8 research outputs found
Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer
- Author
- A Albini
- A Jemal
- A Moore
- B Gigant
- BJ Howell
- C Adrain
- CM Perou
- E Gilboa
- EL Kaplan
- F Tanaka
- F Tanaka
- G Brattsand
- G Chen
- G Roos
- H Inoue
- H Inoue
- H Sahara
- I Bieche
- I Bieche
- I Bieche
- J Helenius
- J Sakamoto
- K Ichihara
- K Mimori
- K Ogawa
- K Ohta
- K Shimizu
- K Yanaga
- L Wordeman
- M Mori
- M Mori
- MB Terry
- MJ Scanlan
- N Haraguchi
- N Hirokawa
- N Homma
- N Mantel
- N Sadanaga
- P Holmfeldt
- RD Vale
- RF Melhem
- S Aoki
- S Honore
- S Jeha
- SA Endow
- SJ Mistry
- SL Kline-Smith
- ST Brady
- T Fujie
- T Maney
- T Matsumoto
- T Wittmann
- Y Kouzu
- Y Matsumoto
- Y Nakamura
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Mitotic centromere-associated kinesin (MCAK) is a microtubule (MT) depolymerase necessary for ensuring proper kinetochore MT attachment during spindle formation. To determine MCAK expression status and its clinicopathological significance, real-time reverse transcriptase–polymerase chain reaction was used in 65 cases of gastric cancer. MCAK gene expression in cancer tissue was significantly higher than expression in non-malignant tissue (P<0.05). Elevated MCAK expression was significantly associated with lymphatic invasion (P=0.01) and lymph node metastasis (P=0.04). Furthermore, patients with high MCAK expression had a significantly poorer survival rate than those with low MCAK expression (P=0.008). Immunohistochemical study revealed that expression of MCAK was primarily observed in cancer cells. Additionally, a gastric cancer cell line (AZ521) that stably expressed MCAK was established and used to investigate the biological effects of the MCAK gene. In vitro results showed that cells transfected with MCAK had a high rate of proliferation (P<0.001) and increased migratory ability (P<0.001) compared to mock-transfected cells. This study demonstrated that elevated expression of MCAK may be associated with lymphatic invasion, lymph node metastasis, and poor prognosis. These characteristics may be due in part to the increased proliferative and migratory ability of cells expressing MCAK
Mitochondria Are the Target Organelle of Differentiation-Inducing Factor-3, an Anti-Tumor Agent Isolated from Dictyostelium Discoideum
- Author
- A Lena
- BW El Debs
- DR Green
- DR Green
- E Akaishi
- E Gottlieb
- Elad Katz
- F Takahashi-Yanaga
- F Takahashi-Yanaga
- G Kroemer
- G Shaulsky
- H Kikuchi
- H Kikuchi
- H Kikuchi
- H Kikuchi
- H Kuwayama
- Haruhisa Kikuchi
- HR Morris
- HR Morris
- J Wegrzyn
- JS Armstrong
- K Asahi
- K Newell
- K Shimizu
- KJ Newell
- M Kanai
- MC Alley
- N Gokan
- P Djian
- RR Kay
- RR Kay
- S Tanaka
- T Asai
- T Matsuda
- T Sekimoto
- VK Sondak
- Y Kabuyama
- Y Kubohara
- Y Kubohara
- Y Kubohara
- Y Miwa
- Yoshimi Homma
- Yoshiteru Oshima
- Yusuke Matsuo
- Yuzuru Kubohara
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Pathogenicity and field efficacy of the entomopathogenic fungus, Lecanicillium saksenae Kushwaha, Kurihara and Sukarno in the management of rice bug, Leptocorisa acuta Thunberg
- Author
- Assaf A Cerda- Garcia- Rojas C, Torre, MDL.
- Ekesi S Maniania NK.
- Fadayivata S Moravvej G, Karimi J.
- Jasmy Y.
- Jensen MA Losey JE, Hajek AE.
- Kanaoka M Isogai A, Murakoshi S, Ichione M, Suzuki A, Tamura S.
- Kim JJ.
- Kim YH Lee HB, Kim YC, Kim SI.
- Kushwaha RKS.
- Malekan N Hatami B, Ebadi R, Akhava A, Aziz ABA, Radjabi R.
- Mark SG Koike M, Kim JJ, Aiuchi D, Shinya R, Brodeur J.
- Nithya PR Rani ROP.
- Pinto AP Serrano C, Pires T, Mestrinho E, Dias L, Teixeira DM, Caldeira AT.
- Rani ROP Shifa BS, Soni KB, Sudharma K.
- Rani ROP Sudharma K, Nazeema A, Shifa BS.
- Roditakis E Couzin ID, Franks NR, Charnley AK.
- Scorsetti AC Humber RA, Gregorio CD, Lastra CCL.
- Shinde SV Patel KG, Purohit MS, Pandya JR, Sabalpara AN.
- Smitha.
- Sukarno N Kurihara,Y, Ilyas M, Mangunwardoyo W, Yuniarti E, Sjamsuridzal W, Park JY, Saraswati R, Inaba S, Widyastuti Y, Ando K, Harayama S.
- Urquiza AO Keyhani NO.
- Vestergaard S Gillespie AT, Butt TM, Schreiter G, Eilenberg J.
- Yanaga A Shimizu S.
- Publication venue
- 'Informatics Publishing Limited'
- Publication date
- Field of study
The role of GSK3beta in the development of the central nervous system
- Author
- A. Cole
- A. Gärtner
- A. I. Barth
- A. Patapoutian
- A. S. Manoukian
- A. Valerio
- B. P. Vohra
- B.W. Doble
- C. A. Grimes
- C. Gonzalez-Billault
- C. González-Billault
- C. J. Yuskaitis
- C. L. Sayas
- C. Ma
- D. A. Linseman
- D. Baltzis
- E. Beurel
- E.M. Hur
- F. Ille
- F. Takahashi-Yanaga
- F. Zhou
- G. Castelo-Branco
- G. Chen
- G. Chen
- G. N. Bijur
- G. P. Meares
- H. Cui
- H. Jiang
- H. Y. Wang
- J. A. Diehl
- J. A. Hartigan
- J. A. Hartigan
- J. C. Arévalo
- J. Coyle-Rink
- J. Dill
- J. J. Carter
- J. J. Lucas
- J. L. Brewster
- J. Luo
- J. Luo
- J. Malaterre
- J. R. Muñoz-Montaño
- J. R. Woodgett
- K. Leroy
- K. Spittaels
- K. Spittaels
- K. Y. Lee
- L. Ciani
- L. Jin
- L. Lossi
- L. Song
- M. Bianchi
- M. D. Kaytor
- M. H. Maurer
- M. H. Orme
- M. Hetman
- M. Hoshi
- M. Lesort
- M. Pap
- M. Pap
- M. Saito
- M. Takahashi
- M. Takahashi
- M. Tsukane
- M. Yeste-Velasco
- N. Asada
- N. Tong
- N. Trivedi
- P. S. Knoepfler
- P. Watcharasit
- R. G. Goold
- R. G. Goold
- R. J. Crowder
- R. Mishra
- R. Owen
- R. S. Jope
- R. V. Bhat
- S. Boku
- S. Etienne-Manneville
- S. H. Koh
- S. H. Madalosso
- S. K. Hanks
- S. R. D’Mello
- S. Seng
- T. Nedachi
- T. S. Cheng
- T. Shimizu
- T. Takadera
- T. Y. Eom
- T. Yoshimura
- V. Hongisto
- W. Huang
- W. Zhang
- Y. Liu
- Y. Sun
- Z. Ke
- Z. L. Chen
- Z. Sui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
- Author
- A Kode
- A Valencia
- AE Abrahamsson
- AM Coluccia
- BP Tsai
- C Mosimann
- C Niehrs
- CA Thorne
- Catriona H.M. Jamieson
- CC Smith
- EK Siapati
- F Takahashi-Yanaga
- FK Noubissi
- H Clevers
- HK Choi
- I Gehrke
- J Jiang
- J Li
- J Oberoi
- J Rosenbluh
- J Sampietro
- J Skokowa
- J Yeung
- JC Curtin
- JE Bradner
- JM Perry
- JN Anastas
- K Hoffmeyer
- K Petropoulos
- KS Minke
- L Goentoro
- LD Shultz
- N Zhang
- P George
- PP Zarrinkar
- PV Sanchez
- R Balusu
- R Mo
- RG Morgan
- S Ramadoss
- SP Tenbaum
- SW Lane
- T Kajiguchi
- T Kajiguchi
- T Shimizu
- T Tran
- V Perissi
- VS Li
- W Fiskus
- W Fiskus
- W Fiskus
- W Fiskus
- W Li
- Y Wang
- Y Xing
- Y Zhang
- YN Dimitrova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Epigenetic Reprogramming in Cancer
- Author
- A Daser
- A Meissner
- A Tefferi
- A Tefferi
- A Tefferi
- AL Jacobs
- AM Broske
- AM Jankowska
- AM Krais
- AP Feinberg
- BE Bernstein
- BE Bernstein
- C Hartmann
- C Lu
- C Perez
- C Scheel
- CG Lian
- CH Lin
- CX Song
- D Iliopoulos
- D Sturm
- DB Seligson
- DJ Wong
- DT Jones
- DW Parsons
- E Ballestar
- E Lee
- E Li
- E Pronier
- EJ Steine
- ER Mardis
- F Chik
- F Gaudet
- F Mitelman
- F Takahashi-Yanaga
- F Viguie
- G Barreto
- G Haaften van
- G Landan
- GA Challen
- H Easwaran
- H Lin
- H Noushmehr
- H Yan
- H Yang
- HG Linhart
- I Ben-Porath
- I Velichutina
- J Liu
- J Schwartzentruber
- J Score
- J Wang
- J Zuber
- JC Wang
- JF Costello
- JF Costello
- JH Martens
- JJ Briere
- JJ Trowbridge
- JL Hess
- JS Welch
- JU Guo
- JW Riggs
- K Moran-Crusio
- K Rai
- KD Hansen
- KE Szulwach
- KI Ansari
- KI Ansari
- KS Zaret
- L Chen
- L Croce Di
- L Dang
- L Ding
- LA Baker
- LH Schmidt
- M Berdasco
- M Dal Molin
- M Esteller
- M Gehring
- M Kawazu
- M Ko
- M Lechner
- M Okano
- M Sasaki
- M Tahiliani
- M Tan
- MA Dawson
- ME Figueroa
- MF Fraga
- MJ Law
- N Yamaguchi
- NK Cheung
- O Abdel-Wahab
- O Schmalhofer
- OG McDonald
- OH Kramer
- OJ Sansom
- OJ Sansom
- P Chi
- P Liu
- P Wend
- PA Cloos
- PA Jones
- PD Aplan
- PJ Stephens
- PS Knoepfler
- PS Ward
- Q Gao
- R Bonasio
- R Claus
- R Huether
- R Lister
- R Lister
- R Shaknovich
- R Zheng
- RA Gupta
- RA Harris
- RA Irizarry
- RD Morin
- RE Amir
- RK Slotkin
- RM Brena
- RS Hansen
- S Behjati
- S Cortellino
- S Henikoff
- S Ito
- S Ito
- S Kriaucionis
- S Turcan
- SG Jin
- SIS Grewal
- SJ Elsasser
- SM Langemeijer
- T Brabletz
- T Rausch
- T Shimizu
- TJ Ley
- TT Onder
- W Xie
- W Xu
- WA Pastor
- WA Whyte
- X Han
- XJ Yang
- Y Choi
- Y Ionov
- Y Jiao
- Y Shi
- Y Tadokoro
- Y Yamada
- YF He
- Z Gong
- Z Nagy
- ZY Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hexanones
- Author
- A Balsamo
- A Cruz
- A Cruz
- A Finaru
- A Fuerstner
- A Lacassagne
- A Lacassagne
- A Langner
- A McCoubrey
- A Nishinaga
- A Nishinaga
- A Roncaglioni
- A Russell
- A Shibata
- A Sudalai
- A Vandenberghe
- A Wissner
- A Zanardi
- AB Pinkerton
- AB Sen
- AB Sen
- AB Sen
- AB Sen
- AB Sen
- AG Agababyan
- AG Saliner
- AK Nadipuram
- AK Prasad
- ARL Dohme
- BM Tyler
- BN Tripathi
- C Anderson
- C Anderson
- C Clausen
- C Gaina
- C Ji
- C Ling
- C-H Jun
- C-H Jun
- C-H Jun
- C-Z Zhang
- CJ Schyf Van der
- CL Saxe III
- CM Samour
- CM Suter
- CM Suter
- CN Ionescu
- CN Kachru
- CS Neumann
- D Berger
- D Chakravarti
- D Nasipuri
- D Papa
- D Seebach
- D Stepniak-Biniakiewicz
- D Twiss
- DC Hurum
- DD Berge
- DE Aultz
- DJ Collins
- DJ Cram
- DS Mortensen
- E Akaishi
- E Hannig
- E Klarmann
- E Klarmann
- E Klarmann
- E Kubicz
- E Matsuzaki
- E Miller
- E Schrötter
- E Ziegler
- EE Reid
- EH Cox
- EH Cox
- EM Richardson
- F Bigi
- F Bohlmann
- F Ebel
- F Sanchez-Viesca
- F Takahashi-Yanaga
- F Takahashi-Yanaga
- F Unger
- FC Brown
- FD Thomas
- FF Blicke
- FJ Brown
- G Baisch
- G Bartoli
- G Bras Le
- G Illuminati
- G Sandulesco
- GC Misra
- GGS Dutton
- GJ Chen
- GP Mueller
- H Dorn
- H Firouzabadi
- H Haning
- H Ishitani
- H Iwano
- H Kikuchi
- H Kikuchi
- H Kusama
- H Liu
- H Oelschlager
- H Oelschlager
- H Pfanz
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- HJ Saz
- HP Howells
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- 'Springer Science and Business Media LLC'
- Publication date
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JCS/JHRS 2019 guideline on non‐pharmacotherapy of cardiac arrhythmias
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- Abdelrahman M
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- American Board of Internal Medicine
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- Kurosawa H
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- Muser D
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- Nademanee K
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- Soejima K
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- Tsai YC
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- Tsuchihashi K
- Tsuchiya T
- Tsuji A
- Tsujii N
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- Valderrabano M
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- Watanabe H
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- Yamagata K
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- Yamaguchi Y
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- Yamasaki H
- Yamashiro K
- Yamauchi Y
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- Yanaga T
- Yancy CW
- Yang B
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- Yokokawa M
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- Yokoyama K
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- Publication venue
- 'Wiley'
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