21 research outputs found
Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial
Clinicopathological study of pineal parenchymal tumors: correlation between histopathological features, proliferative potential, and prognosis
miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects
Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7/GDF5/SMAD and p38 MAPK signaling pathway
Tumors of pineal cell origin
Tumors of pineal cell origin are rare intracranial lesions. They are the second most common entity encountered in the pineal gland, after tumors of germ cell origin. They are classified according to their differentiation in pineocytomas (World Health Organization [WHO] grade I tumor), pineal parenchymal tumors of intermediate differentiation, papillary tumors of the pineal region, and pineoblastomas (WHO grade 4 tumor). Differentiation between pineal and germ cell tumors is essential, and for this purpose serum and cerebrospinal fluid (CSF) markers are used, alongside imaging techniques. Often, the only way to differentiate these two types of tumors is through a biopsy, which may be carried out with or without a simultaneous third ventriculocisternostomy. Retrospective series show an association between the extent of resection and improved outcomes, and benign lesions may be cured by performing a gross total resection. However, the approaches to this region are highly complex, because of the plethora of essential neuroanatomical structures in the area. The approaches need to be tailored to the specific anatomy of the patient and should aim at minimizing surgical morbidity. Because of their complexity, these lesions should mainly be performed in centers with sufficient experience in the treatment of pineal region lesions.</p