The coupling of a hearing aid loudspeaker membrane to visco-thermal air layers

Hearing aids and their components are becoming smaller. This presents new problems for the acoustical components, such as the loudspeaker. A circular membrane of a hearing aid loudspeaker is modeled in this paper. Neglecting air influences, the membrane and its suspension behave as a mass spring system. However, under operating conditions, thin layers of air on both sides of the membrane influence its behavior. Air can enter and leave these layers at certain locations on the circular edge of the layer. Since these air layers are thin, visco-thermal effects may have to be taken into account. Therefore, the air layers are not modeled by the wave equation, but by the low reduced frequency model that takes these visco-thermal effects into account. The equations of this model are solved in a polar coordinate system, using a wave-based method. The other acoustical parts of the hearing aid loudspeaker, and the membrane itself are modeled by simple lumped models. The emphasis in this paper is on the coupling of the viscothermal air layer model to the mechanical model of the membrane. Coupling of the air layer to other acoustical parts by using an impedance as boundary condition for the layer model, is also described. The resulting model is verified by experiments. The model and the measurements match reasonably well, considering the level of approximation with lumped parts

Silicon micromachined hollow microneedles for transdermal liquid transfer

This paper presents an improved design and fabrication process [ 13 for hollow micro needles with the proper mechanical strength and sharpness to be applied for painless transdermal transfer of liquids. Tests have shown that liquids like blood are drawn into the needle by capillary forces, reducing the need for active pumping. The fabrication method allows different needle shapes like blades and pencils, is robust enough to be applied for largerscale production, and enables the development of a complete micro-TAS for e.g. blood analysis

A new topological aspect of the arbitrary dimensional topological defects

We present a new generalized topological current in terms of the order parameter field $\vec \phi$ to describe the arbitrary dimensional topological defects. By virtue of the $$-mapping method, we show that the topological defects are generated from the zero points of the order parameter field $\vec \phi$, and the topological charges of these topological defects are topological quantized in terms of the Hopf indices and Brouwer degrees of $\phi$-mapping under the condition that the Jacobian $$. When $J(\frac \phi v)=0$, it is shown that there exist the crucial case of branch process. Based on the implicit function theorem and the Taylor expansion, we detail the bifurcation of generalized topological current and find different directions of the bifurcation. The arbitrary dimensional topological defects are found splitting or merging at the degenerate point of field function $\vec \phi$ but the total charge of the topological defects is still unchanged.Comment: 24 pages, 10 figures, Revte

Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography

Progression of retinal degeneration in a mouse model was studied in vivo with high-resolution spectral-domain optical coherence tomography (SD-OCT). Imaging in 3D with high depth resolution (<3 mu m), SD-OCT resolved all the major layers of the retina of control C57BL/6J mice. Images of transgenic mice having a null mutation of the rhodopsin gene revealed the anatomical consequences of retinal degeneration: thinning of the outer retina, including the outer plexiform layer (OPL), outer nuclear layer (ONL), and inner and outer segments (IS/OS). We monitored the progression of retinal degeneration in rd1 mice (C3H/HeJ) by periodically imaging the same mice from the time the pups opened their eyes on P13 to P34. SD-OCT images showed that the outer retina (OPL, ONL, IS/OS) had already thinned by 73% (100 to 27 mu m) at eye opening. The retina continued to degenerate, and by P20 the outer retina was not resolvable. The thickness of entire retina decreased from 228 mu m (control) to 152 mu m on P13 and to 98 mu m by P34, a 57% reduction with the complete loss in the outer retina. In summary, we show that SD-OCT can monitor the progression of retinal degeneration in transgenic mice.X114367sciescopu

Hamilton-Jacobi Counterterms for Einstein-Gauss-Bonnet Gravity

The on-shell gravitational action and the boundary stress tensor are essential ingredients in the study of black hole thermodynamics. We employ the Hamilton-Jacobi method to calculate the boundary counterterms necessary to remove the divergences and allow the study of the thermodynamics of Einstein-Gauss-Bonnet black holes.Comment: 21 pages, LaTe

Course of uncomplicated acute gastroenteritis in children presenting to out-of-hours primary care

Background The aim of this article is to describe the courses of vomiting, diarrhea, fever, and clinical deterioration, in children with uncomplicated gastroenteritis at presentation. This study was performed as a 7-day prospective follow-up study in an out-of-hours primary care service. The course of vomiting, diarrhea, and fever was analyzed by generalized linear mixed modeling. Because young children ( 90%). Vomiting and fever decreased rapidly, but diarrhea decreased at a somewhat slower pace, especially among children aged 6-12 months. Children who deteriorated during follow-up had a higher frequency of vomiting at presentation and higher frequencies of vomiting and fever during follow-up. Conclusions The frequency of vomiting, not its duration, appears to be the more important predictor of deterioration. When advising parents, it is important to explain the typical symptom duration and to focus on alarm symptoms. Clinicians should be vigilant for children with higher vomiting frequencies at presentation and during follow-up because these children are more likely to deteriorate