Associations between Comorbidities and Acute Exacerbation of Interstitial Lung Disease after Primary Lung Cancer Surgery

Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD

LODE : A Legal Ontology DevelopmentEnvironment Using Natural Language and Case Ontologies

this paper focuses on a construction of a domain ontology,i

Genetic and environmental etiology of stability and changes in self-esteem linked to personality: A Japanese twin study

This study used a behavioral genetic approach to examine the genetic and environmental etiology of stability and changes in self-esteem in relation to personality. Multiple genetic analyses were conducted on a longitudinal dataset of self-esteem and Big Five personality scores among young adult Japanese twins over the course of a decade. There were 1221 individuals for whom data were available on both self-esteem and the Big Five personality test at Time 1 and 365 at Time 2. The mean interval between the two times was 9.95 years. Genetic effects on self-esteem were robust, and the same genes were responsible for the stability of self-esteem in individuals over time. Nearly half of the variance in self-esteem was explained by a new genetic factor arising during the decade, suggesting that genetic innovation of self-esteem occurred in early adult life. The genetic and environmental covariance structure between personality and self-esteem in individuals was constant over a decade, providing evidence that the stability of self-esteem was largely attributable to personality. However, genetics for self-esteem independent of personality still contributed to stability over time, differentiating the concept of self-esteem from personality as a trait in terms of its genetic and environmental etiological levels