Refining the Blunt Instruments of Cybersecurity: A Framework to Coordinate Prevention and Preservation of Behaviours

Background. Cybersecurity controls are deployed to manage risks posed by malicious behaviours or systems. What is not often considered or articulated is how cybersecurity controls may impact legitimate users (often those whose use of a managed system needs to be protected, and preserved). This characterises the ‘blunt’ nature of many cybersecurity controls. Aim. Here we present a synthesis of methods from cybercrime opportunity reduction and behaviour change. Method. We illustrate the method and principles with a range of examples and a case study focusing on online abuse and social media controls,relating in turn to issues inherent in cyberbullying and tech-abuse. Results. The framework describes a capacity to improve the precision of cybersecurity controls, identifying opportunities for risk owners to better protect legitimate users while simultaneously acting to prevent malicious activity in a managed system. Conclusions. We describe capabilities for a novel approach to managing sociotechnical cyber-risk, which can be integrated into typical risk management processes, to allow for side-by-side consideration of efforts to prevent and preserve different behaviours in a system, by examining their shared determinants

A Social Network Analysis and Comparison of Six Dark Web Forums

With increasing monitoring and regulation by platforms, communities with criminal interests are moving to the dark web, which hosts content ranging from whistle-blowing and privacy, to drugs, terrorism, and hacking. Using post discussion data from six dark web forums we construct six interaction graphs and use social network analysis tools to study these underground communities. We observe the structure of each network to highlight structural patterns and identify nodes of importance through network centrality analysis. Our findings suggest that in the majority of the forums some members are highly connected and form hubs, while most members have a lower number of connections. When examining the posting activities of central nodes we found that most of the central nodes post in sub-forums with broader topics, such as general discussions and tutorials. These members play different roles in the different forums, and within each forum we identified diverse user profiles.EPSRC Doctoral Training Studentship (Jack Hughes

Microwave assisted heterogeneous catalysis: effects of varying oxygen concentrations on the oxidative coupling of methane

The oxidative coupling of methane was investigated over alumina supported La2O3/CeO2 catalysts under microwave dielectric heating conditions at different oxygen concentrations. It was observed that, at a given temperature using microwave heating, selectivities for both ethane and ethylene were notably higher when oxygen was absent than that in oxygen/methane mixtures. The differences were attributed to the localised heating of microwave radiation resulting in temperature inhomogeneity in the catalyst bed. A simplified model was used to estimate the temperature inhomogeneity; the temperature at the centre of the catalyst bed was 85 °C greater than that at the periphery when the catalyst was heated by microwaves in a gas mixture with an oxygen concentration of 12.5% (v/v), and the temperature difference was estimated to be 168 °C in the absence of oxygen

Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women

Background: The BRCA1 gene is an important breast-cancer susceptibility gene. Promoter polymorphisms can alter the binding affinity of transcription factors, changing transcriptional activity and may affect susceptibility to disease. Methods and Results: Using direct sequencing of the BRCA1 promoter region, we identified four polymorphisms c.-2804T→C (rs799908:T→C), c.-2265C→T (rs11655505:C→T), c.-2004A→G (rs799906:A→G) and c.-1896(ACA) 1→(ACA) 2 (rs8176071:(ACA) 1→(ACA) 2) present in Hong Kong Chinese. Each polymorphism was studied independently and in combination by functional assays. Although all four variants significantly altered promoter activity, the c.-2265T allele had stronger binding than the C allele, and the most common mutant haplotype, which contains the c.-2265T allele, increased promoter activity by 70%. Risk association first tested in Hong Kong Chinese women with breast cancer and age-matched controls and replicated in a large population-based study of Shanghai Chinese, together totalling >3000 participants, showed that carriers of the c.-2265T allele had a reduced risk for breast cancer (combined odd ratio (OR) = 0.80, 95% Cl 0.69 to 0.93; p = 0.003) which was more evident among women aged ≥45 years at first diagnosis of breast cancer and without a family history of breast cancer (combined OR = 0.75, 95% Cl 0.61 to 0.91; p = 0.004). The most common haplotype containing the c.-2265T allele also showed significant risk association for women aged ≥45 years without a family history of breast cancer (OR = 0.64, 95% Cl 0.46 to 0.89; p = 0.008). Conclusion: This comprehensive study of BRCA1 promoter polymorphisms found four variants that altered promoter activity and with the most significant contribution from c.-2265C→T, which could affect susceptibility to breast cancer in the Chinese population. Its significance in other populations remains to be investigated.published_or_final_versio

Serine Phosphoacceptor Sites within the Core Protein of Hepatitis B Virus Contribute to Genome Replication Pleiotropically

The core protein of hepatitis B virus can be phosphorylated at serines 155, 162, and 170. The contribution of these serine residues to DNA synthesis was investigated. Core protein mutants were generated in which each serine was replaced with either alanine or aspartate. Aspartates can mimic constitutively phosphorylated serines while alanines can mimic constitutively dephosphorylated serines. The ability of these mutants to carry out each step of DNA synthesis was determined. Alanine substitutions decreased the efficiency of minus-strand DNA elongation, primer translocation, circularization, and plus-strand DNA elongation. Aspartate substitutions also reduced the efficiency of these steps, but the magnitude of the reduction was less. Our findings suggest that phosphorylated serines are required for multiple steps during DNA synthesis. It has been proposed that generation of mature DNA requires serine dephosphorylation. Our results suggest that completion of rcDNA synthesis requires phosphorylated serines