Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury

Voltage-gated sodium channels play important roles in modulating dorsal root ganglion (DRG) neuron hyperexcitability and hyperalgesia after peripheral nerve injury or inflammation. We report that chronic compression of DRG (CCD) produces profound effect on tetrodotoxin-resistant (TTX-R) and tetrodotoxin-sensitive (TTX-S) sodium currents, which are different from that by chronic constriction injury (CCI) of the sciatic nerve in small DRG neurons. Whole cell patch-clamp recordings were obtained in vitro from L4 and/or L5 dissociated, small DRG neurons following in vivo DRG compression or nerve injury. The small DRG neurons were classified into slow and fast subtype neurons based on expression of the slow-inactivating TTX-R and fast-inactivating TTX-S Na+ currents. CCD treatment significantly reduced TTX-R and TTX-S current densities in the slow and fast neurons, but CCI selectively reduced the TTX-R and TTX-S current densities in the slow neurons. Changes in half-maximal potential (V1/2) and curve slope (k) of steady-state inactivation of Na+ currents were different in the slow and fast neurons after CCD and CCI treatment. The window current of TTX-R and TTX-S currents in fast neurons were enlarged by CCD and CCI, while only that of TTX-S currents in slow neurons was increased by CCI. The decay rate of TTX-S and both TTX-R and TTX-S currents in fast neurons were reduced by CCD and CCI, respectively. These findings provide a possible sodium channel mechanism underlying CCD-induced DRG neuron hyperexcitability and hyperalgesia and demonstrate a differential effect in the Na+ currents of small DRG neurons after somata compression and peripheral nerve injury. This study also points to a complexity of hyperexcitability mechanisms contributing to CCD and CCI hyperexcitability in small DRG neurons

Remote Sensing of Mangrove Wetlands Identification

AbstractMangrove wetland has become the important and hot object for wetland research in recent years. Because remote sensing technique has applied gradually to the survey of mangrove resources, there is important realistic and theoretical significance for the remote sensing identification research of mangrove. This paper introduces the source of data of the mangrove remote sensing recognition technology processing, classification method and feature extraction.We also analyze the existings weakness, finally we put forward some related suggestions and forecast the future

Anomalous pressure behavior of tangential modes in single-wall carbon nanotubes

Using the molecular dynamics simulations and the force constant model we have studied the Raman-active tangential modes (TMs) of a (10, 0) single-wall carbon nanotube (SWNT) under hydrostatic pressure. With increasing pressure, the atomic motions in the three TMs present obvious diversities. The pressure derivative of E1g, A1g, and E2g mode frequency shows an increased value (), a constant value (), and a negative value () above 5.3 GPa, respectively. The intrinsic characteristics of TMs consumedly help to understand the essence of the experimental T band of CNT. The anomalous pressure behavior of the TMs frequencies may be originated from the tube symmetry alteration from D10h to D2h then to C2h.Comment: 15 pages, 3 pages, submitted to Phys. Rev.

Limits to sustained energy intake. XXX : Constraint or restraint? Manipulations of food supply show peak food intake in lactation is constrained

This work was partly supported by grants (No. 31670417, 31870388) from the National Natural Science Foundation of China and the Chinese Academy of Sciences Strategic program (XDB13030100). All data is available in the main text or the supplementary materials. Additional data related to this paper may be requested from the authors. Requests should be addressed to Z.J.Z. and J.R.SPeer reviewedPublisher PD

Well-Posedness by Perturbations for Variational-Hemivariational Inequalities

We generalize the concept of well-posedness by perturbations for optimization problem to a class of variational-hemivariational inequalities. We establish some metric characterizations of the well-posedness by perturbations for the variational-hemivariational inequality and prove their equivalence between the well-posedness by perturbations for the variational-hemivariational inequality and the well-posedness by perturbations for the corresponding inclusion problem