Millennial-scale variations in sedimentary oxygenation in the western subtropical North Pacific and its links to North Atlantic climate

The deep-ocean carbon cycle, especially carbon sequestration and outgassing, is one of the mechanisms to explain variations in atmospheric CO2 concentrations on millennial and orbital timescales. However, the potential role of subtropical North Pacific subsurface waters in modulating atmospheric CO2 levels on millennial timescales is poorly constrained. An increase in the respired CO2 concentration in the glacial deep-ocean due to biological pump generally corresponds to deoxygenation in the ocean interior. This link thus offers a chance to study oceanic ventilation and coeval export productivity based on redox-controlled sedimentary geochemical parameters. Here, we investigate a suite of geochemical proxies in a sediment core from the Okinawa Trough to understand sedimentary oxygenation variations in the subtropical North Pacific over the last 50 000 years (50 ka). Our results suggest that enhanced mid-depth western subtropical North Pacific (WSTNP) sedimentary oxygenation occurred during cold intervals and after 8.5 ka, while oxygenation decreased during the Bölling-Alleröd (B/A) and Preboreal. The enhanced oxygenation during cold spells is linked to the North Pacific IntermediateWater (NPIW), while interglacial increase after 8.5 ka is linked to an intensification of the Kuroshio Current due to strengthened northeast tradewinds over the tropics. The enhanced formation of the NPIW during Heinrich Stadial 1 (HS1) was likely driven by the perturbation of sea ice formation and sea surface salinity oscillations in the high-latitude North Pacific. The diminished sedimentary oxygenation during the B/A due to a decreased NPIW formation and enhanced export production, indicates an expansion of the oxygen minimum zone in the North Pacific and enhanced CO2 sequestration at mid-depth waters, along with the termination of atmospheric CO2 concentration increase. We attribute the millennial-scale changes to an intensified NPIW and enhanced abyss flushing during deglacial cold and warm intervals, respectively, closely related to variations in North Atlantic Deep Water formation

Health-related quality of life and its association with socioeconomic status and diet diversity in Chinese older adults

ObjectivesThe study aimed at examining the combined association of socioeconomic status (SES) and diet diversity (DD) with health-related quality of life (HRQoL) and exploring whether DD played a mediating role in the relationship between varied SES and HRQoL among Chinese older persons.MethodA multi-stage random sampling method was conducted in Shanxi Province of China, with 3,250 older adults participating in this cross-sectional survey. SES was divided into groups by quartiles and DD by means, and these variable groups were combined in pairs to generate a total of eight combinations. The PROCESS macro developed by Hayes was employed for the simple mediation analysis.ResultsCompared with the reference group (those with both high SES and high DD), older adults who were classified to have lower SES or DD had elevated odds of having worse HRQoL: low SES/ low DD (OR = 1.65, 95% CI 1.41–2.92); low SES/ high DD (OR = 1.45, 95% CI 1.17–1.80); middle low SES/ low DD (OR = 1.43, 95% CI 1.24–1.65); middle low SES/ high DD (OR = 1.23, 95% CI 1.03–1.47); upper high SES/ low DD (OR = 1.41, 95% CI 1.21–1.65); and high SES/ low DD (OR = 1.30, 95%CI 1.10–1.53). The mediation analysis revealed that DD mediated the relationship between SES and HRQoL (B=0.011, 95% CI 0.008–0.013), with its indirect effects accounting for 39.29% of the total effects.ConclusionsThese findings highlighted the role of DD as a mediator of the relationship between SES and HRQoL. As DD could be protective, modifiable, and easy for older adults to understand and implement, village clinics and community health stations should work collaboratively to design proper DD intervention measures for better HRQoL

RNA-seq Analysis of the BCG Vaccine in a Humanized Mouse Model

This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by the Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model. Candidate DEGs between mice vaccinated with BCG or injected with PBS were identified through transcriptomics, and their biological functions, signaling pathways, and protein interaction networks were analyzed through bioinformatics. A total of 1035 DEGs were identified by transcriptomics: 398 up-regulated and 637 down-regulated. GO analysis indicated that these DEGs were significantly enriched in cell adhesion, oxygen transport, receptor complex, carbohydrate binding, serine-type endopeptidase activity, and peroxidase activity terms. KEGG analysis indicated that these DEGs were involved in the Rap1 signaling pathway, axon guidance, PI3K-Akt signaling pathway, natural killer cell mediated cytotoxicity, and cytokine-cytokine receptor interaction. Protein interaction network analysis demonstrated that the Myc, Vegfa, and Itgb3 proteins had the highest aggregation degree, aggregation coefficient, and connectivity. The BCG vaccine induced 1035 DEGs in humanized mice. Among them, the differentially expressed down-regulated genes myc and itgb3 involved in the PI3K-Akt signaling pathway may play essential roles in the immune mechanism of the BCG vaccine

Genome and pan-genome assembly of asparagus bean (Vigna unguiculata ssp. sesquipedialis) reveal the genetic basis of cold adaptation

Asparagus bean (Vigna unguiculata ssp. sesquipedialis) is an important cowpea subspecies. We assembled the genomes of Ningjiang 3 (NJ, 550.31 Mb) and Dubai bean (DB, 564.12 Mb) for comparative genomics analysis. The whole-genome duplication events of DB and NJ occurred at 64.55 and 64.81 Mya, respectively, while the divergence between soybean and Vigna occurred in the Paleogene period. NJ genes underwent positive selection and amplification in response to temperature and abiotic stress. In species-specific gene families, NJ is mainly enriched in response to abiotic stress, while DB is primarily enriched in respiration and photosynthesis. We established the pan-genomes of four accessions (NJ, DB, IT97K-499-35 and Xiabao II) and identified 20,336 (70.5%) core genes present in all the accessions, 6,507 (55.56%) variable genes in two individuals, and 2,004 (6.95%) unique genes. The final pan genome is 616.35 Mb, and the core genome is 399.78 Mb. The variable genes are manifested mainly in stress response functions, ABC transporters, seed storage, and dormancy control. In the pan-genome sequence variation analysis, genes affected by presence/absence variants were enriched in biological processes associated with defense responses, immune system processes, signal transduction, and agronomic traits. The results of the present study provide genetic data that could facilitate efficient asparagus bean genetic improvement, especially in producing cold-adapted asparagus bean

Impact of Grain Subsidy Reform on the Land Use of Smallholder Farms: Evidence from Huang-Huai-Hai Plain in China

Smallholder farms have played an essential role in agricultural production and food security. In order to increase farm size, the Chinese government announced a reform of the grain subsidy program in 2015. Under the reform, 20% of the aggregate input subsidy, as well as the pilot subsidy to large-scale farmers and the incremental part of the agricultural support and protection subsidy budget, were used to support increasing farm size. This study evaluated the impact of China’s grain subsidy reform on the land use of smallholder farms to investigate whether the reform achieved its goal. Based on 2063 samples obtained from the 2013–2015 Survey for Agriculture and Village Economy data in Huang-Huai-Hai Plain, we conducted a difference-in-difference model to solve the problem of missing counterfactual states in policy evaluation. Farms from Henan and Shandong were assigned to the treatment group, and farms from Hebei were assigned to the control group. The results revealed that the average treatment effect on the treated of the impact of the grain subsidy reform on the wheat-sown area was −25% (0.10 ha). Furthermore, there was heterogeneity in regard to the subsidy reform effects in different sown-area groups. The reform had the most significant impact on the smallest farmers. We also found that China’s grain subsidy reform had a significant and positive effect on the amount of outflow land area, while the impact of subsidy reform on land tenure was insignificant. Our findings suggest that while encouraging large-scale farms, it is necessary to take into account farmers’ small-scale operations and gradually promote the transformation of small-scale operations to large-scale operations. The Chinese government should strengthen the supervision of land use to achieve the goal of ensuring food security

Effects of whey protein-polyphenol conjugates incorporation on physicochemical and intelligent pH-sensing properties of carboxymethyl cellulose based films

This study aimed to develop carboxymethyl cellulose films functionalized by whey protein and polyphenols (proanthocyanidins and curcumin) conjugates. The physicochemical properties, freshness monitoring and preservation ability of films with conjugates were evaluated. The results showed that the vapor barrier property, tensile strength and contact angle of films incorporated with conjugates were improved 10%–31%, 61%–134%, 4%–19% respectively. Furthermore, the incorporation of conjugates improved the ability to indicate the changes of pH value, inhibit the microbial growth and prevent fat oxidation, when the films were applied for beef preservation. The improvement was attributed to the enhancement of intermolecular interactions and higher binding rate, which helped to form the films with more compact and uniform microstructure. This study suggested that films containing conjugates can be applied for monitoring freshness and extending the shelf-life of beef

Can Agricultural Machinery Harvesting Services Reduce Cropland Abandonment? Evidence from Rural China

Ending hunger, achieving food security, and promoting sustainable agriculture are the main targets of sustainable development goals. It is well known that cropland resources are the most essential factor in achieving sustainable development goals. However, China has been facing the problem of a continuous reduction in cropland resources. Reducing the abandonment of cropland has become an important way to curb the reduction in cropland resources. Can agricultural machinery harvesting services reduce cropland abandonment in rural China? To answer this scientific question, this study employs the Survey for Agriculture and Village Economy data from 8345 samples of 12 provinces in rural China. The extended regression models (i.e., the extended probit regression model and the extended interval regression model) are used to empirically analyze the relationship between agricultural machinery harvesting services accessed by farmers and cropland abandonment. The results are as follows. Agricultural machinery harvesting services accessed by farmers significantly reduced the probability of cropland abandonment and the proportion of the area of abandoned cropland in farmers’ contracted cropland area decreased by 18.5% and 20.3%, respectively. Moreover, the heterogeneity analysis results showed that farmers’ access to agricultural machinery harvesting services significantly reduced cropland abandonment in small-scale groups, without elderly households, with nonagricultural income groups, and in the eastern region. This study also provides some policy implications for policymakers to reduce cropland abandonment in rural China

Can Agricultural Machinery Harvesting Services Reduce Cropland Abandonment? Evidence from Rural China

Ending hunger, achieving food security, and promoting sustainable agriculture are the main targets of sustainable development goals. It is well known that cropland resources are the most essential factor in achieving sustainable development goals. However, China has been facing the problem of a continuous reduction in cropland resources. Reducing the abandonment of cropland has become an important way to curb the reduction in cropland resources. Can agricultural machinery harvesting services reduce cropland abandonment in rural China? To answer this scientific question, this study employs the Survey for Agriculture and Village Economy data from 8345 samples of 12 provinces in rural China. The extended regression models (i.e., the extended probit regression model and the extended interval regression model) are used to empirically analyze the relationship between agricultural machinery harvesting services accessed by farmers and cropland abandonment. The results are as follows. Agricultural machinery harvesting services accessed by farmers significantly reduced the probability of cropland abandonment and the proportion of the area of abandoned cropland in farmers’ contracted cropland area decreased by 18.5% and 20.3%, respectively. Moreover, the heterogeneity analysis results showed that farmers’ access to agricultural machinery harvesting services significantly reduced cropland abandonment in small-scale groups, without elderly households, with nonagricultural income groups, and in the eastern region. This study also provides some policy implications for policymakers to reduce cropland abandonment in rural China

A secured energy future for the U.S.A : myth or truth?

Energy policies in the U.S. are ultimately shaped and influenced by changes in its surrounding economic and political landscapes. When Richard Nixon took over the presidential helms from his predecessor, the nation was at the start of a crucial transition point; the shift from a long era of cheaply abundant energy resources and environmental neglect to one of energy scarcity and a worrying growing dependence on foreign energy imports. U.S. had since 1967, lost its self-sufficiency in domestic petroleum capacity. Using the 4As - Availability (AV), Applicability (AP), Acceptability (AC) and Affordability (AF) as an evaluation framework, this study examines key energy policies implemented starting from the transition point of Nixon Administration in 1969 to the Bush Junior Administration.Bachelor of Art