type natriuretic peptide.  Conclusions: Plasma GDF-15 is an independent predictor of all-cause mortality in Chinese patients with HF. It may potentially be used to stratify and prognosticate HF patients

Circulating microRNAs as novel biomarkers for dilated cardiomyopathy

Background: Circulating microRNAs (miRNAs) potentially carry disease-specific information. In the current study, we aim to characterize the miRNA signature in plasma from dilated cardiomyopathy (DCM) patients and assess the possible correlation between expression levels of circulating miRNAs and symptom severity in DCM patients. Methods: Using microarray-based miRNA expression profiling, we compared the miRNA expression levels in plasma samples from 4 DCM patients and 3 healthy controls. The expression levels of selected differentially expressed, upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated independently in plasma samples from 19 DCM patients and 20 controls. Results: We observed that plasma miR-3135b (p < 0.001), miR-3908 (p < 0.001) and miR-5571-5p (p < 0.001) were significantly upregulated in DCM patients. The area under receiver operating characteristic (ROC) curves for the 3 miRNAs ranged from 0.83 to 1.00. Moreover, miR-5571-5p levels in plasma were significantly upregulated with severe New York Heart Association (NYHA) classification (p < 0.05). Conclusions: The circulating miRNAs (miR-3135b, miR-3908 and miR-5571-5p) have potential as diagnostic biomarkers for DCM. Additionally, miR-5571-5p correlated with NYHA classification.

Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage

Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases. Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected. Results. Both IMAT and TBS were significantly decreased in patients with NAFLD and early hepatitis. In hepatitis group, they declined prior to changes of liver enzymes. IMAT was significantly higher in cirrhosis Child-Pugh class A group than hepatitis patients and decreased in Child-Pugh class B and class C patients. Both IMAT/albumin and TBS/albumin decreased significantly in hepatitis and NAFLD group patients. Conclusions. This is the first study to discover changes of albumin metal ion and fatty acid binding capacities prior to conventional biomarkers for liver damage in early stage of liver diseases. They may become potential earliest sensitive indicators for liver function evaluation

Identification of urgent gaps in public and policymaker knowledge of heart failure: results of a global survey

Background: Despite advances in the treatment of heart failure (HF) with reduced ejection fraction, people with HF continue to have a high risk of mortality and hospitalisation. Patients also suffer from poor quality of life, with reduced societal and economic participation. The burden of HF on patients and healthcare systems is extraordinary, yet awareness remains low. This survey was conducted to identify gaps in general public and policymaker knowledge around HF. Methods: A closed-question web-based survey of the general public and policymakers was conducted between February and October 2020. Study outcomes assessed the participants’ awareness and understanding of HF symptoms, risk factors and mortality, and views around hospital admissions in their country. Responses were collected using multiple-choice questions. Results: The survey was completed by 26,272 general public respondents in 13 countries and 281 government and public sector policymakers in nine countries. While 99% of general public respondents had heard of HF, their understanding of the condition and its symptoms was poor, and only 6% identified that shortness of breath, fatigue, and leg swelling were the main symptoms of HF. Of policymaker respondents, 14% identified HF as the leading cause of avoidable hospitalisations, and only 4% recognised that ~ 87% of government spending on HF is related to hospitalisations. Conclusions: Major gaps were identified in the understanding of HF and the burden it places on patients and their caregivers, healthcare systems and society. This study confirms an ongoing need for national policy strategies and investment to raise awareness of the importance of HF prevention, early diagnosis, and implementation of effective treatments to reduce hospitalisations and death

Crystal structures and magnetic properties of novel two-dimensional iron tellurides flakes

Since the discovery of intrinsic magnetism in VX2 (X=S, Se and Te), two-dimensional transitional-metal dichalcogenides (2D TMDs), with hexagonal lattices, have become the emerging 2D confined systems showing potential intrinsic magnetic properties at the limit of a few atoms thickness. Often these 2D lattices also form other types of symmetries, like tetragonal or orthorhombic, but they have not been extensively investigated, mainly because of thermodynamic instability during crystal growth. In this study, we showed polymorphically controlled growth of 2D iron-telluride crystals of either hexagonal FeTe2 or tetragonal FeTe by varying the typical growth parameter, the flow rate of hydrogen gas. In addition, we also explored the possibility of the existence of intrinsic magnetism in the two different lattice structures. Furthermore, we demonstrated the different magnetism manifested by the two crystals by means of various characterization techniques.Bachelor of Engineering (Materials Engineering

Circulating microRNAs as novel biomarkers for heart failure

Objective: We Sought to identify circulating miRNAs suitable for HF diagnosis. Methods: In this study, a genome-wide plasma miRNA microarray was performed in 13 HF patients and 3 controls. The expression levels of selected differentially expressed, upregulated miRNAs (miR-3135b, miR-3908 and miR-5571-5p) were validated with quantitative real-time PCR (qRT-PCR) assays in an independent cohort of 33 HF patients and 20 controls. Results: Of all the miRNAs analyzed, miR-3135b (P<0.001), miR-3908 (P<0.001), and miR-5571-5p (P<0.001) were found to have significantly different expression levels in HF compared to controls. The Receiver operating characteristic (ROC) curves for miR-3135b, miR-3908, and miR-5571-5p revealed area under the curve (AUC) values of 1.00, 0.86, and 0.94, respectively. More importantly, miR-3135b and miR-3908 were able to discriminate heart failure with reduced ejection fraction (HFrEF) from heart failure with preserved ejection fraction (HFpEF) (P<0.05). The miR-5571-5p plasma level was significantly associated with NYHA class (P<0.001). Conclusion: This study demonstrated for the first time that some specific microRNAs (miR-3135b, miR-3908, and miR-5571-5p) are useful biomarkers for HF and for differentiating HFrEF from HFpEF. Keywords: miRNAs, heart failure, biomarker

Magnetism of two-dimensional chromium tellurides

2D ferromagnets have garnered considerable attention for their potential applications in spintronics, magnonics, and spin-orbitronics. Chromium tellurides (CrxTey), in particular, have drawn interest due to their exceptional magnetic properties and diverse range of chemical stoichiometries, attributed to the phenomenon of chromium self-intercalation. To provide an in-depth understanding of this complex material class, this review first explains the origin of 2D magnetism using two well-known 2D ferromagnets, CrI3 and Fe3GeTe2, and compares the structures of CrTe2, Cr5Te8, Cr2Te3, and CrTe to clarify the self-intercalation phenomenon. In addition, it summarizes the growth conditions of CrxTey using the chemical vapor deposition approach as well as commonly practiced characterization techniques for 2D ferromagnetism. This review also compares ferromagnetic properties while analyzing how Cr intercalants affect the magnetic. Finally, it suggests that more attention should be focused on this material system to unlock its full practical and academic potential, and proposes directions for future research.Agency for Science, Technology and Research (A*STAR)National Research Foundation (NRF)Published versionZ.L. acknowledges the support from National Research Foundation, Singapore, under its Competitive Research Program (CRP) (NRF-CRP22-2019-0007 and NRF-CRP22-2019-0004), under its NRF-ISF joint research program (NRF2020-NRF-ISF004-3520). This research is also supported by A*STAR under its AME IRG Grant (Project No. A2083c0052)

A simple and general approach for the decoration of interior surfaces of silica hollow microspheres with noble metal nanoparticles and their application in catalysis

Precise control of the size, composition, and assembly process of each component is expected to play a key role in the construction of integrated functional nanostructures. Herein we report a unique sacrificial template method for the fabrication of noble metal@silica hollow microspheres with noble metal (Au, Pt, and Pd) nanoparticles uniformly immobilized on the inner surfaces of silica hollow microspheres. A polystyrene microsphere as a sacrificial template is used to play dual roles, creating a cavity inside the silica microsphere and introducing noble metal nanoparticles into the silica microsphere. Distinct from the reported sacrificial template methods, this method takes advantage of a thermodynamic effect to easily deposit the noble metal nanoparticles with different sizes and compositions onto the template microspheres. In addition, taking Au@silica hollow microspheres for example, they exhibit excellent catalytic activity and recyclability for the reduction of p-nitrophenol (4-NP) by NaBH4

CVD growth of large-scale and highly crystalline 2D chromium telluride nanoflakes

Recently, 2D magnetic materials have attracted much attention due to their potential applications in spintronic devices. Chromium telluride (CrTe) flakes have been reported for hard magnetism with a strong perpendicular anisotropy. However, the synthesis of large-scale CrTe nanoflakes on SiO2/Si substrate is still a challenge. Here, we report the synthesis of large-scale CrTe nanoflakes with a size of up to ∼250 μm on a SiO2/Si substrate via chemical vapor deposition (CVD). Our work demonstrated an effective pathway to synthesize large-scale 2D transition metal tellurides.Agency for Science, Technology and Research (A*STAR)Ministry of Education (MOE)National Research Foundation (NRF)Accepted versionThis work was supported by the National Research Foundation- Competitive Research Program of Singapore NRF-CRP21-2018- 0007 and CRP22-2019-0060, MOE Tier 2 MOE2017-T2-2-136, Tier 3 MOE2018-T3-1-002, and A*Star QTE programme. The National Natural Science Foundation of China (grants 61974120), the Key Program for International Science and Technology Cooperation Project of Shaanxi Province (grants 2018KWZ-08 and 2019KW- 029)