Indapamide retard as the medication of choice in elderly patients with arterial hypertension

The modern society faces a steady increase in the numbers of elderly people, which is associated with a range of social and medical problems. Age-related aspects of body anatomy and physiology, multiple comorbidity, and cognitive decline restrict the choice of medications in elderly patients. The paper discusses the need for the agreement between the choice of antihypertensive agents in elderly patients and the importance of organoprotection. From the evidence-based medicine standpoint, indapamide retard is considered as the medication which meets all the requirements for arterial hypertension treatment in elderly patients

СARDIOPROTECTION IN PATIENTS WITH HYPERTENSION – THE ROLE OF LOSARTAN

In patients with arterial hypertension (HT) heart is affected earlier and more often than other target organs, left ventricular hypertrophy (LVH) develops. Considering the proven link between the presence of LVH and increased cardiovascular risk, the deterioration of the clinical course and prognosis in HT patients, as well as a significant prognosis improvement in patients with LVH decrease, correction of modifiable risk factors (including uncontrolled HT) is getting extremely important. Organoprotective properties of drugs should be taken into account as one of the important parameters in the consideration of antihypertensive therapy. Major studies conducted in recent years have proven cardioprotective and angioprotective properties of angiotensin receptor blocker losartan, so it can be used as first-line therapy in patients with HT and LVH

CYTOKINE ACTIVITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Acute myocardial infarction is a severe cardiovascular pathology. Recent studies have demonstrated that its clinical course depends not only on the size of necrosis zone, but also on the local inflammation activity. In this study, the dynamics of various cytokines (INF-γ, IL-4, IL-6, IL-8, IL-10, IL-12, and TGF-β) in patients with different clinical course and outcome of acute myocardial infarction was investigated. It was shown that cytokine dynamics is similar to the dynamics of other pro-inflammatory factors. Complicated clinical course of myocardial infarction is characterised by manifested cytokine reaction and delayed normalisation of cytokine levels. In fatal myocardial infarction, IL-6 and INF-γ cytokines are suppressed. The evaluation of cytokine reaction in myocardial infarction patients could be used for predicting the clinical course and outcome of the disease