Ortaöğretim Öğrencilerinin Üst Düzey Okuduğunu Anlama Becerilerinin İncelenmesi

Bu çalışmanın amacı, öğrencilerin üst düzey okuduğunu anlama becerilerini farklı değişkenlere göre incelemek ve yanlış cevapların nedenlerini belirlemektir. Karma yönteme dayanan bu araştırma, açımlayıcı desenle gerçekleştirilmiştir. Veriler “Üst Düzey Okuduğunu Anlama Becerileri Başarı Testi” aracılığıyla toplanmıştır. Nicel verilerin analizinde betimsel ve ilişkisel istatistikler, nitel verilerin analizinde doküman incelemesi kullanılmıştır. Araştırmanın katılımcıları amaçlı örnekleme yöntemlerinden ölçüt örnekleme tekniği kullanılarak belirlenen 312 ortaöğretim ikinci sınıf öğrencisidir. Bulgulara göre öğrencilerin başarı testinden aldıkları puanların düşük olduğu; üst düzey okuduğunu anlama becerilerinin, cinsiyet değişkenine göre anlamlı farklılık göstermediği; ders notları ile üst düzey okuduğunu anlama başarı puanları arasında pozitif yönde ve düşük düzeyde ilişkiler bulunduğu; internette ve bilişsel oyunlarda nispeten fazla vakit geçirenlerin üst düzey okuduğunu anlama becerilerinin daha yüksek olduğu belirlenmiştir. Öğrencilerin cevapları analiz edildiğinde sorunun çözümüne ulaşabilmeleri için çıkarımda bulunmalarını sağlayacak karşılaştırmalar yapma, analiz etme ve yorumlayabilme becerilerini kullanamadıkları; yanlış cevaplar verdikleri soruların büyük oranda süreksiz metinleri içeren sorular olduğu belirlenmiştir

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming

Epigenetic reprogramming to pluripotency requires extensive remodeling of chromatin landscapes to silence existing cell-type-specific genes and activate pluripotency genes. ATP-dependent chromatin remodeling complexes are important regulators of chromatin structure and gene expression; however, the role of recently identified Bromodomain-containing protein 9 (BRD9) and the associated non-canonical BRG1-associated factors (ncBAF) complex in reprogramming remains unknown. Here, we show that genetic or chemical inhibition of BRD9, as well as ncBAF complex subunit GLTSCR1, but not the closely related BRD7, increase human somatic cell reprogramming efficiency and can replace KLF4 and c-MYC. We find that BRD9 is dispensable for human induced pluripotent stem cells under primed but not under naive conditions. Mechanistically, BRD9 inhibition downregulates fibroblast-related genes and decreases chromatin accessibility at somatic enhancers. BRD9 maintains the expression of transcriptional regulators MN1 and ZBTB38, both of which impede reprogramming. Collectively, these results establish BRD9 as an important safeguarding factor for somatic cell identity whose inhibition lowers chromatin-based barriers to reprogramming

Membranous nephropathy in Turkey: Turkish society of nephrology glomeruler diseases (TSN-Gold) database results

...ERA EDT

Clinical and pathologic features of primary membranous nephropathy in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

Background: We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods: This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results: A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m2 (IQR, 75.4–116.3), and median proteinuria was 6000 mg/d (IQR, 3656–9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions: Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people

The effect of COVID-19 on development of hair and nail disorders: a Turkish multicenter, controlled study

© 2022 the International Society of Dermatology.Background: A broad spectrum of skin diseases, including hair and nails, can be directly or indirectly triggered by COVID-19. It is aimed to examine the type and frequency of hair and nail disorders after COVID-19 infection. Methods: This is a multicenter study conducted on consecutive 2171 post-COVID-19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined. Results: The rate of the previous admission in hospital due to COVID-19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID-19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID-19 infection. The mean stress scores during and after getting infected with COVID-19 were 6.88 ± 2.77 and 3.64 ± 3.04, respectively, in the hair loss group and were 5.77 ± 3.18 and 2.81 ± 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID-19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4–7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222–7.027]). The most common nail disorders were leukonychia, onycholysis, Beau's lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID-19 were statistically significantly more common in patients having nail disorders after getting infected with COVID-19 when compared to the control group (P < 0.05). Conclusion: The development of both nail and hair disorders after COVID-19 seems to be related to a history of severe COVID-19