Endoscopic evaluation by the Kyoto classification of gastritis combined with serum anti-Helicobacter pylori antibody testing reliably risk-stratifies subjects in a population-based gastric cancer screening program

Background　We previously demonstrated that the Kyoto classification of gastritis was useful for judging the status of Helicobacter pylori infection in a population-based screening program, and that adding H. pylori antibody test improved its accuracy (UMIN000028629). Here, we tested whether our endoscopic diagnosis of H. pylori infection status reliably estimated gastric cancer risk in the program. Methods　Data were collected from1345 subjects who underwent endoscopic follow-up 4 years after the end of the registration. We analyzed the association of three diagnostic methods of H. pylori infection with gastric cancer detection: (1) endoscopic diagnosis based on the Kyoto classification of gastritis; (2) serum diagnosis according to the ABC method (H. pylori antibody and pepsinogen I and II); and (3) endoscopic diagnosis together with H. pylori antibody test. Results　During the follow-up, 19 cases of gastric cancer were detected. By Kaplan–Meier analysis, the detection rates of cancer were significantly higher in the past or current H. pylori infection groups than in the never-infected group with all 3 methods. By the Cox proportional hazards model, the hazard ratio for cancer detection was highest in evaluation with the combined endoscopic diagnosis and the antibody test (method 3; hazard ratio 22.6, 95% confidence interval 2.99–171) among the three methods (the endoscopic diagnosis (method 1); 11.3, 2.58–49.8, and the ABC method (method 2); 7.52, 2.49–22.7). Conclusions　Endoscopic evaluation of H. pylori status with the Kyoto classification of gastritis, especially combined with serum anti-Helicobacter pylori antibody testing, reliably risk-stratified subjects in a population-based gastric cancer screening program

SERENADE II: An ALMA Multi-Band Dust-Continuum Analysis of 28 Galaxies at 5<z<85<z<8 and the Physical Origin of the Dust Temperature Evolution

We present an analysis of ALMA multi-band dust-continuum observations for 28 spectroscopically-confirmed bright Lyman-break galaxies at $5<z<8$. Our sample consists of 11 galaxies at $z\sim6$ newly observed in our ALMA program, which substantially increases the number of $5<z<8$ galaxies with both rest-frame 88 and 158 $\mu{\rm m}$ continuum observations, allowing us to simultaneously measure the IR luminosity and dust temperature for a statistical sample of $z\gtrsim5$ galaxies for the first time. We derive the relationship between the UV slope ($\beta_{\rm UV}$) and infrared excess (IRX) for the $z\sim6$ galaxies, and find a shallower IRX-$\beta_{\rm UV}$ relation compared to the previous results at $z\sim2$--4. Based on the IRX-$\beta_{\rm UV}$ relation consistent with our results and the $\beta_{\rm UV}$-$M_{\rm UV}$ relation including fainter galaxies in the literature, we find a limited contribution of the dust-obscured star formation to the total SFR density, $\sim30\%$ at $z\sim6$. Our measurements of the dust temperature at $z\sim6-7$, $T_{\rm dust}=40.9_{-9.1}^{+10.0}\,{\rm K}$ on average, supports a gentle increase of $T_{\rm dust}$ from $z=0$ to $z\sim6$--7. Using an analytic model with parameters consistent with recent {\it{JWST}} results, we discuss that the observed redshift evolution of the dust temperature can be reproduced by an $\sim0.6\,{\rm dex}$ increase in the gas depletion timescale and $\sim0.4\,{\rm dex}$ decrease of the metallicity. The variety of $T_{\rm dust}$ observed at high redshifts can also be naturally explained by scatters around the star-formation main sequence and average mass-metallicity relation, including an extremely high dust temperature of $T_{\rm dust}>80\,{\rm K}$ observed in a galaxy at $z=8.3$.Comment: Submitted to Ap