Subcutaneous C.E.R.A. for the Treatment of Chronic Renal Anemia in Predialysis Patients

Background: We investigated the efficacy, safety and tolerability of once-monthly administration of C.E.R.A. in erythropoiesis stimulating agents (ESAs) naive predialysis patients with CKD for anemia treatment Study Design: Single arm, open label study. Methods: A total of 75 patients (mean (SD) age was 52.8 (16.4) years, 76.0% were female) were included in this study conducted between 12 August 2008 and 30 October 2009 in 9 centers across Turkey. The mean change in Hb concentration (g/dL) between baseline (week 0) and the efficacy evaluation period (EEP) was the primary efficacy parameter evaluated in three consecutive periods including a dose titration period (DTP; with initial 1.2 ?g/kg dose of C.E.R.A., subcutaneously, 28 weeks), EEP (8 weeks) and a long-term safety period (16 weeks). Results: Our analysis revealed an improvement in Hb levels from baseline value of 9.4 (0.4) g/dL to time adjusted average level of 11.4 (0.7) g/dL in EEP in the per protocol (PP) population and from 9.3 (0.5) g/dL to 11.1 (1.0) g/dL in intent-to-treat (ITT) population. Mean (SD) change in Hb levels from baseline to EEP was 2.0 (0.7) g/dl in the PP population (primary endpoint) and 1.7 (1.1) g/dL in the ITT population. The percentage of patients whose Hb concentrations remained within the target range of 10.0-12.0 g/dL throughout the EEP was 43.9% (95% CI: 28.5-60.3%) in the PP population and 38.7% (95% CI: 27.6% to 50.6%) in the ITP population. A total of 206 adverse events (AE) were reported in 77.0% of patients with hypertension (20%) as the most frequent AE. Conclusion: Once-monthly subcutaneous C.E.R.A. administration is effective and safe in the treatment of anemia in pre-dialysis patients with CKD, who are not currently treated with ESAs

An analytical investigatıon on starlikeness and convexity properties for hypergeometric functions

In this study, we analytically investigate hypergeometric functions having some properties such as convexityand starlike. We fundamentally focus on obtaining desired conditions on the parameters a, b , and c in order that ahypergeometric function to be in various subclasses of starlike and convex functions of order $\alpha\;=\;2^{-r}$and order $\alpha\;=\;2^{-r}$type $\beta\;=\;2^{-1}$, with r is a positive integer.WOS:0005483791000272-s2.0-8508939290

Convex and Starlike Functions Defined on the Subclass of the Class of the Univalent Functions S with Order 2(- r)

In this paper, some conditions have been improved so that the function g(z) is defined as g(z) = 1+ Sigma(infinity)(k >= 2) alpha n+k(zn+k), which is analytic in unit disk U, can be in more specific subclasses of the S class, which is the most fundamental type of univalent function. It is analyzed some characteristics of starlike and convex functions of order 2(-r)

ON SUFFICIENT CONDITIONS FOR CLOSE-TO-CONVEXITY OF ORDER 2(-r)

WOS: 000454272000008The main idea of the present paper is to obtain sufficient conditions for close-to-convexity of order in 2(-r), where r is a positive integer

AN INVESTIGATION ON GEOMETRIC PROPERTIES OF ANALYTIC FUNCTIONS WITH POSITIVE AND NEGATIVE COEFFICIENTS EXPRESSED BY HYPERGEOMETRIC FUNCTIONS

This paper aims to investigate characterizations on parameters k(1), k(2), k(3), k(4), k(5), l(1), l(2), l(3), and l(4) to find relation between the class of H(k, l, m, n, o) hypergeometric functions defined by F-5(4) [(l1, l2, l3, l4) (k1, k2, k3, k4, k5,) : z] = Sigma(infinity)(n=2) (k(1))(n) (k(2))(n) (k(3))(n) (k(4))(n) (k(5))(n)/(l(1))(n) (l(2))(n) (l(3))(n) (l(4))(n) (1)(n) z(n). We need to find k, l, m and n that lead to the necessary and sufficient condition for the function zF([W]), G = z(2 - F ([W])) and H-1[W] =z(2) d/dz (ln(z) - h(z)) to be in S*(2(-r)), r is a positive integer in the open unit disc D = {z : vertical bar z vertical bar < 1, z is an element of C} with h(z) = Sigma(infinity)(n=0) (k)(n)(l)(n)(m)(n)(n)(n) (1 + k/2)(n)/(k/2)(n)(1 + k - l)(n) (1 + k - m)(n) (1 + k - n)(n)n(1)(n) z(n) and [W] = [(k/2, 1 + k -l, 1 + k - m, 1 + k - n) (k, 1 + k/2, l,) (m, n) :z]

ON SUFFICIENT CONDITION FOR STARLIKENESS OF CONFLUENT HYPERGEOMETRIC FUNCTIONS

WOS: 000454272000007In the present paper, firstly some univalent functions are obtained as special cases of hypergeometric functions and then we have discussed the starlikeness of confluent hypergeometric functions

Effectiveness of ultra-rapid dose titration of clozapine for treatment-resistant bipolar mania: Case series

Treatment of severe and refractory manic episodes in hospital settings can occasionally be very difficult. In particular, severely excited patients showing aggressive, hostile, impulsive behaviours frequently require physical restraint and seclusion, high doses of antipsychotics and benzodiazepines, and sometimes, electroconvulsive therapy. Hospital stay is generally prolonged and such patients cause great emotional distress for other patients in the ward and clinical staff involved in their care. Here we report on three patients with a diagnosis of bipolar disorder and one patient with a diagnosis of schizoaffective disorder bipolar subtype, all of whom were hospitalized for severe manic episodes with psychotic features. These patients were extremely difficult to manage in the ward as no response could be obtained in the first week of treatment despite high doses of antipsychotics and benzodiazepine administration. The introduction and rapid titration of clozapine proved remarkably effective and was well tolerated in the acute management of these patients. We observed that clozapine had a superior and fast mood stabilization effect with rapid titration and could be extremely helpful in the management of such patients