Eleketroencefalografski pokazatelji za vrijeme anestezije propofolom i ksilazin-ketaminom u koza

The use of intravenous anaesthesia for short term surgical procedures in animal husbandry practices is increasing. However, information on the quality of an anaesthetic regime in goats has remained inadequate. Therefore, electroencephalographic studies were conducted on twelve apparently healthy adult female Barbari crossbred goats, aged 2 to 4 years, to assess the anaesthetic quality of a propofol and xylazine-ketamine combination. Quantitative analysis of EEG parameters [Total power, Median Frequency, Spectral Edge Frequency 90 (SEF-90) and Relative Power (RP) of different frequency bands delta (δ), theta (θ), alpha (α) and beta (β)] were assessed pre-experimentally (control), and at one, five, 10, 30 min, one hr, and two hr after intravenous propofol (4 mg/kg) and xylazine (0.05 mg/kg)-ketamine (4 mg/kg) administration. After propofol and xylazine-ketamine administration total power, RP-δ and θ increased significantly (P<0.05) while SEF 90, MF, RP-α and RP-β decreased. Most of the EEG changes were adequately depicted in vertex and parietal channels. Spectral analysis of EEG tracings suggested that propofol produced minimum anaesthetic stress and is a safer and better choice for short term anaesthesia in goats.U stočarskoj praksi se za kratkotrajne kirurške zahvate sve više primjenjuje intravenska anestezija. Nedostaju međutim podaci na temelju kojih bi se ustanovila kvaliteta anestezijskog protokola u koza. Kako bi se procijenila kvaliteta kombinacije anestetika propofola i ksilazin-ketamina, provedena je analiza elektoencefalografskih pokazatelja u 12 zdravih odraslih koza. Koze su bili križanci barbari pasmine u dobi od 2 do 4 godine. Kvantitativna analiza EEG pokazatelja (total power, median frequency, SEF-90, relative power delta-δ, theta-θ, alfa-α i beta-β frekvencijskih pojaseva) procijenjeni su prije pokusa (kontrolna skupina), te 1, 5, 10, 30 minuta, jedan sat i dva sata nakon intravenske primjene propofola (4 mg/kg) i ksilazin (0,05 mg/kg)-ketamina (4 mg/kg). Nakon primjene propofola i ksilazin-ketamina total power, te relative power-δ i relative power-θ znakovito su porasli (P < 0,05), dok su se SEF 90, median frequency, relative power-α i relative power-β snizili. Većina EEG promjena odgovarajuće je prikazana u verteksu i parijetalnim kanalima. Spektralna analiza EEG-a upućuje na to da propofol u anestezijskom protokolu uzrokuje minimalan stres te je, u usporedbi sa ksilazin-ketaminom, za kratkotrajnu anesteziju koza sigurniji i bolji izbor