4,259 research outputs found
Factorization of Standard Model cross sections at ultra high energy
The factorization theorem for organizing multiple electroweak boson emissions
at future colliders with energy far above the electroweak scale is formulated.
Taking the inclusive muon-pair production in electron-positron collisions as an
example, we argue that the summation over isospins is demanded for constructing
the universal distributions of leptons and gauge bosons in an electron. These
parton distributions are shown to have the same infrared structure in the
phases of broken and unbroken electroweak symmetry, an observation consistent
with the Goldstone Equivalence Theorem. The electroweak factorization of
processes involving protons is sketched, with an emphasis on the subtlety of
the scalar distributions.Comment: 5 pages, 3 figure
Sex differences in the progression from cardiac hypertrophy towards heart failure
This thesis aims to investigate differential changes in Ca2+ and Na+ regulation during the development from cardiac hypertrophy to heart failure (HF) between sexes. Clinical evidences show females are more resistant to the development of cardiac hypertrophy and have better survival in HF than males. Oestrogen is postulated to provide cardioprotection although this is still under debate. This work used guinea pigs (GPs), a species with electrophysiology akin to human, that were subjected to aortic constriction (AC) to study the progression from pressure-overload cardiac hypertrophy to HF between sexes. Selected female animals underwent ovariectomy (OVx), mimicking postmenopausal status, to examine the effects of long-term deprivation of ovarian hormones. The effect of oestradiol supplementation was also investigated.
Ventricular myocytes isolated from hearts at cardiac hypertrophy had prolonged action potential duration (APD), increased Ca2+ transient amplitudes and SR Ca2+ content, reduced Na+/K+ ATPase (NKA) function and increased late sodium current (INa,L). Fractional shortening (FS) remained unchanged in these hearts. Compromised FS with detrimental Ca2+ handling, more reduced NKA function and enhanced INa,L were noted at HF. Males showed earlier declined NKA function, more compromised FS and more detrimental Ca2+ handling than females at HF.
Ventricular myocytes from OVx animals showed increased L-type Ca2+ channel current with gating shifts and larger window current, larger Ca2+ transient amplitudes, greater SR Ca2+ content, and increased Ca2+ sparks and waves. OVx myocytes showed more early and delayed afterdepolarisations (EADs and DADs) with DAD-induced extrasystoles following β-adrenergic stimulation. AC with OVx GPs showed more reduced FS, more dysregulated Ca2+ handling, more reduced NKA function and larger INa,L than AC females.
In conclusion, females were more resistant to pressure-overload. Long-term deprivation of ovarian hormones abolishes the slower onset of HF in females, and provides pro-arrhythmic substrates to females. Oestradiol supplementation offered protective effects on OVx GPs.Open Acces
Augmented Reality Emergency System
Fire hazards in a building can be deadly. Knowing what to do is extremely important when a fire occurs in order to survive. However, even with the emergency exit sign, it can still be dangerous to escape recklessly. The goal of this thesis is to find solutions to increase victims\u27 chance of survival during a building fire hazard. This thesis project aims to design an interactive augmented reality system that provides real-time information in fire hazard situations as well as guided escape routes. Specific instructions help to remove the decision-making process from panicked victims who may not be able to think rationally
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