Review of presentations at the 6th European Lupus Meeting 3-5 March 2005.

The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new developments in both clinical and basic science aspects of systemic lupus erythematosus. This review summarizes the major points covered in each session

An ant colony optimization approach for maximizing the lifetime of heterogeneous wireless sensor networks

Maximizing the lifetime of wireless sensor networks (WSNs) is a challenging problem. Although some methods exist to address the problem in homogeneous WSNs, research on this problem in heterogeneous WSNs have progressed at a slow pace. Inspired by the promising performance of ant colony optimization (ACO) to solve combinatorial problems, this paper proposes an ACO-based approach that can maximize the lifetime of heterogeneous WSNs. The methodology is based on finding the maximum number of disjoint connected covers that satisfy both sensing coverage and network connectivity. A construction graph is designed with each vertex denoting the assignment of a device in a subset. Based on pheromone and heuristic information, the ants seek an optimal path on the construction graph to maximize the number of connected covers. The pheromone serves as a metaphor for the search experiences in building connected covers. The heuristic information is used to reflect the desirability of device assignments. A local search procedure is designed to further improve the search efficiency. The proposed approach has been applied to a variety of heterogeneous WSNs. The results show that the approach is effective and efficient in finding high-quality solutions for maximizing the lifetime of heterogeneous WSNs

An efficient ant colony system based on receding horizon control for the aircraft arrival sequencing and scheduling problem

The aircraft arrival sequencing and scheduling (ASS) problem is a salient problem in air traffic control (ATC), which proves to be nondeterministic polynomial (NP) hard. This paper formulates the ASS problem in the form of a permutation problem and proposes a new solution framework that makes the first attempt at using an ant colony system (ACS) algorithm based on the receding horizon control (RHC) to solve it. The resultant RHC-improved ACS algorithm for the ASS problem (termed the RHC-ACS-ASS algorithm) is robust, effective, and efficient, not only due to that the ACS algorithm has a strong global search ability and has been proven to be suitable for these kinds of NP-hard problems but also due to that the RHC technique can divide the problem with receding time windows to reduce the computational burden and enhance the solution's quality. The RHC-ACS-ASS algorithm is extensively tested on the cases from the literatures and the cases randomly generated. Comprehensive investigations are also made for the evaluation of the influences of ACS and RHC parameters on the performance of the algorithm. Moreover, the proposed algorithm is further enhanced by using a two-opt exchange heuristic local search. Experimental results verify that the proposed RHC-ACS-ASS algorithm generally outperforms ordinary ACS without using the RHC technique and genetic algorithms (GAs) in solving the ASS problems and offers high robustness, effectiveness, and efficienc

Differential effects of epigallocatechin gallate on cigarette smoke-induced upregulation of CINC-1 and IL-6 in Rat H9c2 cardiomyocytes

INTRODUCTION: Cigarette smoke (CS) containing numerous harmful substances is considered to precipitate spasm of micro vessels, which is supported as a cause of idiopathic-dilated cardiomyopathy, as well as have a toxic effect on the myocardium. The mechanism is currently unclear, but both oxidative stress and inflammatory responses may play an essential role in the CS-induced biological processes. Several antioxidant agents have been used in the control of the inflammatory responses. The aim of this study was to investigate the effect of epigallocatechin gallate (EGCG), the major component of polyphenols in green tea, on CS-induced inflammatory responses in rat H9c2 cardiomyocyte …published_or_final_versio

The emerging role of autophagy in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder that affects about 1% of the population worldwide. Despite significant advances in the identification of genetic mutations and signaling pathways that are associated with the disease, the precise mechanisms implicated in the pathophysiology of the disease are not well understood. More importantly, treatments that are effective in reversing the progression of the disease is essentially lacking. Further investigation into the pathogenic mechanisms of PD thus presents a pressing concern for neuroscientists. Recently, deregulation of the autophagic pathway is observed in the brains of PD patients and in models of PD. In this review we summarize current literature on the emerging involvement of autophagy in PD, and the implication for future development of treatment against the disorder

Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

SummaryStem cell division is essential for tissue integrity during growth, aging, and pathogenic assaults. Adult gastrointestinal tract encounters numerous stimulations, and impaired tissue regeneration may lead to inflammatory diseases and cancer. Intestinal stem cells in adult Drosophila have recently been identified and shown to replenish the various cell types within the midgut. However, it is not known whether these intestinal stem cells can respond to environmental challenges. By feeding dextran sulfate sodium and bleomycin to flies and by expressing apoptotic proteins, we show that Drosophila intestinal stem cells can increase the rate of division in response to tissue damage. Moreover, if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells. By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division

Particle acceleration and the origin of gamma-ray emission from Fermi Bubbles

Fermi LAT has discovered two extended gamma-ray bubbles above and below the galactic plane. We propose that their origin is due to the energy release in the Galactic center (GC) as a result of quasi-periodic star accretion onto the central black hole. Shocks generated by these processes propagate into the Galactic halo and accelerate particles there. We show that electrons accelerated up to ~10 TeV may be responsible for the observed gamma-ray emission of the bubbles as a result of inverse Compton (IC) scattering on the relic photons. We also suggest that the Bubble could generate the flux of CR protons at energies > 10^15 eV because the shocks in the Bubble have much larger length scales and longer lifetimes in comparison with those in SNRs. This may explain the the CR spectrum above the knee.Comment: 5 pages, 4 figures. Expanded version of the contribution to the 32nd ICRC, Beijing, #0589. To appear in the proceeding

Necrotizing Fasciitis of the Extremity Caused by Haemophilus influenzae Serotype b in a Healthy Adult

Haemophilus influenzae is a rare cause of necrotizing fasciitis with only a few previously reported cases. We describe the case of a 44-year-old man who had necrotizing fasciitis of the right lower extremity develop after intramuscular injections of paracetamol on his right buttock. The causative organism isolated was Haemophilus influenzae serotype b. This unusual infection was treated with repeated débridement and culture-guided antibiotics. There was no recurrence of infection at last followup 1 year after the initial surgery. Wound coverage was achieved with the use of a full-thickness skin graft after application of platelet-rich plasma and a dermal regeneration template. This resulted in a cosmetically acceptable appearance of the involved extremity for our patient