Single Transverse-Spin Asymmetry in Large PTP_T Open Charm Production at an Electron-Ion Collider

We discuss the single transverse-spin asymmetry (SSA) to be observed in the $D$-meson production with large transverse-momentum in semi-inclusive deep inelastic scattering, $e p^\uparrow \rightarrow e D X$. This contribution is embodied as a twist-3 mechanism in the collinear factorization, which is induced by purely gluonic correlation inside the transversely-polarized nucleon, in particular, by the three-gluon correlation effects. The complete formula for the corresponding SSA in the leading-order QCD is expressed in terms of the four independent gluonic correlation functions and reveals the five independent structures with respect to the dependence on the azimuthal angle for the produced $D$-meson. We present the numerical calculations of the SSA formula at the kinematics relevant to a future Electron Ion Collider.Comment: 16 pages, 7 figure

On the contribution of twist-3 multi-gluon correlation functions to single transverse-spin asymmetry in SIDIS

We study the single spin asymmetry (SSA) induced by purely gluonic correlation inside a nucleon, in particular, by the three-gluon correlation functions in the transversely polarized nucleon, $p^\uparrow$. This contribution is embodied as a twist-3 mechanism in the collinear factorization framework and controls the SSA to be observed in the $D$-meson production with large transverse-momentum in semi-inclusive DIS (SIDIS), $ep^\uparrow \rightarrow eDX$. We define the relevant three-gluon correlation functions in the nucleon, and determine their complete set at the twsit-3 level taking into account symmetry constraints in QCD. We derive the single-spin-dependent cross section for the $D$-meson production in SIDIS, taking into account all the relevant contributions at the twist-3 level. The result is obtained in a manifestly gauge-invariant form as the factorization formula in terms of the three-gluon correlation functions and reveals the five independent structures with respect to the dependence on the azimuthal angle for the produced $D$ meson. We also demonstrate the remarkable relation between the twist-3 single-spin-dependent cross section and twist-2 cross sections for the $D$-meson production, as a manifestation of universal structure behind the SSA in a variety of hard processes.Comment: 8 pages, 2 figures. To appear in the proceedings of the 19th International Spin Physics Symposium (SPIN2010), Juelich, Germany, Sept.27 - Oct.2, 201

Contribution of Twist-3 Multi-Gluon Correlation Functions to Single Spin Asymmetry in Semi-Inclusive Deep Inelastic Scattering

As a possible source of the single transverse spin asymmetry, we study the contribution from purely gluonic correlation represented by the twist-3 ``three-gluon correlation" functions in the transversely polarized nucleon. We first define a complete set of the relevant three-gluon correlation functions, and then derive its contribution to the twist-3 single-spin-dependent cross section for the $D$-meson production in semi-inclusive deep inelastic scattering, which is relevant to determine the three-gluon correlations. Our cross-section formula differs from the corresponding result in the literature, and the origin of the discrepancy is clarified.Comment: 29 pages, 3 figures minor corrections; version to appear in Phys. Rev.

"Acute pseudo-pericardial tamponade": the compression of the thoracal inferior vena cava – a case report

We describe a case of 68-year-old woman which was admitted to our hospital for mitral valve replacement (MVR), in whom acute compresion of the vena cava inferior developed after repair of lacerated atrio-caval junction with hemostatic tissue sealant, biologic glue (BioGlue, Cryolife, ınc, Kennesaw, Ga). Removal of the BioGlue relieved the unexpected problem

Gauge links for transverse momentum dependent correlators at tree-level

In this paper we discuss the incorporation of gauge links in hadronic matrix elements that describe the soft hadronic physics in high energy scattering processes. In this description the matrix elements appear in soft correlators and they contain non-local combinations of quark and gluon fields. In our description we go beyond the collinear approach in which case also the dependence on transverse momenta of partons is taken into consideration. The non-locality in the transverse direction leads to a complex gauge link structure for the full process, in which color is entangled, even at tree-level. We show that at tree-level in a 1-parton unintegrated (1PU) situation, in which only the transverse momentum of one of the initial state hadrons is relevant, one can get a factorized expression involving transverse momentum dependent (TMD) distribution functions. We point out problems at the level of two initial state hadrons, even for relatively simple processes such as Drell-Yan scattering.Comment: 25 pages, corrected typos and updated reference

MicroRNAs in pulmonary arterial remodeling

Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular remodeling leading to intimal lesions, resulting in elevated pulmonary vascular resistance and right heart dysfunction. Mutations within the bone morphogenetic protein receptor 2 gene, leading to dysregulated proliferation of pulmonary artery smooth muscle cells, have been identified as being responsible for heritable PAH. Indeed, the disease is characterized by excessive cellular proliferation and resistance to apoptosis of smooth muscle and endothelial cells. Significant gene dysregulation at the transcriptional and signaling level has been identified. MicroRNAs are small non-coding RNA molecules that negatively regulate gene expression and have the ability to target numerous genes, therefore potentially controlling a host of gene regulatory and signaling pathways. The major role of miRNAs in pulmonary arterial remodeling is still relatively unknown although research data is emerging apace. Modulation of miRNAs represents a possible therapeutic target for altering the remodeling phenotype in the pulmonary vasculature. This review will focus on the role of miRNAs in regulating smooth muscle and endothelial cell phenotypes and their influence on pulmonary remodeling in the setting of PAH

Transverse Momentum Dependent Parton Distribution/Fragmentation Functions at an Electron-Ion Collider

We present a summary of a recent workshop held at Duke University on Partonic Transverse Momentum in Hadrons: Quark Spin-Orbit Correlations and Quark-Gluon Interactions. The transverse momentum dependent parton distribution functions (TMDs), parton-to-hadron fragmentation functions, and multi-parton correlation functions, were discussed extensively at the Duke workshop. In this paper, we summarize first the theoretical issues concerning the study of partonic structure of hadrons at a future electron-ion collider (EIC) with emphasis on the TMDs. We then present simulation results on experimental studies of TMDs through measurements of single spin asymmetries (SSA) from semi-inclusive deep-inelastic scattering (SIDIS) processes with an EIC, and discuss the requirement of the detector for SIDIS measurements. The dynamics of parton correlations in the nucleon is further explored via a study of SSA in D (`D) production at large transverse momenta with the aim of accessing the unexplored tri-gluon correlation functions. The workshop participants identified the SSA measurements in SIDIS as a golden program to study TMDs in both the sea and valence quark regions and to study the role of gluons, with the Sivers asymmetry measurements as examples. Such measurements will lead to major advancement in our understanding of TMDs in the valence quark region, and more importantly also allow for the investigation of TMDs in the sea quark region along with a study of their evolution.Comment: 44 pages 23 figures, summary of Duke EIC workshop on TMDs accepted by EPJ

Dietary algae and HIV/AIDS: proof of concept clinical data

Dietary algae have been reported to decrease HIV viral fusion/entry and replication and increase immune response, suggesting that regular consumption of algae by people in Japan, Korea, and Chad could be an important factor in their relatively low HIV/AIDS rates. Five antiretroviral-naïve people with HIV (three females, two males; five African Americans) living in Columbia SC participated in the phase I study of acute toxicity. Subjects were randomly assigned to 5 g day-1 brown seaweed (Undaria pinnatifida), Spirulina (Arthrospira platensis), or a combination of both. Endpoints included HIV viral load, complete blood count (CBC), metabolic and lipid panel, and quality of life questionnaire data. When no short-term toxicities were observed, six additional subjects (four females, two males; five African Americans, one Latina) were recruited to further evaluate short- and long-term toxicities (phase II). No adverse effects were observed for the 11 subjects in the phase I trial, and quality of life indicators improved at 3 weeks. No significant changes were observed in CBC, metabolic or lipid panel analyses. CD4 cells (milliliters) and HIV-1 viral load remained stable over the first 3-month phase II study period. One subject continued in the study for 13 months and had clinically significant improvement in CD4 (>100 cells mL−1) and decreased HIV viral load of 0.5 log10. Our pilot data suggest that Undaria, Spirulina, and a combination of both were nontoxic and over time may improve clinical endpoints of HIV/AIDS

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and differentiation in 3T3-L1 cells. In this study, to explore the function of polyamines in adipogenesis, we examined the effect of polyamine biosynthesis inhibitors on adipocyte differentiation and lipid accumulation of 3T3-L1 cells. The spermidine synthase inhibitor trans-4-methylcyclohexylamine (MCHA) increased spermine/spermidine ratios, whereas the spermine synthase inhibitor N-(3-aminopropyl)-cyclohexylamine (APCHA) decreased the ratios in the cells. MCHA was found to decrease lipid accumulation and GPDH activity during differentiation, while APCHA increased lipid accumulation and GPDH activity indicating the enhancement of differentiation. The polyamine-acetylating enzyme, spermidine/spermine N1-acetyltransferase (SSAT) activity was increased within a few hours after stimulus for differentiation, and was found to be elevated by APCHA. In mature adipocytes APCHA decreased lipid accumulation while MCHA had the opposite effect. An acetylpolyamine oxidase and spermine oxidase inhibitor MDL72527 or an antioxidant N-acetylcysteine prevented the promoting effect of APCHA on adipogenesis. These results suggest that not only spermine/spermidine ratios but also polyamine catabolic enzyme activity may contribute to adipogenesis