264 research outputs found
Exclusive Charmonium Production at the Electron-ion collider in China
We investigate the exclusive production at the future Electron-ion
collider in China by utilizing the eSTARlight event generator. We model the
cross-section and kinematics by fitting to the world data of
photoproduction. Projected statistical uncertainties on production are
based on the design of a central detector, which consists of a tracker and
vertex subsystem. The precision of the pseudo-data allows us to probe the
near-threshold mechanism, e.g. the re-scattering effect. The significance of
the forward amplitudes is discussed as well. The design and optimization of the
detector enhance the potential for exploring the near-threshold region and the
realm of high four-momentum transfer squared.Comment: 10 pages, 11 figure
Land rebound after banning deep groundwater extraction in Changzhou, China
More than 30 years groundwater overdraft had resulted in hydraulic head declined from near the ground surface to 85 m deep in the second confined aquifer (CA2) in Changzhou, and lead to regional land subsidence from 1970's to early 2000's. After banning deep groundwater extraction was banned in 2000, the hydraulic head of CA2 had recovered to 37.6 m in Changzhou by the end of 2013. Based on several stages first and second order leveling results and long term monitoring data from the multi-strata borehole extensometer station (BES), it was revealed that the land subsidence is attributed to the compression of both aquifers and aquitards in the porous aquifer system. The spatial characteristics of subsidence are related not only to hydraulic head pattern in the area, but also to the thickness and compressibility of different soil strata, and distance from the aquifer. Since banning deep groundwater extraction, the ground uplifted 37.22 mm (5.4% of the pre subsidence) at BES, Changzhou due to the hydraulic head recovering. Strata compression and rebound was recorded as: the upper most stratum, and the underlying aquitard of CA2, and the upper CA3 are still in the compression process, the lower CA3 layer and the upper most segment of aquitard of CA2 rebounded about 90% of the pre compression recorded since 1984, and the CA2 and its adjacent overlying aquitard rebounded 3.8%–9.7% of the pre compression. © 2017 Elsevier B.V
Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus
The protein phosphatase-2A (PP-2A), one of the major phosphatases in eukaryotes, is a heterotrimer, consisting of a scaffold A subunit, a catalytic C subunit and a regulatory B subunit. Previous studies have shown that besides regulating specific PP-2A activity, various B subunits encoded by more than 16 different genes, may have other functions. To explore the possible roles of the regulatory subunits of PP-2A in vertebrate development, we have cloned the PR55/B family regulatory subunits: β and δ, analyzed their tissue specific and developmental expression patterns in Goldfish ( Carassius auratus). Our results revealed that the full-length cDNA for PR55/Bβ consists of 1940 bp with an open reading frame of 1332 nucleotides coding for a deduced protein of 443 amino acids. The full length PR55/Bδ cDNA is 2163 bp containing an open reading frame of 1347 nucleotides encoding a deduced protein of 448 amino acids. The two isoforms of PR55/B display high levels of sequence identity with their counterparts in other species. The PR55/Bβ mRNA and protein are detected in brain and heart. In contrast, the PR55/Bδ is expressed in all 9 tissues examined at both mRNA and protein levels. During development of goldfish, the mRNAs for PR55/Bβ and PR55/Bδ show distinct patterns. At the protein level, PR55/Bδ is expressed at all developmental stages examined, suggesting its important role in regulating goldfish development. Expression of the PR55/Bδ anti-sense RNA leads to significant downregulation of PR55/Bδ proteins and caused severe abnormality in goldfish trunk and eye development. Together, our results suggested that PR55/Bδ plays an important role in governing normal trunk and eye formation during goldfish development
Calibration of the Timing Performance of GECAM-C
As a new member of the Gravitational wave high-energy Electromagnetic
Counterpart All-sky Monitor (GECAM) after GECAM-A and GECAM-B, GECAM-C
(originally called HEBS), which was launched on board the SATech-01 satellite
on July 27, 2022, aims to monitor and localize X-ray and gamma-ray transients
from 6 keV to 6 MeV. GECAM-C utilizes a similar design to GECAM but
operates in a more complex orbital environment. In this work, we utilize the
secondary particles simultaneously produced by the cosmic-ray events on orbit
and recorded by multiple detectors, to calibrate the relative timing accuracy
between all detectors of GECAM-C. We find the result is 0.1 , which
is the highest time resolution among all GRB detectors ever flown and very
helpful in timing analyses such as minimum variable timescale and spectral
lags, as well as in time delay localization. Besides, we calibrate the absolute
time accuracy using the one-year Crab pulsar data observed by GECAM-C and
Fermi/GBM, as well as GECAM-C and GECAM-B. The results are and , respectively. Finally, we investigate the
spectral lag between the different energy bands of Crab pulsar observed by
GECAM and GBM, which is .Comment: submitte
Effect of Qufengtongluo Decoction on PI3K/Akt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy
Ground calibration of Gamma-Ray Detectors of GECAM-C
As a new member of GECAM mission, GECAM-C (also named High Energy Burst
Searcher, HEBS) was launched onboard the SATech-01 satellite on July 27th,
2022, which is capable to monitor gamma-ray transients from 6 keV to 6
MeV. As the main detector, there are 12 gamma-ray detectors (GRDs) equipped for
GECAM-C. In order to verify the GECAM-C GRD detector performance and to
validate the Monte Carlo simulations of detector response, comprehensive
on-ground calibration experiments have been performed using X-ray beam and
radioactive sources, including Energy-Channel relation, energy resolution,
detection efficiency, SiPM voltage-gain relation and the non-uniformity of
positional response. In this paper, the detailed calibration campaigns and data
analysis results for GECAM-C GRDs are presented, demonstrating the excellent
performance of GECAM-C GRD detectors.Comment: third versio
The complete mitochondrial genome of the oriental fruit moth Grapholita molesta (Busck) (Lepidoptera: Tortricidae)
The oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae) currently is one of the economically most destructive pest species of stone and pome fruits worldwide. Here we sequenced the complete mitochondrial genome of this pest. This genome is 15,776 bp long, with an A + T content of 81.24%, containing 37 typical animal mitochondrial genes and an A + T-rich region. All gene are arranged as hypothesized ancestral gene order of insects except for trnM, which was shuffled from 3′ downstream of trnQ to 5′ upstream of trnI. cox1 gene uses unusual CGA start codon, as that in all other sequenced lepidopteran mitochondrial genome. The secondary structures for the two rRNA genes were predicted. All helices typically present in insect mitochondrial rRNA genes are generated. A microsatellite sequence was inserted into the region of H2347 in rrnL in G. molesta and two other sequenced tortricid mitochondrial genomes, indicating that the insertion event in this helix might occurred anciently in family Tortricidae. All of the 22 typical animal tRNA genes have a typical cloverleaf structure except for trnS2, in which the D-stem pairings in the DHU arm are absent. An intergenic sequence is present between trnQ and nad2 as well as in other sequenced lepidopteran mitochondrial genomes, which was presumed to be a remnant of trnM gene and its boundary sequences after the duplication of trnM to the upstream of trnI in Lepidoptera. The A + T-rich region is 836 bp, containing six repeat sequences of “TTATTATTATTATTAAATA(G)TTT.
Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models
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