Dark sector interaction: a remedy of the tensions between CMB and LSS data

The well-known tensions on the cosmological parameters $H_0$ and $\sigma_8$ within the $\Lambda$CDM cosmology shown by the Planck-CMB and LSS data are possibly due to the systematics in the data or our ignorance of some new physics beyond the $\Lambda$CDM model. In this letter, we focus on the second possibility, and investigate a minimal extension of the $\Lambda$CDM model by allowing a coupling between its dark sector components (dark energy and dark matter). We analyze this scenario with Planck-CMB, KiDS and HST data, and find that the $H_0$ and $\sigma_8$ tensions disappear at 68\% CL. In the joint analyzes with Planck, HST and KiDS data, we find non-zero coupling in the dark sector up to 99\% CL. Thus, we find a strong statistical support from the observational data for an interaction in the dark sector of the Universe while solving the $H_0$ and $\sigma_8$ tensions simultaneously.Comment: 5 pages, 3 figure

Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction. In the studied work, we performed molecular docking of CPT derivatives against Topo-I and developed the quantitative structure activity relationship (QSAR) model for anticancer activity screening. For QSAR, we used CPT and other anticancer drugs with its IC50 values. We used a total of forty seven anticancer drugs as training set and eight compounds as test set and thirty derivatives of CPT as query set. Total of fifty two chemical descriptors were used for the quantitative data calculation. Only four showed good correlation with the experimental activity. Forward feed regression method was used for development of multiple linear regression (MLR) QSAR model. Model showed acceptable regression coefficient (r2) 0.89 (i.e., 89% of correlation) and cross validation coefficient (rCV2) 0.86 (i.e., 86 % of prediction accuracy). After drug likeness test, ten compounds namely, MSB3a, MSB3b, MSB19, MSB22L, MSB22M, MSB22O, MSB22R, MSB25D, MSB37G and MSB39D, showed promising predicted anticancer activity and drug likeness properties. Out of ten, only six compounds namely, MSB19, MSB22L, MSBM, MSB22O, MSB22R and MSB37D indicate two times more activity than the parent CPT compound. In molecular docking studies, all the identified active CPT derivatives showed high binding affinity with Topo-I. QSAR study indicates that connectivity index, electron affinity, mol.wt. & ether group count highly contribute to inhibitory activity of CPT derivatives. These results can offer useful references for directing the molecular design of Topo-I inhibitor with improved anticancer activity.
&#xa

Observational Constraints on generalized dark matter properties in the presence of neutrinos with final Plank release

In this paper, we investigate an extension of standard $\Lambda$CDM model by allowing: a temporal evolution in the equation of state (EoS) of DM via Chevallier-Polarski-Linder parametrization, and the constant non-null sound speed. We also consider the properties of neutrinos, such as the effective neutrino mass and the effective number of neutrino species as free parameters. We derive the constraints on this scenario by using the data from the Planck-2018 cosmic microwave background (CMB), baryonic acoustic oscillations (BAO), the local value of the Hubble constant from the Hubble Space Telescope (HST), and some large scale structure (LSS) information from the abundance of galaxy clusters. We find constraints on the EoS and sound speed of DM very close to the null value in all cases thus no significant evidence can be stated beyond the standard CDM paradigm, and we conclude that the present observational data favor DM as a pressureless fluid. In all cases, we find the tighter upper bounds on the sum of neutrino masses. The most tight upper bound is $\sum m_\nu < 0.17$ eV at 95\% CL, imposed with the addition of HST prior in the analysis. We also observe the effects of neutrino properties on the extended DM parameters and also on other parameters. We find significantly lower mean values of $\sigma_8$ in all cases which are in agreement with the LSS measurements. Thus, the well-known $\sigma_8$ tension is reconciled in the considered model.Comment: 10 pages, 4 Figure panels. arXiv admin note: text overlap with arXiv:1901.0754

New Measure Routing Algorithm for PEGASIS Wireless Sensor Network

The sensor node spends the maximum energy in data transmission for maintaining this issue we proposed a new routing protocol for sensor nodes in WSN. A sensor network is organized into many sets and all sets collect the data with minimum edge weight in a parallel way so doing this all sets create a minimum edge weight chain. Further, the sets make a head node that is near the base station. All sets have a unique chain in this round after that all set again to select a head node on the basis of high residual energy, less mobility, and minimum distance to the base station that the head node sends the data to the base station. Further, our proposed routing algorithms save energy. We simulated the proposed model in MATLAB all simulation result is better than both routing algorithms

Effect of Proximity and Aperture Coupling on Multiband Operation of Corner Truncated Microstrip Antenna

The effect of proximity and aperture coupling on the resonance behavior of the corner truncated microstrip antenna is presented. With proximity coupling and H-slot in the ground plane the antenna resonates with two bands having bandwidths of 16.75% and 35.58%.When the same antenna is fed by aperture coupling, three bands occur with bandwidths of 44.3%, 4.75% and 53.43%. Further when the H-slot is replaced with a dumbbell slot all the three bands merge to give single band of 91.43% with a peak gain of 10.23dB while retaining the broadside radiation characteristics. The design concept is presented and experimental results discussed

Multiband Operation of Microstrip Antenna

The effect of proximity and aperture coupling on the resonance behavior of the microstrip antenna is presented. With proximity coupling the antenna resonates with two bands having bandwidths of 16.75% and 35.58%.When the same antenna is fed by aperture coupling, three bands occur with bandwidths of 44.3%, 4.75% and 53.43%. Further when the H-slot is replaced with a dumbbell slot all the three bands merge to give single band of 91.43% with a peak gain of 10.23dB while retaining the broadside radiation characteristics. The design concept is presented and experimental results discussed