Wave energy device and breakwater integration: A review

One of the most abundant energy sources exists in this world is the ocean wave energy. By far, it has shown to be the most clean, renewable, predicted energy and has raised the potential to compete with the current use of non-renewable energy sources. Recent research conducted on wave energy invention has opened a new dimension to slowly reduce the dependency on fossil fuel by introducing new technology on the renewable world but relatively lacking in economical aspect. This review brings the latest status on integration of wave energy device with other marine facilities, which is the breakwater structure that may possibly aid to cost sharing. Most researches done on this field highlighted countries experiencing rough sea condition and focused less on countries with medium wave condition as faced by the Asian continent. The potential for energy extraction and wave dissipation for medium wave condition will be discussed in this review by considering several aspects including reliability, effectiveness and performance. Finally, this review shows that the integration opens up a new dimension to acknowledge the technology harnessing ocean wave, especially for the Asian countries experiencing medium wave condition

Border formation in a Bmp gradient reduced to single dissociated cells

Conversions of signaling gradients into sharp “all-or-none” borders are fundamental to tissue and organismal development. However, whether such conversions can be meaningfully reduced to dissociated cells in culture has been uncertain. Here we describe ultrasensitivity, the phenomenon equivalent to an all-or-none response, in dissociated neural precursor cells (NPCs) exposed to bone morphogenetic protein 4 (Bmp4). NPC ultrasensitivity is evident at the population and single-cell levels based on Msx1 induction, a well known Bmp target response, and occurs in the context of gene expression changes consistent with Bmp4 activity as a morphogen. Dissociated NPCs also display immediate early kinetics and irreversibility for Msx1 induction after brief Bmp4 exposure, which are attractive features for initial border formation. Relevance to border formation in vivo is provided by Bmp4 gain-of-function studies in explants and evidence for single-cell ultrasensitivity in normal and mutant Bmp gradient contexts in the developing forebrain. Together, these studies demonstrate relatively simple, robust, and reducible cell-intrinsic properties that contribute to developmental border formation within a signaling gradient