ÓLEO ESSENCIAL DA CASCA DE OCOTEA CATHARINENSIS MEZ. (LAURACEAE)

Pela cromatografia a gás/espectrometria de massa (CGjEM), foram identificados 10 componentes do óleo essencial da casca de Ocotea catharinensis Mez. (Lauraceae), coletada no Parque Estadual da Cantareira (Pinheirinho - São Paulo, Capital), do Instituto Florestal . A destilação pelo método de CLEVENGER forneceu rendimento de 1,34% em óleo essencial. Os componentes identificados foram: α -Pineno (0,07%), Limoneno (0,11 %), 1,8-Cineol (0,14%), óxido-3.6-Linalol (0,36%), Copaeno (0,08%), Linalol (95,76% ),α-Terpineol (1,47%), Sesquiterpeno (M+204) (0,12%), β-Citronelol (0,28%) e Geraniol (0,75%)

Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis

Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.Supporting information available online at http://www.thieme-connect.de/products This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.)

ÓLEO ESSENCIAL DE pimenta pseudocaryophyllus varo pseudocaryophyllus (Gomes) Landrum (MYRTACEAE) I: CROMATOGRAFIA A GÁS/ESPECTROMETRIA DE MASSA (CG/EM)

As folhas de Pimenta pseudocaryophyllus varo pseudocaryophyllus (Gomes) Landrum (Myrtaceae), coletadas no Parque Estadual de Campos do Jordão do Instituto Florestal, foram submetidas à destilação pelo método de CLEVENGER, obtendo-se rendimento em óleo essencial de 2,1% (p/v). Pela cromatografia a gás/espectrometría de massa (CG/EM), foram identificados como principais componentes: geranial (34,26%); neral (27,85%); linaloI (5,18%); geraniol (4,82%); B-cariofileno (4,40%); B-pineno (2,67%); 6-metil -5-hepteno -2-ona (1,58%); a-copaeno (1,55%); 8 -cadineno (1,38%) e a -pineno (1,35%)