19 research outputs found
Indo-western Pacific ocean capacitor and coherent climate anomalies in post-ENSO summer: A review
Impact of tropical and subtropical SSTs on mid-latitude tropospheric warming in the northern summer of 2010
Studies on Neurosteroids XXV. Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism
A possible cause of the AO polarity reversal from winter to summer in 2010 and its relation to hemispheric extreme summer weather
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors
The diagnostic ability of SPECT/CT fusion imaging for gastrointestinal bleeding: a retrospective study
The predictive value of preoperative 18F-fluorodeoxyglucose PET for postoperative recurrence in patients with localized primary gastrointestinal stromal tumour
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)
Antônio Talvane Torres de Oliveira and Céline Pinheiro contributed
equally to the studyProva tipográfica (uncorrected proof)Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher’s Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient’s overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.This study was supported by CNPq – Conselho Nacional de Desenvolvimento Científico e Tecnológico (Grant number: 476936/2008-0). CP and OM received fellowships from the Portuguese Science and Technology Foundation (ref. SFRH/BPD/69479/2010 and SFRH/BD/36463/2007, respectively)