Validity on tentative design of a regional cooperation system for post-discharge perinatal grief care by the Delphi method

13301甲第4462号博士（保健学）金沢大学博士論文要旨Abstract 以下に掲載：金沢大学つるま保健学会誌 40(1) pp.21-33 2016. 金沢大学つるま保健学会. 共著者：米田 昌代, 島田 啓

Steroidogenesis in Isolated Adrenal Cells of Rat

A reliable and reproducible system for the isolation of rat adrenal cells was developed, using 0.25% trypsin for cell dispersion. The suspending cell in Krebs-Ringer bicarbonate buffer containing 0.2% glucose and 0.5% bovine serum albumin was incubated for 120 minutes at 37℃ under 95% 02 and 5% C02. Corticosterone production induced by synthetic 1-24ACTH showed a dose-related increase in decapsular cells. The precision of the inter-experiment of corticosterone production was 5.0% (average coefficients of variation)

The relationship between S-wave reflectors and deep low-frequency earthquakes in the northern Kinki district, southwestern Japan

Abstract We conducted high-resolution reflection analysis of data from 168 seismic stations with an average spacing of about 5 km, in northern Kinki district, southwestern Japan. Reflection analysis has previously been conducted in this region, assuming a homogeneous horizontal structure, resulting in an inclined planar zone of high relative reflection strengths (S-wave reflector). However, if the reflector is actually inclined, the location of the S-wave reflector differs from that of an assumed homogeneous horizontal structure. Hence, this study conducted high-resolution reflection analysis to determine the accurate location of the S-wave reflector. We confirm the previously reported S-wave reflector (reflector W). Furthermore, we detected the accurate location of the S-wave reflector and obtained more detailed results that revealed a second S-wave reflection structure (reflector E) to the east of reflector W, in an area that has not be imaged by previous studies. The northern edges of reflector E and reflector W are located near different hypocentral areas of deep low-frequency earthquakes (DLFs). Reflector W exists along the Kyoto Nishiyama fault zone, and its position appears to change along the fault zone as it deepens. Similarly, reflector E exists along the Hanaore and Biwako Seigan fault zones and its position appears to change along these fault zones. The reflector W and reflector E are imaged as separate S-wave reflectors in deeper regions, but they coalesce in shallower regions. According to previous studies, crustal fluid by dehydration from the Philippine Sea plate exists near these epicenters and we infer that this crustal fluid causes DLFs and forms S-wave reflectors

Correction to: Which is heterogeneous, stress or strength? An estimation from high-density seismic observations

Abstract After publication of this work [1], an error was noticed. Figures 10 and 12 were accidentally swapped. This was caused due to a typesetting error. This is now corrected below: The publisher apologises for these errors

Which is heterogeneous, stress or strength? An estimation from high-density seismic observations

The Correction to this article has been published in Earth, Planets and Space 2018 70:20.Using data from high-density seismic observation networks installed in the western Nagano Prefecture region in Japan, we precisely determined focal mechanisms and estimated the high-resolution stress field at a scale of 1 km. Almost all differences between observed and calculated slip directions (misfit) were smaller than the errors in focal mechanisms at grid points away from the mainshock fault. This finding clearly indicates that the estimated uniform stress suitably explains focal mechanisms in each subregion apart from the mainshock fault. Misfits are relatively large at grid points near the mainshock fault, but many of these misfits are smaller than the errors in focal mechanisms, and stress is regarded as uniform for a greater portion within each subregion. However, we found that focal mechanisms and P-axes varied widely and differed from each other for a short focal distance of 100 m. These results clearly show that stress can be regarded as uniform, but that strength is heterogeneous

Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats

Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously revealed that pre-treatment with yohimbine or JP-1302 attenuated renal ischemia/reperfusion injury by inhibition of α2C-adrenoceptor antagonist. The aim of the present study is to investigate the effects of post-treatment with JP-1302 on renal ischemia/reperfusion injury in rats. Male Sprague Dawley rats were randomly divided into four groups: sham operation, ischemia/reperfusion, pre-treatment with JP-1302 (3.0 mg/kg) and post-treatment with JP-1302 groups. In ischemia/reperfusion injury, renal functional parameters, such as blood urea nitrogen, plasma creatinine and creatinine clearance, deteriorated after reperfusion. Renal venous norepinephrine concentrations, as well as inflammatory molecules in the kidney increased after reperfusion. Both pre- and post-treatment with JP-1302 improved renal dysfunction, tissue damage, renal venous norepinephrine concentrations and inflammatory molecules expression in the kidney. In conclusion, these results suggest that post-treatment with JP-1302 protects on ischemia/reperfusion-induced acute kidney injury by suppressing cytokine upregulation via α2C-adrenoceptors. Keywords: JP-1302, Ischemia/reperfusion, Acute kidney injury, α2C-adrenoceptor, Norepinephrin