視床の過活動と治療抵抗性うつ病及びうつ病の不良な治療反応性との関連 : 安静時fMRI 研究

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

Review of clinical psychological studies on transference during psychotherapy

The purpose of this study was to review the evidence-based clinical psychological studies on transference during psychotherapy. A PsychINFO search identified 17 studies fitting our criterion. These studies could be classified into three categories: studies based on structured or semi-structured interviews, client and therapist ratings, and outside experts ratings. The studies used four rating methods. These studies investigated the therapists' impasses, correlation between transference and outcome, relationship factors (attachment, empathy, real-relationship, and working alliance), and the pattern of transference. Moreover, there was only one evidence-based study conducted in Japan

Infrared Properties of SiO Maser Sources in Late-Type Stars

Results of an SiO maser survey for the late-type stars selected by the IRTS (Infrared Telescope in Space) are presented. We have detected SiO J=1-0, v=1 and/or v=2 lines in 27 stars out of 59 stars. The maser intensity increases with the depth of the H2O absorption in the infrared spectra and redness of the 2.2 and 12 micron color. The column densities of the water vapor in the target stars are estimated from the depth of the water absorption in the IRTS spectra. We found that the SiO maser was detected mostly in the stars with the column density of water vapor higher than 3x10^19-3x10^20 cm^-2. We further estimate the density of hydrogen molecules in the outer atmosphere corresponding to these column densities, obtaining 10^9 - 10^10 cm^-3 as a lower limit. These values are roughly in agreement with the critical hydrogen density predicted by models for the excitation of the SiO masers. It is possible that the SiO masers are excited in clumps with even higher than this density. The present results provide useful information on the understanding of the physical conditions of the outer atmospheres in late-type stars.Comment: 26 pages with 6 figures, accepted for PAS

Effects of behavioural activation on the neural circuit related to intrinsic motivation

[Background] Behavioural activation is an efficient treatment for depression and can improve intrinsic motivation. Previous studies have revealed that the frontostriatal circuit is involved in intrinsic motivation; however, there are no data on how behavioural activation affects the frontostriatal circuit. [Aims] We aimed to investigate behavioural activation-related changes in the frontostriatal circuit. [Method] Fifty-nine individuals with subthreshold depression were randomly assigned to either the intervention or non-intervention group. The intervention group received five weekly behavioural activation sessions. The participants underwent functional magnetic resonance imaging scanning on two separate occasions while performing a stopwatch task based on intrinsic motivation. We investigated changes in neural activity and functional connectivity after behavioural activation. [Results] After behavioural activation, the intervention group had increased activation and connectivity in the frontostriatal region compared with the non-intervention group. The increased activation in the right middle frontal gyrus was correlated with an improvement of subjective sensitivity to environmental rewards. [Conclusions] Behavioural activation-related changes to the frontostriatal circuit advance our understanding of psychotherapy-induced improvements in the neural basis of intrinsic motivation. [Declaration of interest] None.This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from Japan Society for the Promotion of Science, JSPS (grants 16H06395 and 16H06399), and grant 23118004 from the Ministry of Education, Culture, Sports, Science and Technology, Japan. This work was partially supported by the programme for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) by Japan Agency for Medical Research and Development, AMED (grant 15dm0207012h0002) and Integrated Research on Depression, Dementia and Development Disorders by AMED (grant 16dm0107093h0001). The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation or review of the manuscript or decision to submit the manuscript for publication

A Review of Studies on Self-help Group for Cancer Survivors

The purpose of this study was to review the previous studies to examine the evidence for self-help groups for cancer survivors. The search strategy began with 5 electronic databases such as PsycARTICLES (2000-2011), CancerLit (2000-2011), PubMed (2000-2011), PsycINFO (2000-2011), and CiNii (Citation Information by NII, 2000-2011). A total of 27 scientific literatures were included with no psychological research, in which most were nursing researches. The authors discussed three issues: the method of the research, the difference between support group and self-help group, and the evidence of the self-help group, and then stressed the importance of researches using quantitative methods and researches conducted by the survivors themselves

Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study

Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year. Patients and methods: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2, 494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II). We conducted a cohort study of three groups (low-, middle-, and high-symptom groups) divided based on BDI-II scores, over a 1 year period with the use of bimonthly assessments. Temporal changes of depressive symptoms were analyzed using linear mixed modeling and growth mixture modeling. Results: First, we found that late adolescents with subthreshold depression (high depressive symptoms) were split between the increasing and decreasing depressive symptoms groups, whereas the majority of the less-symptoms group remained stable during 1 year. Second, in comparison with late adolescents with less depressive symptoms, those with subthreshold depression had an elevated risk of later depression. Conclusion: Some late adolescents with subthreshold depression had increased depressive symptoms and developed an MDE during 1 year. Therefore, it is necessary for us to rigorously assess the changes in subthreshold depressive symptoms over time in late adolescents

Enduring effects of a 5-week behavioral activation program for subthreshold depression among late adolescents: an exploratory randomized controlled trial

Background: No significant effect of psychological treatment has been reported from meta-analysis of subthreshold depression patients and control subjects at 1-year follow-up. However, behavioral activation is a simpler and more cost-effective treatment than cognitive behavioral therapy. The primary purpose of this study was to assess by comparison to an assessment-only control group whether the effects of behavioral activation program for depressive symptoms can persist up to 1-year follow-up without the use of antidepressants or other psychotherapy. Patients and methods: Late adolescent students were the population targeted in this study. Participants were allocated randomly to an intervention group (n=62) or a control group (n=56). Treatment consisted of five-weekly 60-minute sessions. Participants underwent a structured interview and completed self-report scales at 1 year post-assessment. Results: Late adolescent students receiving treatment had significantly lower mean Beck Depression Inventory, second edition scores at 1-year follow-up than control group students. The effect size (Hedges’ g) for between-group differences at 1-year follow-up was -0.41. Conclusion: Our behavioral activation program is simple and short. Nevertheless, the results obtained at 1-year follow-up of the control group and late adolescent students receiving treatment indicated a significant difference in their Beck Depression Inventory, second edition scores. Our 5-week behavioral activation program based on behavioral characteristics for subthreshold depression might be promising for subthreshold depression. The sample examined for this study imposed some study limitations