Characterization of Vanadium and Sulfur Containing Compounds of Kazakhstan Petroleum Vacuum Residuum

In the paper, bulk property and chemical composition of Kazakhstan vacuum residuum were characterized. Sulfides and thiophenes were selectively isolated from the residuum and characterized by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Molecular weights of the sulfur compounds were varied from 150 to 800 Da and S1 , S2 , O1S1 , O2S1 , N1S1 class species were assigned in the heavy oil derived methylsulfonium. Vanadyl porphyrins characterized by positive-ion electrospray ionization and FT-ICR MS, which showed that etioporphyrins (ETIO) (CnH2n-28N4V1O1 , corresponding to DBE = 17) and deoxophylloerythroetioporphyrins (DPEP) (CnH2n-30N4V1O1, corresponding to DBE = 18). It should be noted that the vanadyl porphyrins were most abundant

Does sacubitril/valsartan work in children with heart failure?—a pilot study

BackgroundSacubitril/valsartan is an angiotensin receptor neprilysin antagonist (ARNI) approved for adult heart failure (HF). Its safety and efficacy in pediatric HF patients with cardiomyopathy or congenital heart disease are poorly understood. A pilot study was conducted to assess the clinical response, efficacy and safety of sacubitril/valsartan in this population at a tertiary care hospital in China.MethodsClinical parameters of patients who received sacubitril/valsartan from January 2019 to March 2023 were retrospectively collected and analyzed. Children over 1 month with a left ventricular ejection fraction (LVEF) <45% were included. Clinical efficacy was evaluated by echocardiographic LVEF, N-terminal pro-brain natriuretic peptide (NT-proBNP), New York Heart Association (NYHA) HF classification, HF re-admission, and death or transplantation. The initial dose was either 0.2 mg/kg bid or 0.4 mg/kg bid, with a target dose of 2.3 mg/kg bid or 3.1 mg/kg bid.ResultsForty-five patients (60% male) with a median age of 7.86 years were enrolled. Among them, 23 had congenital heart disease and 22 had cardiomyopathies. The median maintenance dose was 0.76 mg/kg. The primary endpoint of LVEF up to 45% was reached by 24 patients (53.3%). The median NT-proBNP was significantly decreased from 5,501.5 pg/ml to 2,241.5 pg/ml (P < 0.001), more in congenital heart disease than in cardiomyopathies (P = 0.032). The NYHA HF class was improved or remained stable in 42 cases (93.3%). During a median follow-up of 1.23 years, 13 patients (28.9%) were re-hospitalized due to HF, and 9 patients (20%) died or underwent transplantation. Hypotension was the main adverse event, occurring in 8 patients.ConclusionsSacubitril/valsartan may be effective in children with HF, but its safety and outcomes may differ depending on the etiology and anatomy of HF. Early post-operative congenital heart disease patients had less tolerance, more hypotension but better recovery and outcomes, while mid- and late- post-operative congenital heart disease patients and cardiomyopathy patients had less side effects but poorer clinical outcomes

Elimination of the Ion–Molecule Association in Electrospray High-Resolution Mass Spectrometry Analyses for Petroleum Fractions

Electrospray ionization (ESI) coupled with high-resolution mass spectrometry (HRMS) is rapidly developing into a powerful tool for the molecular characterization of petroleum fractions. However, the occurrence of ion–molecule aggregates seriously affects the interpretation of the mass spectrometry results. Ion–molecule aggregates are not inherent compounds in petroleum but they are produced during the analysis of petroleum samples by high-resolution mass spectrometry. Also, the classes of aggregates are the same as many compounds in petroleum. Therefore, the removal of these species is crucial, and their analysis from methods of dissociation and mechanism points of view is essential for this purpose. In this study, aggregates of a vacuum gas oil fraction were analyzed and the types were defined. The compositions of the aggregates were characterized by changing operating conditions. Several factors affecting the aggregates were evaluated by a parameter of dissociation efficiency. By establishing the operating methods, the residual content of the aggregates can be controlled by less than 1% of the total ions. The results are instructive for the molecular characterization of petroleum fractions by using mass spectrometry with ESI ionization

A Study on Stress Coping Strategies of Doctors in the COVID-19 Pandemic: Considering Impact of Internet Hospital

Since the outbreak of COVID-19 in Wuhan, the booming development of Internet hospital has changed doctors’ job environment. With the new pandemic outbreaking in Hebei, how doctors choose correct coping strategies has been in the limelight. Based on the information processing theory and the job demands-resources model (JD-R), this paper explores the mechanism of doctors’ stress coping under the epidemic. We obtain highquality data by cooperating with the largest authoritative doctor training platform in China. The expected result is that popularity of Internet hospital will inhibit frontline but promote non-frontline doctors to solve problems. Additionally, the challenging environment no longer promotes the conversion of job resources into engagement but makes doctors choose more emotion-focused coping. This paper extends the JD-R from information perspective and guides the government to manage doctors more reasonably during pandemics

Research Progress on Rapid Detection Technology and Standardized Application of Foodborne Pathogens

In recent years, with the rapid development of new food safety testing technologies, rapid detection of foodborne pathogens has improved traditional detection methods that suffer from long cycles and low sensitivity, thus playing an important role in safeguarding public health and promoting economic and social development. Standardization is the key to the promotion and application of rapid detection technologies. This article systematically introduces commonly used rapid detection methods for foodborne pathogens, including physiological and biochemical detection, immunological detection, and molecular detection. The principles, research progress, advantages, and disadvantages of various methods are summarized. What’s more, domestic and abroad standardization status and application of rapid detection technologies are further introduced from a standardization perspective. The new rapid detection technology has the advantages of sensitivity, speed, and strong specificity, but there are also certain shortcomings, such as the cumbersome pre-treatment of antibodies in immune detection technology, the confusion of contaminated bacteria in physiological and biochemical detection technology, and certain false positives in molecular detection technology. In addition, most detection methods are still illegal and lack unified judgment standards. The relevant standard systems at home and abroad are still incomplete, which restricts the standardized promotion and application of rapid detection technology. Therefore, this article proposes suggestions for the future development of rapid detection technology for foodborne pathogens from the perspective of standardization, in order to provide reference for the research and standardization construction of food safety-related technologies in the future

Aggregation of petroporphyrins and fragmentation of porphyrin ions: Characterized by TIMS-TOF MS and FT-ICR MS

International audienceVanadyl porphyrins in the heavy crude oil were enriched and characterized by trapped ion mobility spectrometry-time of flight mass spectrometry (TIMS-TOF MS) and Fourier transform ion cyclotron resonance mass spectrometry. Two series of mobiligram peaks were present in the extracted ion mobility spectra of the petroporphyrins. Collision induced dissociation (CID) revealed that one peak series was [M + H]+, while the other peak series was cluster ions, which may contain an amine in the ions. Model compounds were used to investigate the aggregation and fragmentation behavior of porphyrin ions. It was found that all the porphyrins tend to form adduct ions in the electrospray ionization, such as [2 M]+, [2 M + H]+, [2 M + Na]+ and cluster ions of porphyrin with other compounds. This implies the strong molecular aggregation potential of porphyrins with themselves and other petroleum molecules. The porphyrin cluster ions generated in ionization source could decompose and continuously disaggregate during the transmission in the MS. The [M]+ and [M + H]+ were dissociated into fragment ions and the cluster ions were disaggregated into [M]+ and [M + H]+ simultaneously with high collision energy. The CID analysis of Zn-OEP porphyrin showed that [M + H]+ has a lower dissociation energy than [M]+. The results provide instructive information for the understanding of aggregation and fragmentation behavior of petroporphyrins as well petroleum asphaltenes