Formulation and Evaluation of Silver Nanoparticles of Methanolic extract of Solanum virginianum L. for Antimicrobial and Antioxidant potential

Nanotechnology can be termed as the characterization, Fabrication, exploration and application of nano sized materials where nano denotes extremely minute structures ranging 1-100 nm. Among the new towards for employ nanotechnology success in medicine, various nano particulates offer some special advantages as pharmaceutical delivery systems and image advancement agents Solanum virginianum L, (wild eggplant or nightshade plant), are a prickly herb, belongs to family Solanaceae. It has spines throughout the plant. Various phytoconstituents have been found, the major constituents is alkaloid. It has vital role in various traditional as well as medicinal uses for curing internal and external physiological disorders. This plant has also used for phytoremediation as it possess the ability to degrade carbofuran residues in rice field soil and therefore the plant species may further be investigated for its phytoremidial role. In the present study, AgNPs of plant Solanum virginianum was synthesized and characterized by UV-Vis spectrophotometer, FT-IR and SEM analysis. In-vitro anti-oxidant and anti-microbial investigations showed the impressive results. However the present investigation adverts that the AgNPs can be used to prepare and develop Nano-drug, new generation of antimicrobials, drug delivery systems, biosensors and different other applications such as Ag based dressing, Ag-coated medicinal device Keywords: Silver nanoparticles, Solanum virginianum l, anti-microbial, antioxidants, antifunga

Ensuring safety and efficacy in combination products: regulatory challenges and best practices

Combination products, amalgamating drugs, biologics, and medical devices, have revolutionized the healthcare landscape with their potential for innovative therapies. However, the intersection of diverse components within these products presents a complex regulatory environment, demanding rigorous attention to safety and efficacy. This article delves into the intricate landscape of regulatory considerations, safety, and efficacy assessments pertaining to combination products—a category at the intersection of drugs, devices, and biologics. The regulatory framework, primarily governed by the U.S. Food and Drug Administration (FDA), necessitates a nuanced classification determining the regulatory pathway. Collaboration between diverse regulatory centers, such as the Center for Drug Evaluation and Research (CDER) and the Center for Devices and Radiological Health (CDRH), underscores the integrated approach required for these innovative healthcare solutions. Safety considerations unravel the potential risks and adverse events associated with combining diverse components, emphasizing the need for robust risk assessment and mitigation strategies. The evaluation of efficacy involves sophisticated methodologies, clinical trials, and post-market surveillance, with recent advancements incorporating digital technologies. This comprehensive exploration aims to contribute to the evolving understanding and best practices in the regulatory and scientific realms, fostering collaboration and innovation in the development and assessment of combination products

High-spin spectroscopy in 207^{207}At: Evidence of a 29/2+^{+} isomeric state

Yrast and near-yrast states above the known 25/2$^{+}$ isomer in $^{207}$At are established for the first time. The level scheme is extended up to 47/2$\hbar$ and 6.5 MeV with the addition of about 60 new $\gamma$-ray transitions. The half-life of the 25/2$^{+}$ isomer is revisited and a value of $T_{1/2}$ = 107.5(9) ns is deduced. Evidence of a hitherto unobserved 29/2$^{+}$ isomer in $^{207}$At is presented. A systematic study of $B(E3)$ values for the transitions de-exciting the 29/2$^{+}$ isomer in the neighboring odd-$A$ At isotopes suggests a half-life in the 2$-$4 $\mu$s range for this state in $^{207}$At. The experimental results are compared with large-scale shell-model calculations performed using the KHM3Y effective interaction in the $Z$ = 50$-$126, $N$ = 82$-$184 model space and an overall good agreement is noted between the theory and the experiment. A qualitative comparison of the excited states and the isomers with analogous states in neighboring nuclei provides further insight into the structure of $^{207}$At.Comment: 15 pages, 13 figure

Coexisting single-particle excitations and octupole correlations in transitional nucleus 217Ra\mathbf{^{217}Ra}

The level structure of the transitional nucleus $\mathrm{^{217}Ra}$ has been extended with the addition of around 20 new transitions. The discrepancies between the placements of several transitions reported in the earlier studies are resolved. The newly-established negative-parity sequence at low excitation energies hints at the expected parity-doublet structures in this nucleus. The properties of the observed simplex bands are compared with that of similar bands in neighboring nuclei. Since the presence of parity-doublet structures reflect octupole correlations, theoretical calculations using reflection-asymmetric triaxial particle rotor model (RAT-PRM) have been performed. A comparison of the observed features of the simplex bands with the predictions of the RAT-PRM calculations suggests that $\mathrm{^{217}Ra}$ exhibits an intermediate the behavior between the extremes of spherical and octupole-deformed nuclei. The termination of the simplex bands at intermediate energies and the structures lying above reflect the dominance of the single-particle excitations at higher excitation energies.Comment: 15 pages, 16 figure

DMBA induced mammary tumor study of Phyto-fabricated sliver nanoparticles from Russelia Equisetiformis flower extract in rat

The mammary tumor is the world's most frequent ailment, and it is substantially more common in women. There are several forms of treatment and care available in the globe for tumors, the most common of which being chemotherapy, radiation therapy, and surgery with lots of harmful responses. Cancer has been treated since ancient times by herbs with various herbs and metals. synthesized AgNPs-REEE were characterized by Analytical methods such as dynamic light scattering (DLS), Zeta potential, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX) and Dynamic Light Scattering (DLS).All of the animals in this study had tumors caused by DMBA Apart from the vehicle control group, and they were divided into different groups such as only DMBA(7,12-dimethylbenz[a]anthracene) induced group, treatment group of ethanolic extract of Russelia equisetiformis (REEE) flower and sliver nanoparticles of ethanolic extract of Russelia equisetiformis (REEE) flower and sliver nanoparticles of ethanolic extract (AgNPs -REEE).the dose were decide by acute toxicity study. After compaction treatment time all animal were sacrifices and evaluate parameter like tumor weight, Tumor volume, biochemical parameter, hormonal assay and histopathology of breast tumor. It is observed that the size distribution of AgNPs ranges from 50 to 950 nm.&nbsp