Numerical Simulation Analysis of Water Injection Seepage Law in Micro Porous Structure of Coal

In this paper, a nano Voxel X-ray 3D microscope is used to scan the long flame coal samples and to reconstruct the 3D pore structure by the use of microscopic computed tomography. With image segmentation technique, a model of micro-pore structure of coal is obtained from the reconstructed coal. With different planes selected as seepage inlets, a numerical simulation of low-pressure water seepage is conducted. Studies show that water pressure gradually decreases along the direction of water seepage and reaches the maximum at the pore-pipes with good connectivity near the inlet. Due to the difference between the structure and development direction of pores in the three dimensions, there is an optimal seepage outlet that is most appropriately corresponding to each seepage inlet. When different planes are selected as seepage inlets, the velocity of each seepage outlet is positively correlated with the seepage mass flow rate at the outlet

Development and construction of China

Libraries in China's higher education institutions have been developing in keeping pace with the flourishing development of China's higher education. This article aims to make an introduction to the construction of China's higher education libraries, especially the recent three decades' achievements since China's reform and opening-up in 1978. In this article, the authors draw a general picture of the development of libraries in China's higher education institutions, covering such eight aspects as management, types and positioning, organizational structure and personnel, expenditure and buildings, reader service, building and sharing of resources as well as automation system.</p

Research on the role of SOX9 in regulating metabolic reprogramming in diffuse large B cell lymphoma

Objective·To explore the role played by the differentially expressed SRY-box transcription factor 9 (SOX9) gene in diffuse large B cell lymphoma (DLBCL), particularly in the regulation of metabolic reprogramming in the germinal center B-cell (GCB) like subtype.Methods·The clinical information and gene expression profile data of 481 DLBCL patients retrieved from the NCICCR-DLBCL database were included. Data analysis and visualisation were performed by using R language version 4.1.3. The classification was performed by using a cell of origin subtype (COO) classification algorithm based on RNA-seq sequencing of expression. ABC/GCB features were used to annotate gene sets, and the classification was verified by gene set enrichment analysis. The ABC and GCB subgroup was dichotomised based on the mean expression of SOX9. Differential analysis was performed by using the DEseq2 package. The relationship between SOX9 and ABC-DLBCL metabolism was analysed by using KEGG (Kyoto Encyclopedia of Genes and Genomes) with the Hallmark annotation set. The survival curves were plotted by using the Kaplan-Meier method. The pan-cancer analysis was performed by using GEPIA2. The microenvironmental scoring analysis was performed by the ESTIMATE package.Results·Of the 481 DLBCL patient samples, all the patients had RNA-seq expression data, 421 had clinical staging, 335 had international prognostic index (IPI) scores and 234 had survival data. The classification yielded 232 (48.2%) ABC subtypes, 173 (36.0%) GCB subtypes and 76 (15.8%) unclassified, consistent with the proportions declared in the database, and the enrichment analysis was verified to be consistent with the ABC/GCB expression profile. Compared to the high SOX9 expression group, the overall survival was shorter in the low SOX9 expression group and the prognostic score was worse. The pan-cancer analysis showed that this phenomenon was also seen in other tumor types. The differential analysis showed that there were 156 upregulated genes and 1 826 downregulated genes in the GCB subtype in the low SOX9 expression group, compared to the high SOX9 expression group. For metabolic processes, down-regulated genes were enriched in glycolysis.Conclusion·In the ABC subtype of DLBCL, the SOX9 gene affects the biological features of ABC-DLBCL by regulating metabolic reprogramming, and low expression of SOX9 in DLBCL, possibly caused by high methylation, predicts decreased glycolysis in tumors. The proportion of tumor stromal cells decreases, showing a worse prognosis

Design Methodology for Six-Port Equal/Unequal Quadrature and Rat-Race Couplers With Balanced and Unbalanced Ports Terminated by Arbitrary Resistances

For the first time, the 6-port quadrature and rat-race couplers with balanced-unbalanced-hybrid ports are proposed. The corresponding design methodology is presented, which is capable of designing the proposed couplers with arbitrary power divisions and terminated resistances. In this paper, four types including quadrature and rat-race couplers are fully analyzed, covering all the application configurations of the balanced/unbalanced ports. Besides, the design equations are rigorously derived, with the final design procedures presented. Eventually, prototypes of the four coupler types are fabricated and experimentally measured. The final results sufficiently validate the proposed methodology

Photoproduction of the charged top-pions at the LHeC

The top triangle moose $(TTM)$ model, which can be seen as the deconstructed version of the topcolor-assisted technicolor ($TC2$) model, predicts the existence of the charged top-pions $\pi_{t}^{\pm}$ in low energy spectrum. In the context of this model, we consider photoproduction of $\pi^{\pm}_{t}$ via the subprocesses $\gamma b\to t \pi_{t}^{-}$ and $\gamma \bar{b}\to \bar{t} \pi_{t}^{+}$ at the large hadron-electron collider ($LHeC$), in which high energy photon beams are generated by using the Compton backscatting method. We find that, as long as the charged top-pions are not too heavy, they can be abundantly produced via $\gamma b$ collision.Comment: 16 pages, 5 figure

Transduced PEP-1-Heme Oxygenase-1 Fusion Protein Attenuates Lung Injury in Septic Shock Rats

Oxidative stress and inflammation have been identified to play a vital role in the pathogenesis of lung injury induced by septic shock. Heme oxygenase-1 (HO-1), an effective antioxidant and anti-inflammatory and antiapoptotic substance, has been used for the treatment of heart, lung, and liver diseases. Thus, we postulated that administration of exogenous HO-1 protein transduced by cell-penetrating peptide PEP-1 has a protective role against septic shock-induced lung injury. Septic shock produced by cecal ligation and puncture caused severe lung damage, manifested in the increase in the lung wet/dry ratio, oxidative stress, inflammation, and apoptosis. However, these changes were reversed by treatment with the PEP-1-HO-1 fusion protein, whereas lung injury in septic shock rats was alleviated. Furthermore, the septic shock upregulated the expression of Toll-like receptor 4 (TLR4) and transcription factor NF-κB, accompanied by the increase of lung injury. Administration of PEP-1-HO-1 fusion protein reversed septic shock-induced lung injury by downregulating the expression of TLR4 and NF-κB. Our study indicates that treatment with HO-1 protein transduced by PEP-1 confers protection against septic shock-induced lung injury by its antioxidant, anti-inflammatory, and antiapoptotic effects