FUNDAMENTAL EXPERIMENT FOR CONSTRUCTING IT-TOW

The purpose of this study was to collect some baseline data which may be used for developing an IT-tow system by using a load cell. The pulling forces were measured in 3 tests, hold1 phase, hold2 phase, and drive phase. The pulling force decreased in drive phase defined as the phase the pullers are driven by opponent. This is because the pulling force in this study was defined as tension of the rope, and then pulling force measured in this phase is not produced by subject but produced by examiners side. If the IT-TOW is made by using the load cell, 2 machines have to exchange and reproduce the pulling force of each other. In case the load cell received 2 different pulling forces, pulling force produced by one side may not be measured with accuracy. To put IT-TOW into practice, the pulling force data must be exchanged and not be measured by a load cell, but defined by another system

BACKWARD PULLING DISTANCE IN DROP PHASE FOR JAPANESE ELITE FEMALE TUG-OF-WAR ATHLETES

The purpose of this study was to clarify the backward pulling distance on 1 second of drop phase for Japanese female elite tug of war team. In order to examine the pulling movement, digital video camera was set at the ceiling of gymnasium, the game performed by 5 elite teams (finalists) and 5 normal teams (non finalists) in 2006 All Japan Tug of War Championship tournament were videotaped from right above and analyzed by using two-dimensional motion analysis system. Backward pulling distance was measured and compared between groups. In some pullers, elite team pulled the rope longer significantly. This might be caused by difference of individual or team pulling techniques to synchronize timing and direction

Nonlinear electrical impedance spectroscopy of viruses using very high electric fields created by nanogap electrodes

Our living sphere is constantly exposed to a wide range of pathogenic viruses, which can be either known, or of novel origin. Currently, there is no methodology for continuously monitoring the environment for viruses in general, much less a methodology that allows the rapid and sensitive identification of a wide variety of viruses responsible for communicable diseases. Traditional approaches, based on PCR and immunodetection systems, only detect known or specifically targeted viruses. We here describe a simple device that can potentially detect any virus between nanogap electrodes using nonlinear impedance spectroscopy. Three test viruses, differing in shape and size, were used to demonstrate the general applicability of this approach: baculovirus，tobacco mosaic virus, and influenza virus. We show that each of the virus types responded differently in the nanogap to changes in the electric field strength, and the impedance of the virus solutions differed depending both on virus type and virus concentration. These preliminary results show that the three virus types can be distinguished and their approximate concentrations determined. Although further studies are required, the proposed nonlinear impedance spectroscopy method may achieve a sensitivity comparable to that of more traditional, but less versatile, virus detection systems

Critical behavior and magnetocaloric effect in Tsai-type 2/1 and 1/1 quasicrystal approximants

Stable Tsai-type quinary 1/1 and 2/1 approximant crystals (ACs) with chemical compositions Au56.25Al10Cu7In13Tb13.75 and Au55.5Al10Cu7In13Tb14.5, respectively, exhibiting ferromagnetic (FM) long-range orders were successfully synthesized and studied for their magnetic properties and magnetocaloric effect. The 1/1 and 2/1 ACs primarily differ in their long-range atomic arrangement and rare earth (RE) distribution, with the latter approaching quasiperiodic order while still preserving periodicity. Analyses based on the scaling principle and Kouvel-Fisher (KF) relations suggested mean-field-like behavior near Curie temperatures in both compounds. From magnetization measurements and the Maxwell equation, a magnetic entropy change of -4.3 and -4.1 J/K mol Tb were derived under a magnetic field change of 7 T for the 1/1 and 2/1 ACs, respectively. The results indicated a prominent role of intra-cluster magnetic interactions on critical behavior and magnetic entropy of the Tsai-type compounds

前立腺がん細胞株の去勢抵抗性獲得メカニズムに関する研究

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 児玉 龍彦, 東京大学教授 油谷 浩幸, 東京大学教授 深山 正久, 東京大学准教授 久米 春喜, 東京大学特任教授 田中 十志也, 東京大学特任准教授 穴井 元暢University of Tokyo(東京大学

Longevity-associated NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Daily Alcohol Drinking on Yearly Changes in Serum Total and LDL Cholesterol in Japanese Men

Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p0.036 and p0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.</p