14,781 research outputs found
How do Neutrinos Propagate ? - Wave-Packet Treatment of Neutrino Oscillation
The wave-packet treatment of neutrino oscillation developed previously is
extended to the case in which momentum distribution functions are taken to be a
Gaussian form with both central values and dispersions depending on the mass
eigenstates of the neutrinos. It is shown among other things that the velocity
of the neutrino wave packets does not in general agree with what one would
expect classically and that relativistic neutrinos emitted from pions
nevertheless do follow, to a good approximation, the classical trajectory.Comment: 13 page. No figure. Typeset using PTPTeX.st
Recombination and Population Mosaic of a Multifunctional Viral Gene, Adeno-Associated Virus cap
Homologous recombination is a dominant force in evolution and results in genetic mosaics. To detect evidence of recombination events and assess the biological significance of genetic mosaics, genome sequences for various viral populations of reasonably large size are now available in the GenBank. We studied a multi-functional viral gene, the adeno-associated virus (AAV) cap gene, which codes for three capsid proteins, VP1, VP2 and VP3. VP1-3 share a common C-terminal domain corresponding to VP3, which forms the viral core structure, while the VP1 unique N-terminal part contains an enzymatic domain with phospholipase A2 activity. Our recombinant detection program (RecI) revealed five novel recombination events, four of which have their cross-over points in the N-terminal, VP1 and VP2 unique region. Comparison of phylogenetic trees for different cap gene regions confirmed discordant phylogenies for the recombinant sequences. Furthermore, differences in the phylogenetic tree structures for the VP1 unique (VP1u) region and the rest of cap highlighted the mosaic nature of cap gene in the AAV population: two dominant forms of VP1u sequences were identified and these forms are linked to diverse sequences in the rest of cap gene. This observation together with the finding of frequent recombination in the VP1 and 2 unique regions suggests that this region is a recombination hot spot. Recombination events in this region preserve protein blocks of distinctive functions and contribute to convergence in VP1u and divergence of the rest of cap. Additionally the possible biological significance of two dominant VP1u forms is inferred
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species
Background: The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses. A human-tropic PERV subgroup, PERV-A, can enter human cells through either of two homologous multitransmembrane proteins, huPAR-1 and huPAR-2. Here, we characterised human PARs and their homologues in the PERV-A resistant rodent species, mouse and rat ( muPAR and ratPAR, respectively).
Results: Upon exogenous expression in PERV-A resistant cells, human and rat PARs, but not muPAR, conferred PERV-A sensitivity. Exogenously expressed ratPAR binds PERV-A Env and allows PERV-A infection with equivalent efficiency to that of huPAR-1. Endogenous ratPAR expression in rat cell lines appeared to be too low for PERV-A infection. In contrast, the presence of Pro at position 109 in muPAR was identified to be the determinant for PERV-A resistance. Pro109. was shown to be located in the second extracellular loop (ECL2) and affected PERV-A Env binding to PAR molecules.
Conclusion: The basis of resistance to PERV-A infection in two rodent species is different. Identification of a single a. a. mutation in muPAR, which is responsible for mouse cell resistance to PERV-A highlighted the importance of ECL-2 for the viral receptor function
OAO/ISLE Near-IR Spectroscopy of IRAS Galaxies
We present the results of the near-infrared (IR) spectroscopy of nine IRAS
galaxies (NGC 1266, NGC 1320, NGC 2633, NGC 2903, NGC 3034, Mrk 33, NGC 7331,
NGC 7625, NGC 7714) with the ISLE imager and spectrograph mounted on the
Okayama Astrophysical Observatory 1.88 m telescope. [Fe II] 1.257 um and Pa
beta emission lines were observed for the whole sample while H2 2.121 um and Br
gamma lines were additionally obtained for two sources, whose flux ratios are
used as a diagnostic tool of dominant energy sources of the galaxies. We find
that the nucleus of NGC 1266 is most likely a low ionization nuclear
emission-line region (LINER), while NGC 2633 and NGC 2903 possibly harbor
active galactic nuclei (AGNs). No AGN or LINER signal is found for other
objects. In addition, we find the spectral features which is indicative of some
unusual phenomena occurring in the galaxies, such as the large [Fe II] line
widths compared to the local escape velocity in NGC 1266. The present work
shows the potential ability of the ISLE to shed new light on the nature of
infrared galaxies, either through a statistical survey of galaxies or an
exploration of spectral features found in individual objects.Comment: Accepted for publication in PAS
CP,T and/or CPT Violations in the K0-K0bar System --Implications of the KTeV,NA48 and CPLEAR Results
Possible violation of CP, T and/or CPT symmetries in the \ko-\kob system
is studied from a phenomenological point of view. For this purpose, we first
introduce parameters which represent violation of these symmetries in mixing
parameters and decay amplitudes in a convenient and well-defined way and,
treating these parameters as small, derive formulas which relate them to the
experimentally measured quantities. We then perform numerical analyses, with
the aid of the Bell-Steinberger relation, to derive constraints to these
symmetry-violating parameters, firstly paying particular attention to the
results reported by KTeV Collaboration and NA48 Collaboration, and then with
the results reported by CPLEAR Collaboration as well taken into account. A case
study, in which either CPT symmetry or T symmetry is assumed, is also carried
out. It is demonstrated that CP and T symmetries are violated definitively at
the level of 10^{-4} in decays and presumably at the level of 10^{-3} in
the \ko-\kob mixing, and that the Bell-Steinberger relation helps us to
establish CP and T violations being definitively present in the \ko-\kob
mixing and to test CPT symmetry to a level of 10^{-4} ~ 10^{-5}.Comment: 21 pages, 1 figure
Explicit solutions for relativistic acceleration and rotation
The Lorentz transformations are represented by Einstein velocity addition on
the ball of relativistically admissible velocities. This representation is by
projective maps. The Lie algebra of this representation defines the
relativistic dynamic equation. If we introduce a new dynamic variable, called
symmetric velocity, the above representation becomes a representation by
conformal, instead of projective maps. In this variable, the relativistic
dynamic equation for systems with an invariant plane, becomes a non-linear
analytic equation in one complex variable. We obtain explicit solutions for the
motion of a charge in uniform, mutually perpendicular electric and magnetic
fields. By assuming the Clock Hypothesis and using these solutions, we are able
to describe the space-time transformations between two uniformly accelerated
and rotating systems.Comment: 15 pages 1 figur
Strategic vs Non-Strategic Motivations of Sanctioning
We isolate strategic and non-strategic motivations of sanctioning in a repeated public goods game. In two experimental treatments, subjects play the public goods game with the possibility to sanction others. In the STANDARD sanctions treatment, each subject learns about the sanctions received in the same round as they were assigned, but in the SECRET sanctions treatment, sanctions are announced only after the experiment is finished, removing in this way all strategic reasons to punish. We find that sanctioning is similar in both treatments, giving support for nonstrategic explanations of sanctions (altruistic punishment). Interestingly, contributions to the public good in both treatments with sanctioning are higher than when the public goods game is played without any sanctioning, irrespective of announcing the sanctions to their receivers during the play of the game, or only after the game is finished. The mere knowledge that sanctions might be assigned increases cooperation: subjects correctly expect that nonstrategic sanctioning takes place against freeriders.altruistic punishment;nonstrategic sanctions;strategic sanctions;public goods;economic experiment
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