2 research outputs found
Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates glomerular fibrin deposition in a rat model of acute renal failure
High Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is
the third-leading cause of cancer-related death. Owing to
its poor prognosis, new molecular biomarkers for PDAC
are needed. Annexin A10 (ANXA10) is a calcium-
/phospholipid-binding protein belonging to the annexin
family of proteins. ANXA10 is not only associated with
gastric phenotypes, but also acts an independent
prognostic factor in several cancers. However, the role
of ANXA10 in PDAC remains unknown. Therefore, we
examined the relationship between ANXA10 and the
prognosis of PDAC. We analyzed the expression of
ANXA10 using data from public databases, and
performed immunohistochemistry analysis for 81 PDAC
cases. We then investigated the relationship between
ANXA10 expression and clinicopathological features.
ANXA10 was detected in 47 of 81 PDAC cases (58%).
High expression of ANXA10 was significantly related to
poor overall survival (OS; p=0.011). Univariate analysis
of OS revealed three prognostic parameters: tumor grade
(p=0.046), perineural invasion (p=0.017), and ANXA10
expression (p=0.012). Multivariate analysis indicated
that ANXA10 expression (p<0.01) alone was a
prognostic factor in PDAC cases. Our findings suggest
that ANXA10 expression is an independent prognostic
factor in PDAC cases and shows promise as a new
biomarker in PDAC