Rapidly Progressive Pancytopenia, Hepatomegaly, and Abnormal Lung Uptake of Colloid in Systemic Lupus Erythematosus: Possible Saturation of Reticuloendothelial System with Blood Elements

A patient with systemic lupus erythematosus developed severe abdominal pain and tender hepatomegaly associated with progressive pancytopenia and elevated serum levels of circulating immune complexes. Liver scintigram demonstrated extreme hepatomegaly with poor colloid uptake and splenomegaly with increased colloid uptake. An unusual accumulation of colloid in the lungs was also noted. Subsequent clinical and laboratory studies raised the possibility of saturation of the reticuloendothelial system in the liver by circulating immune complexes and blood cells, a condition demonstrated in experimental animals, but not hitherto well documented in the human immune complex disorder

THE STUDY ON APPLICATION OF LATHYROGEN THERAPY TO PROGRESSIVE SYSTEMIC SCLEROSIS

The aim of lathyrogen therapy is, in short, to bring about the disappearance of the cross linkings of the collagen fibers and elastin in the sc1 erotic foci, thus increasing the amount of the soluble component. In the past three years, the author treated 10 cases of progressive systemic sclerosis (PSS) with N-aminoacetonitrile (PCPG-AAN), a newly developed lathyrogen, and obtained satisfactory therapeutic results in the majority of the cases. It seems that PCPG-AAN produces less side effects compared with the other lathyrogens and is effective against not only sclcroden,1a in PSS, but also against the visceral lesions. In addition, it was confirmed that PCPG-AAN can suppress the proliferation of the chick embryo fibroblasts on culture as well as of the mature collagen fibers

D-Penicillamine-Induced Polymyositis Occurring in Patients with Rheumatoid Arthritis: A Report of Two Cases and Demonstration of a Positive Lymphocyte Stimulation Test to D-Penicillamine

Two patients with erosive, seropositive rheumatoid arthritis developed polymyositis during treatment with D-penicillamine. In both patients the HLA tissue typing revealed the presence of DR4. The myopathy improved promptly after withdrawal of D-penicillamine and institution of prednisolone therapy. In one patient, hypersensitivity to D-penicillamine was demonstrated by a lymphocyte stimulation test. This is the first case of D-penicillamine-induced polymyositis in which T-cell proliferative response to D-penicillamine was demonstrated in vitro

国の累積債務１０００兆円時代における税教育理論の構築とカリキュラム開発

application/pdfシチズンシップ発足前のイギリスの第９学年の生徒と税に関する学習を終了した中学３年生に対する税の知識と意識についての調査結果の比較により，税についての教育を受けた生徒の方が，政府からの財やサービスの享受と納税額のバランスの必要性についてよく理解していることが示された。　財政規模についての考え方は国によって異なり，学校における税についての教育内容も異なる。日本は世界的に見ると中程度の福祉であるのに税は低負担であることが国の累積債務が巨額になっている根本的な理由であるが，中程度の福祉を実現するための税教育になっていない。この研究で中程度の福祉を持続可能にするための税教育カリキュラムを提案した。We found that the students who learned governmental finance and tax understood more the need for the balance between governmental services and tax revenue than the students who didn't learn them by the comparative researching of English students and Japanese 9th grade students. The idea of the size of governmental finance is different from country to country and the tax education in school is different from country to country. The basic reason of the Japanese gigantic governmental deficit is imbalance between the size of governmental services and tax revenue. The content of tax education in school in Japan is not suitable to the middle welfare state. This research study presented the new curriculum for tax education in the middle school.2011年度～2013年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書2365329