Pengaruh Kegiatan Wisata terhadap Perubahan Penggunaan Lahan di Kecamatan Tawangmangu, Kabupaten Karanganyar

Karanganyar is one of regency in Central Java province which it's potential tourist destinations are quite diverse. Nature destinations is one of the tourism assets which commonly found in Karanganyar, facts shown that the existing landscape conditions vary widely from highland terrain to the landscape of coastal lowland forest. Tourism sector contributes in a significance economic scale towards local incomes of Karanganyar Regency. One district which became the center of tourism activities development is Tawangmangu. Tawangmangu district has an integrated tourism destination named Kawasan Wisata Tawangmangu, which consist of several tourism place option like Grojogan Sewu Waterfall, Sapta Tirta, Campgrounds Sekipan, and Taman Ria Balekambang. Because it is the main area of tourism destination in Karanganyar, adequate infrastructure is available and regularly upgraded in the annual basis, because those improvements is needed to support massive tourism activities which might occurred. With the tourism activities development such as newly constructed infrastructure or addition of a few supporting facilities will certainly give effect to the land use transformation of those aforementioned surroundings. This study aimed to analyze the effects of tourism activities towards land use transformation and analyze the causes of changes regarding land use in the Tawangmangu District. In the process of answering these objectives, this study used descriptive qualitative approach. Research on the effects of tourism activities is based on four main analysis, which is tourism characteristic activities, land use transformation, effects of tourism activities towards land use transformation, and the causes of effect of land use transformation. From those four baseline analysis, result shows that tourism activities which has been occurred so far only affects certain areas of Kalisoro, Tawangmangu, and Blumbang. As for the case of land use transformation, in other villages they are not affected by the existence of tourism activities. Besides tourism, land use transformation in the Tawangmangu District also caused by environmental quality, land values, accessibility, also availability of basic decent facilities and infrastructure

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan

The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies. After the first publications, mainly devoted to the preparation and characterization of PUL nanogels, a remarkable number of studies demonstrated how wide can be the field of applications within the main topic of biopharmaceutics. Numerous hydrophilic and lipophilic drugs were entrapped in the nanogel networks, consequently PUL nanogels have been proposed as delivery systems for single drugs and for combination therapies which allowed improvements of pharmacological activities and patient compliance. Furthermore, the large amount of water content allowed loading also proteins which could maintain their native structure and properties. Stimuli-sensitive and stealth PUL nanogel formulations allowed improving the performances of antitumor drugs. These nanohydrogels have also been studied for imaging techniques and for vaccines to be administered by injection and by mucosal application. The studies on PUL nanogels are still in progress and the perspectives for future researches are also addressed

Perbedaan Efektivitas Senam Jantung Sehat dan Senam Lansia terhadap Penurunan Tekanan Darah pada Pasien Hipertensi di Puskesmas Nusa Indah Kota Bengkulu Tahun 2018

Hipertensi adalah penyakit kelainan jantung dan pembuluh darah yang ditandai dengan peningkatan tekanan darah. Salah satu terapi non farmakologi hipertensi adalah olahraga. Senam lansia adalah serangkaian gerak nada yang teratur dan terarah serta terencana yang dilakukan secara tersendiri atau kelompok. Tujuan penelitian untuk mempelajari perbedaan efektivitas senam lansia dan senam jantung sehat terhadap penurunan tekanan darah pada pasien hipertensi di Puskesmas Nusa Indah Kota Bengkulu tahun 2018. Penelitian ini menggunakan rancangan quasi eksperimental pre and post test. Populasi dalam penelitian ini adalah seluruh pasien hipertensi pada anggota senam di Puskesmas Nusa Indah Kota Bengkulu tahun 2018. Pengambilan sampel diambil dari seluruh populasi. Hasil penelitian menggunakan uji Shapiro-Wilk menunjukkan bahwa nilai p = 0,247 (>a=0,05) artinya tidak ada perbedaan efektivitas senam lansia dan senam jantung sehat terhadap penurunan tekanan darah sistolik pada pasien hipertensi di Puskesmas Nusa Indah Kota Bengkulu tahun 2018. Nilai p = 0,450 (>a=0,05) artinya tidak ada perbedaan efektivitas senam lansia dan senam jantung sehat terhadap penurunan tekanan darah diastolik pada pasien hipertensi di Puskesmas Nusa Indah Kota Bengkulu tahun 2018. Diharapkan kepada pasien hipertensi untuk lebih teratur mengikuti kegiatan senam dalam menjaga kestabilan tekanan darah

Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives

Tricyclic isotaxane and taxane derivatives and have been synthesized by a very efficient cascade ring-closing dienyne metathesis (RCDEYM) reaction, which formed the A and B rings in one operation. When the alkyne is present at C13 (with no neighboring gem-dimethyl group), the RCEDYM reaction leads to 14,15-isotaxanes 16a,b and 18b with the gem-dimethyl group on the A ring. If the alkyne is at the C11 position (and thus flanked by a gem-dimethyl group), RCEDYM reaction only proceeds in the presence of a trisubstituted olefin at C13, which disfavors the competing diene ring-closing metathesis reaction, to give the tricyclic core of Taxol 44

Socially-mediated arousal and contagion within domestic chick broods

Emotional contagion – an underpinning valenced feature of empathy – is made up of simpler, potentially dissociable social processes which can include socially-mediated arousal and behavioural/physiological contagion. Previous studies of emotional contagion have often conflated these processes rather than examining their independent contribution to empathic response. We measured socially-mediated arousal and contagion in 9-week old domestic chicks (n = 19 broods), who were unrelated but raised together from hatching. Pairs of observer chicks were exposed to two conditions in a counterbalanced order: air puff to conspecifics (AP) (during which an air puff was applied to three conspecifics at 30 s intervals) and control with noise of air puff (C) (during which the air puff was directed away from the apparatus at 30 s intervals). Behaviour and surface eye temperature of subjects and observers were measured throughout a 10-min pre-treatment and 10-min treatment period. Subjects and observers responded to AP with increased freezing, and reduced preening and ground pecking. Subjects and observers also showed reduced surface eye temperature - indicative of stress-induced hyperthermia. Subject-Observer behaviour was highly correlated within broods during both C and AP conditions, but with higher overall synchrony during AP. We demonstrate the co-occurrence of socially-mediated behavioural and physiological arousal and contagion; component features of emotional contagion

Quantitative Imaging Assessment of Bioresorbable Scaffolds: Preprocedural Sizing and Acute Performance

The use of bioresorbable scaffolds has several challenges that justify careful assessment of this technology. In the randomised comparison, the Absorb everolimuseluting bioresorbable scaffolds showed similar one-year clinical outcomes to the everolimus-eluting Xience metallic stent, and side branch occlusion and other angiographic complications are not different in the acute performance. Implantation of an oversized Absorb scaffold in a relatively small vessel appears to be associated with a higher 1-year MACE rate driven by more frequent early MI. In the early Absorb studies, several failure modes of bioresorbable scaffolds were documented. To avoid scaffold dislodgement, appropriate lesion preparation is mandatory. In case of unsuccessful initial delivery, a second insertion of the same scaffold should be avoided. Adherence to antiplatelet therapy is of paramount importance to avoid acute or subacute scaffold thrombosis. QCA bifurcation was validated and clinical applicable. IVUS, OCT and MSCT could be used to assess long term bioresorption and serial changes in lumen dimension. Further investigation using intravascular imaging is needed to establish the relationship between acute potential mechanism and late adverse events