Distributed Adaptive Networks: A Graphical Evolutionary Game-Theoretic View

Distributed adaptive filtering has been considered as an effective approach for data processing and estimation over distributed networks. Most existing distributed adaptive filtering algorithms focus on designing different information diffusion rules, regardless of the nature evolutionary characteristic of a distributed network. In this paper, we study the adaptive network from the game theoretic perspective and formulate the distributed adaptive filtering problem as a graphical evolutionary game. With the proposed formulation, the nodes in the network are regarded as players and the local combiner of estimation information from different neighbors is regarded as different strategies selection. We show that this graphical evolutionary game framework is very general and can unify the existing adaptive network algorithms. Based on this framework, as examples, we further propose two error-aware adaptive filtering algorithms. Moreover, we use graphical evolutionary game theory to analyze the information diffusion process over the adaptive networks and evolutionarily stable strategy of the system. Finally, simulation results are shown to verify the effectiveness of our analysis and proposed methods.Comment: Accepted by IEEE Transactions on Signal Processin

Molecular recognition on acoustic wave devices

Microporous thin films composed either of zeolite crystals embedded in sol-gel derived glass or of a molecular coupling layer, zeolite crystals and a porous silica overlayer, were formed on the gold electrodes of Quartz Crystal Microbalances (QCM). The microporosity of the thin films was characterized by in situ nitrogen and vapor sorption isotherms. Both preparation methods result in thin films with substantial microporosity. Selective adsorption based on molecular size exclusion from the microporous films could be achieved

Deep H-band Galaxy Counts and Half-light Radii from HST/NICMOS Parallel Observations

We present deep galaxy counts and half-light radii from F160W ($\lambda_c=1.6\mu$) images obtained with NICMOS on HST. Nearly 9 arcmin$^2$ have been imaged with camera 3, with $3\sigma$ depths ranging from H = 24.3 to 25.5 in a 0.6$''$ diameter aperture. The slope of the counts fainter than H~$= 20$ is 0.31, and the integrated surface density to H$\leq 24.75$ is $4 \times 10^5$ galaxies per square degree. The half-light radii of the galaxies declines steeply with apparent magnitude. At H~$=24$ we are limited by both the delivered FWHM and the detection threshold of the images.Comment: 8 pages. Accepted for publication in ApJ Letter

Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells

<p>Abstract</p> <p>Background</p> <p>Sulfur mustard (SM) is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of SM gas causes airway inflammation and injury. In recent years, there has been increasing evidence of the effectiveness of macrolide antibiotics in treating chronic airway inflammatory diseases. In this study, the anti-cytotoxic and anti-inflammatory effects of a representative macrolide antibiotic, roxithromycin, were tested <it>in vitro </it>using SM-exposed normal human small airway epithelial (SAE) cells and bronchial/tracheal epithelial (BTE) cells. Cell viability, expression of proinflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF), and expression of inducible nitric oxide synthase (iNOS) were examined, since these proinflammatory cytokines/mediators are import indicators of tissue inflammatory responses. We suggest that the influence of roxithromycin on SM-induced inflammatory reaction could play an important therapeutic role in the cytotoxicity exerted by this toxicant.</p> <p>Results</p> <p>MTS assay and Calcein AM/ethidium homodimer (EthD-1) fluorescence staining showed that roxithromycin decreased SM cytotoxicity in both SAE and BTE cells. Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1β, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR. In addition, roxithromycin inhibited the SM-induced overexpression of iNOS, as revealed by immunocytochemical analysis using quantum dots as the fluorophore.</p> <p>Conclusion</p> <p>The present study demonstrates that roxithromycin has inhibitory effects on the cytotoxicity and inflammation provoked by SM in human respiratory epithelial cells. The decreased cytotoxicity in roxithromycin-treated cells likely depends on the ability of the macrolide to down-regulate the production of proinflammatory cytokines and/or mediators. The results obtained in this study suggest that macrolide antibiotics may serve as potential vesicant respiratory therapeutics through mechanisms independent of their antibacterial activity.</p