When to Pre-Train Graph Neural Networks? An Answer from Data Generation Perspective!

Recently, graph pre-training has attracted wide research attention, which aims to learn transferable knowledge from unlabeled graph data so as to improve downstream performance. Despite these recent attempts, the negative transfer is a major issue when applying graph pre-trained models to downstream tasks. Existing works made great efforts on the issue of what to pre-train and how to pre-train by designing a number of graph pre-training and fine-tuning strategies. However, there are indeed cases where no matter how advanced the strategy is, the "pre-train and fine-tune" paradigm still cannot achieve clear benefits. This paper introduces a generic framework W2PGNN to answer the crucial question of when to pre-train (i.e., in what situations could we take advantage of graph pre-training) before performing effortful pre-training or fine-tuning. We start from a new perspective to explore the complex generative mechanisms from the pre-training data to downstream data. In particular, W2PGNN first fits the pre-training data into graphon bases, each element of graphon basis (i.e., a graphon) identifies a fundamental transferable pattern shared by a collection of pre-training graphs. All convex combinations of graphon bases give rise to a generator space, from which graphs generated form the solution space for those downstream data that can benefit from pre-training. In this manner, the feasibility of pre-training can be quantified as the generation probability of the downstream data from any generator in the generator space. W2PGNN provides three broad applications, including providing the application scope of graph pre-trained models, quantifying the feasibility of performing pre-training, and helping select pre-training data to enhance downstream performance. We give a theoretically sound solution for the first application and extensive empirical justifications for the latter two applications

Rethinking Event-based Human Pose Estimation with 3D Event Representations

Human pose estimation is a fundamental and appealing task in computer vision. Traditional frame-based cameras and videos are commonly applied, yet, they become less reliable in scenarios under high dynamic range or heavy motion blur. In contrast, event cameras offer a robust solution for navigating these challenging contexts. Predominant methodologies incorporate event cameras into learning frameworks by accumulating events into event frames. However, such methods tend to marginalize the intrinsic asynchronous and high temporal resolution characteristics of events. This disregard leads to a loss in essential temporal dimension data, crucial for discerning distinct actions. To address this issue and to unlock the 3D potential of event information, we introduce two 3D event representations: the Rasterized Event Point Cloud (RasEPC) and the Decoupled Event Voxel (DEV). The RasEPC collates events within concise temporal slices at identical positions, preserving 3D attributes with statistical cues and markedly mitigating memory and computational demands. Meanwhile, the DEV representation discretizes events into voxels and projects them across three orthogonal planes, utilizing decoupled event attention to retrieve 3D cues from the 2D planes. Furthermore, we develop and release EV-3DPW, a synthetic event-based dataset crafted to facilitate training and quantitative analysis in outdoor scenes. On the public real-world DHP19 dataset, our event point cloud technique excels in real-time mobile predictions, while the decoupled event voxel method achieves the highest accuracy. Experiments on EV-3DPW demonstrate that the robustness of our proposed 3D representation methods compared to traditional RGB images and event frame techniques under the same backbones. Our code and dataset have been made publicly available at https://github.com/MasterHow/EventPointPose.Comment: Extended version of arXiv:2206.04511. The code and dataset are available at https://github.com/MasterHow/EventPointPos

Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma

This review systematically examines gender differences in hepatocellular carcinoma (HCC), identifying the influence of sex hormones, genetic variance, and environmental factors on the disease’s epidemiology and treatment outcomes. Recognizing the liver as a sexually dimorphic organ, we highlight how gender-specific risk factors, such as alcohol consumption and obesity, contribute differently to hepatocarcinogenesis in men and women. We explore molecular mechanisms, including the differential expression of androgen and estrogen receptors, which mediate diverse pathways in tumor biology such as cell proliferation, apoptosis, and DNA repair. Our analysis underscores the critical need for gender-specific research in liver cancer, from molecular studies to clinical trials, to improve diagnostic accuracy and therapeutic effectiveness. By incorporating a gender perspective into all facets of liver cancer research, we advocate for a more precise and personalized approach to cancer treatment that acknowledges gender as a significant factor in both the progression of HCC and its response to treatment. This review aims to foster a deeper understanding of the biological and molecular bases of gender differences in HCC and to promote the development of tailored interventions that enhance outcomes for all patients

High-Resolution Boundary Detection for Medical Image Segmentation with Piece-Wise Two-Sample T-Test Augmented Loss

Deep learning methods have contributed substantially to the rapid advancement of medical image segmentation, the quality of which relies on the suitable design of loss functions. Popular loss functions, including the cross-entropy and dice losses, often fall short of boundary detection, thereby limiting high-resolution downstream applications such as automated diagnoses and procedures. We developed a novel loss function that is tailored to reflect the boundary information to enhance the boundary detection. As the contrast between segmentation and background regions along the classification boundary naturally induces heterogeneity over the pixels, we propose the piece-wise two-sample t-test augmented (PTA) loss that is infused with the statistical test for such heterogeneity. We demonstrate the improved boundary detection power of the PTA loss compared to benchmark losses without a t-test component

Circadian rhythms and breast cancer: unraveling the biological clock’s role in tumor microenvironment and ageing

Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved in the pathogenesis of breast cancer. In this paper, we reviewed the molecular mechanisms by which the dysregulation of the circadian genes impacts the development of BC, focusing on the critical clock genes, brain and muscle ARNT-like protein 1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK). We discussed how the circadian rhythm disruption (CRD) changes the tumor microenvironment (TME), immune responses, inflammation, and angiogenesis. The CRD compromises immune surveillance and features and activities of immune effectors, including CD8+ T cells and tumor-associated macrophages, that are important in an effective anti-tumor response. Meanwhile, in this review, we discuss bidirectional interactions: age and circadian rhythms, aging further increases the risk of breast cancer through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, reduced ability to repair damaged DNA, and weakened immunity. These complex interplays open new avenues toward targeted therapies by the combination of clock drugs with chronotherapy to potentiate the immune response while reducing tumor progression for better breast cancer outcomes. This review tries to cover the broad area of emerging knowledge on the tumor-immune nexus affected by the circadian rhythm in breast cancer

The Microstructure and Mechanical Properties of Die-Cast Mg-6Al-2Sm-xCu Alloys

In the present study, the effect of Cu content on the microstructure and mechanical properties of die-cast Mg-6Al-2Sm-xCu (x = 1, 3, 5) alloys has been investigated. The microstructure and components of the alloys were observed and identified by optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive spectroscopy (EDS), respectively. The phases of the alloys were analyzed via X-ray diffractometer (XRD). The mechanical properties at different temperatures were studied by tensile tests. The experimental results show that all die-cast Mg-6Al-2Sm-xCu alloys consist of α-Mg, β-Mg17Al12, Al4Cu9, Al3Sm, and Mg2Cu6Al5 phases. These components, i.e., Al3Sm and Al4Cu9 phases, have high thermal stability and can prohibit dislocation movement and grain boundary sliding. TEM analysis shows that the Al3Sm phase possesses a tetragonal structure. With the increase in Cu content, the microstructure is refined firstly and then becomes coarsened. Moreover, the tensile strength increases firstly and then decreases as Cu content increases at room temperature and an elevated temperature. All fractures of the alloys at room temperature show a complex mode of brittle and ductile fracture. However, at an elevated testing temperature, the fractures of the alloys exhibit more ductile fractures