Examining Knowledge Management Enabled Performance for Hospital Professionals: A Dynamic Capability View and the Mediating Role of Process Capability

Healthcare organizations are essentially associated with highly knowledge-intensive property, and hospital professionals are key to providing high-quality care to patients. KM-enabled performance for hospital professionals is the major concern of senior management. The literature has generally argued for a process-based approach for KM-enabled performance in which process capabilities mediate the link between knowledge resources and performance. According to the knowledge-based view, KM-enabled performance should be rooted in the identification of knowledge resources, including knowledge assets and capabilities. Further, the concept of dynamic capabilities defines an interaction feature between knowledge assets and capabilities. Next, KM-enabled performance is generally defined to include both financial and patient performance. Based on the dynamic capability view and the mediating role of process capability, this research thus proposes a novel research model for exploring KM-enabled performance for hospital professionals, which this includes three major components: interaction between hospital knowledge assets and capabilities, hospital process capabilities, and hospital performance. The empirical results indicate that the model of KM-enabled performance is well fitted with these components, and hospital professionals are closely associated with KM-enabled performance in providing high-quality care

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

Correction to Wu DD, Irwin DM, Zhang YP: Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. BMC Evol Biol 2008, 8:241

On the measurement of the Hubble constant in a local low-density universe

Astrophysical observations indicate that the ``Local Universe" has a relatively lower matter density ($\Omega_0$) than the predictions of the standard inflation cosmology and the large-scale motions of galaxies which provide a mean mass density to be very close to unity. In such a local underdense region the Hubble expansion may not be representative of the global behaviour. Utilizing an underdense sphere embedded in a flat universe as the model of our ``Local Universe", we show that the local Hubble constant would be 1.2 -- 1.4 times larger than the global value on scale of $\sim80$ Mpc, depending on the variation of $\Omega_0$. This may account for the recent measurements of the unpleasantly large Hubble constant of $\sim$80 km/s/Mpc using the Cepheid variables in the Virgo cluster and the relative distance between Virgo and Coma cluster and removes the resulted apparent paradox of the age of our universe.Comment: 9 pages, Latex file, 3 figures available by reques

NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression

<p>Abstract</p> <p>Background</p> <p>Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4^thcommonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action potential and respond to some pathological stimuli, but the function of the cells is still unclear. We assumed the NG2 cells may play an active role in neuropathogenesis and aimed to determine if NG2 cells could sense and response to the alterations in the axonal contents caused by disruption of neurofilament light subunit (NFL) expression.</p> <p>Results</p> <p>In the early neuropathological development stage, our study showed that the diameter of axons of upper motor neurons of NFL-/- mice decreased significantly while the thickness of their myelin sheath increased remarkably. Although there was an obvious morphological distortion in axons with occasionally partial demyelination, no obvious changes in expression of myelin proteins was detected. Parallel to these changes in the axons and their myelination, the processes of NG2 cells were disconnected from the nodes of Ranvier and extended further, suggesting that these cells in the spinal cord white matter could sense the alteration in axonal contents caused by disruption of NFL expression before astrocytic and microglial activation.</p> <p>Conclusion</p> <p>The structural configuration determined by the NFL gene may be important for maintenance of normal morphology of myelinated axons. The NG2 cells might serve as an early sensor for the delivery of information from impaired neurons to the local environment.</p

Identification of alternative splicing variants of the β subunit of human Ca2+/calmodulin-dependent protein kinase II with different activities

AbstractThe β subunit of human Ca2+/calmodulin-dependent protein kinase II (β CaMKII) was identified by searching through an expressed sequence tag database and rapid amplification of cDNA 5′-ends and was assigned to chromosome 7. Reverse transcription-polymerase chain reaction and sequencing analysis identified at least five alternative splicing variants of β CaMKII (β, β6, βe, β′e, and β7) in brain and two of them (β6 and β7) were first detected in any species. When expressed in HEK 293 cells, the Ca2+/calmodulin-dependent kinase activity of β7, the shortest variant, was much lower than that of either β (the longest one) or βe (the medium one), suggesting possible regulation of β CaMKII activity by alternative splicing

Isopropyl 4-nitro­benzoate

In the mol­ecule of the title compound, C10H11NO4, the nitro group is approximately coplanar with the benzene ring [dihedral angle = 4.57 (10)°], while the carboxyl­ate group is slightly twisted, making an angle of 12.16 (8)°. In the crystal, weak inter­molecular C—H⋯O hydrogen bonding and π–π stacking inter­actions [centroid–centroid distances = 3.670 (2) and 3.665 (2) Å] are observed

The Complete Chloroplast Genome of Ginkgo biloba Reveals the Mechanism of Inverted Repeat Contraction

We determined the complete chloroplast genome (cpDNA) of Ginkgo biloba (common name: ginkgo), the only relict of ginkgophytes from the Triassic Period. The cpDNA molecule of ginkgo is quadripartite and circular, with a length of 156,945 bp, which is 6,458 bp shorter than that of Cycas taitungensis. In ginkgo cpDNA, rpl23 becomes pseudo, only one copy of ycf2 is retained, and there are at least five editing sites. We propose that the retained ycf2 is a duplicate of the ancestral ycf2, and the ancestral one has been lost from the inverted repeat A (IRA). This loss event should have occurred and led to the contraction of IRs after ginkgos diverged from other gymnosperms. A novel cluster of three transfer RNA (tRNA) genes, trnY-AUA, trnC-ACA, and trnSeC-UCA, was predicted to be located between trnC-GCA and rpoB of the large single-copy region. Our phylogenetic analysis strongly suggests that the three predicted tRNA genes are duplicates of trnC-GCA. Interestingly, in ginkgo cpDNA, the loss of one ycf2 copy does not significantly elevate the synonymous rate (Ks) of the retained copy, which disagrees with the view of Perry and Wolfe (2002) that one of the two-copy genes is subjected to elevated Ks when its counterpart has been lost. We hypothesize that the loss of one ycf2 is likely recent, and therefore, the acquired Ks of the retained copy is low. Our data reveal that ginkgo possesses several unique features that contribute to our understanding of the cpDNA evolution in seed plants

Multi-Locus Analysis Reveals A Different Pattern of Genetic Diversity for Mitochondrial and Nuclear DNA between Wild and Domestic Pigs in East Asia

BACKGROUND: A major reduction of genetic diversity in mtDNA occurred during the domestication of East Asian pigs. However, the extent to which genetic diversity has been lost in the nuclear genome is uncertain. To reveal levels and patterns of nucleotide diversity and to elucidate the genetic relationships and demographic history of domestic pigs and their ancestors, wild boars, we investigated 14 nuclear markers (including 8 functional genes, 2 pseudogenes and 4 intergenic regions) from 11 different chromosomes in East Asia-wide samples and pooled them with previously obtained mtDNA data for a combined analysis. PRINCIPAL FINDINGS: The results indicated that domestic pigs and wild boars possess comparable levels of nucleotide diversity across the nuclear genome, which is inconsistent with patterns that have been found in mitochondrial genome. CONCLUSIONS: This incongruence between the mtDNA and nuclear genomes is suggestive of a large-scale backcross between male wild boars and female domestic pigs in East Asia. Our data reveal the impacts of founder effects and backcross on the pig genome and help us better understand the complex demographic histories of East Asian pigs, which will be useful for future work on artificial selection

Fluid mud induced by periodic tidal advection and fine-grained sediment settling in the Yangtze estuary

This study presents in-situ observations of fluid mud in the Yangtze Estuary via a bottom tripod. Six occurrences of periodic fluid muds (F1-F6) were observed at high slack water, with suspended sediment concentration (SSC) exceeding 10 kg/m3. The thickness of the fluid mud varied across the six occurrences, reaching a maximum of 0.32m. Notably, temperature and salinity anomalies were observed within the fluid mud. The formation of fluid mud was found to be influenced by turbulence, with turbulence kinetic energy (TKE) below 5×10-4 m2/s2 favoring settling as the primary cause of formation. The critical shear stress (τcw) for fluid mud formation was estimated to be approximately 0.09 Pa. The formation of fluid muds during early tidal cycles was attributed to liquefaction and bed erosion resulting from strong waves. However, in most cases, the wave energy was insufficient for erosion, suggesting that advection played a role in sediment supply during the subsequent tide cycles. The increased cross-channel current velocity during flood facilitated the lateral transport of a significant amount of eroded sediment from shallow water into the channel. Due to its short duration, the fluid mud layer was entrained by the current before consolidation. Enhanced turbulence led to the breakdown of fluid mud at the early ebb. The critical τcw for fluid mud breakdown depended on the density and duration of the fluid mud, with a maximum value of up to 0.70 Pa. The absence of the fluid mud layer during low slack water and neap tide was associated with a reduction in advection and tidal pumping, disrupting the original sediment balance between supply and demand. These data provide valuable insights into the formation and breakdown of fluid mud, contributing to estuarine hydrodynamic modeling studies and enhancing the understanding of estuary dynamics