Effects of Spartina alterniflora invasion on distribution of Moerella iridescens in a tidal flat of western Pacific Ocean

The invasion of Spartina alterniflora significantly affected the local ecosystem of Western Pacific Ocean where Moerella iridescens lives. Five patches with different invasion stages of S. alterniflora were selected and the influence on distribution of M. iridescens was studied on the coast of Wenzhou Bay, China in 2007. The aggregated distribution pattern was proved by using Taylor's power regression and Iwao's plot regression methods (p<0.001). The densities were significantly affected by the factors of S. alterniflora invasion stage and season (p<0.001), but no significant effect of interaction (p=0.805) occurred. M. iridescens mainly clumped in the habitats of no invasion and initial invasion of S. alterniflora was in the high tidal zone, and the lowest density was recorded where complete invasion occurred. The densities were larger in warmer than in cooler seasons. There were significant positive correlations among the average densities in seasons. Density variation must be the response of M. iridescens to the environment, including S. alterniflora invasion stage, temperate stress and interspecific associations

Effect of Land-Use Change on the Changes in Human Lyme Risk in the United States

The spatial extent and incidence of Lyme disease is increasing in the United States, particularly in the Upper Midwest and Northeast. Many previous studies have explored the drivers of its spatial pattern, however, few studies tried to explore the drivers for the changes of Lyme disease. We here compared the spatial patterns of changes of human Lyme cases and incidence in the Northeast and Upper Midwest between 2003–2005 and 2015–2017, and applied two different approaches (i.e., a statistical regularization approach and model averaging) to investigate the climatic and landscape factors affecting the risk change between the two periods. Our results suggested that changes in land-use variables generally showed different relationships with changes of human Lyme risk between the two regions. Changes of variables related to human-use areas showed opposite correlations in two regions. Besides, forest area and forest edge density generally negatively correlated with the change of human Lyme risk. In the context of ongoing habitat change, we consider this study may provide new insight into understanding the responses of human Lyme disease to these changes, and contribute to a better prediction in the future

Cell type specificity of signaling: View from membrane receptors distribution and their downstream transduction networks.

Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities. To overview the specificity of cell signaling, we integrated human receptome data with proteome spatial expression profiles to systematically investigate the specificity of receptors and receptor-triggered transduction networks across 62 normal cell types and 14 cancer types. Six percent receptors showed cell-type-specific expression, and 4% signaling networks presented enriched cell-specific proteins induced by the receptors. We introduced a concept of &quot;response context&quot; to annotate the cell-type dependent signaling networks. We found that most cells respond similarly to the same stimulus, as the &quot;response contexts&quot; presented high functional similarity. Despite this, the subtle spatial diversity can be observed from the difference in network architectures. The architecture of the signaling networks in nerve cells displayed less completeness than that in glandular cells, which indicated cellular-context dependent signaling patterns are elaborately spatially organized. Likewise, in cancer cells most signaling networks were generally dysfunctional and less complete than that in normal cells. However, glioma emerged hyper-activated transduction mechanism in malignant state. Receptor ATP6AP2 and TNFRSF21 induced rennin-angiotensin and apoptosis signaling were found likely to explain the glioma-specific mechanism. This work represents an effort to decipher context-specific signaling network from spatial dimension. Our results indicated that although a majority of cells engage general signaling response with subtle differences, the spatial dynamics of cell signaling can not only deepen our insights into different signaling mechanisms, but also help understand cell signaling in disease

Partial silencing of the NEC1 gene results in early opening of anthers in Petunia hybrida

The NEC1 gene, previously isolated from Petunia hybrida, is expressed at high levels in nectaries, and in a very localized fashion in stamens, particularly in the anther stomium cells and the upper part of the filament. To elucidate the function of the NEC1 gene, co-suppression was employed for down-regulation of NEC1 expression, and transposon insertion mutagenesis was used to knock out the NEC1 function. Among the transgenic plants and plants carrying dTph1 inserted in the NEC1 gene, an "early open anther" phenotype was observed. In this mutant phenotype, the anthers already open in young flower buds (1.8 cm) that still contain immature pollen, resulting in poor pollen quality and impaired pollen release. The results obtained indicate that NEC1 might be involved in the development of stomium cells, which are ruptured during the normal process of anther dehiscence to release mature pollen. Southern analysis revealed the presence of a highly homologous NEC1-like gene, named NEC2, in the P. hybrida genome. The presence of NEC2 was confirmed by segregation analysis and sequencing of genomic clones. The implications of these results and possible reasons why no visually obvious phenotype in nectaries could be produced by co-suppression or transposon insertion mutagenesis are discussed