20 research outputs found
Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro
Preoperative radiochemotherapy treatment in advanced rectal carcinoma. Results of 8-year follow up
Preoperative radiochemotherapy treatment in advanced rectal carcinoma. Results of 8-year follow up
DEVELOPMENT AND BIOFIDELITY EVALUATION OF AN OCCUPANT BIOMECHANICAL MODEL OF A CHINESE 50TH PERCENTILE MALE FOR SIDE IMPACT
Environmental extreme temperature and daily preterm birth in Sabzevar, Iran: a time-series analysis
Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk
Insulin-like growth factor-I (IGF-I) is an important growth factor associated with increased risk of premenopausal breast cancer. We conducted a randomized, placebo-controlled, double-blind, crossover trial to evaluate whether tomato-derived lycopene supplementation (30 mg/day for 2 mo) decreases serum levels of total IGF-I in premenopausal women with 1) a history of breast cancer (n = 24) or 2) a high familial breast cancer risk (n = 36). Also, IGF binding protein (IGFBP) increasing effects were evaluated. Lycopene supplementation did not significantly alter serum total IGF-I and other IGF system components in the 2 study populations combined. However, statistically significant discordant results were observed between the 2 study populations (i.e., P <0.05 for total IGF-I, free IGF-I, and IGFBP-3). Total IGF-I and IGFBP-3 were increased in the breast cancer survivor population [total IGF-I = 7.0%, 95% confidence interval (CI) = -0.2 to 14.3%; IGFBP-3 = 3.3%, 95% CI = 0.7-6.0%), and free IGF-I was decreased in the family history population (-7.6 %, 95 % Cl = -14.6 to -0.6 %). This randomized controlled trial shows that 2 mo of lycopene supplementation has no effect on serum total IGF-I in the overall study population. However, lycopene effects were discordant between the 2 study populations showing beneficial effects in high-risk healthy women but not in breast cancer survivors