THE ROLE OF PROTOCOL BIOPSIES IN EARLY PERIOD AFTER KIDNEY TRANSPLANTATION

46 protocol graft biopsies with the subsequent histological examination were performed in 39 patients after kidney transplantation. In 20 patients with stable graft function acute subclinical rejection were revealed in 12 (60%) with the following steroid therapy. In 19 patients with delayed kidney graft function acute rejection was revealed in 13 (68,4%). Treatment by steroids was successful and function renewed. Our results showed that protocol biopsy is a safe and reliable method that allows to recognize such kidney graft pathology as subclinical rejection and to perform its treatment in time

ЗНАЧЕНИЕ ПРОТОКОЛЬНЫХ БИОПСИЙ В РАННЕМ ПЕРИОДЕ ПОСЛЕ ТРАНСПЛАНТАЦИИ ПОЧКИ

46 protocol graft biopsies with the subsequent histological examination were performed in 39 patients after kidney transplantation. In 20 patients with stable graft function acute subclinical rejection were revealed in 12 (60%) with the following steroid therapy. In 19 patients with delayed kidney graft function acute rejection was revealed in 13 (68,4%). Treatment by steroids was successful and function renewed. Our results showed that protocol biopsy is a safe and reliable method that allows to recognize such kidney graft pathology as subclinical rejection and to perform its treatment in time. У 39 больных с пересаженной почкой было проведено 46 протокольных (плановых) биопсий с последующим патогистологическим исследованием полученного материала. Из 20 больных со стабильной функцией трансплантата у 12 (60%) была выявлена острая реакция отторжения и проведена стероидная пульс-терапия. Из 19 больных с отсроченной функцией острое отторжение выявлено у 13 (68,4%), лечение пульсовыми дозами кортикостероидов оказалось эффективным, функция быстро восстановилась. Результаты показали, что протокольная биопсия почечных трансплантатов является безопасным методом исследования. Она позволяет выявлять субклинические острые отторжения и своевременно назначать лечение, которое является эффективным.