3,042 research outputs found
2-[4-(BenzÂyloxy)benzylÂidene]malononitrile
In the title molÂecule, C17H12N2O, the dihedral angle between the two benzene rings is 84.98 (10)°. The dicyanoÂethylÂene group is coplanar with the benzene ring to which it is bonded. No classic hydrogen bonds were found in the crystal
High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration
High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration
High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration
rac-(S)-2-(1H-Imidazol-1-yl)-3-methylÂbutan-1-ol
In the crystal structure of the title compound, C8H14N2O, interÂmolecular O—H⋯N hydrogen bonds link molÂecules related by translation along the a axis into chains. Weak interÂmolecular C—H⋯O hydrogen bonds and C—H⋯π interÂactions enhance the crystal packing stability
Cocaine Hydrolase-Fc Fusion Proteins for Cocaine and Methods for Utilizing the Same
The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual
Study on Cloning and Expression Analysis of Cold Tolerance Genes in Different Fall Dormant Alfalfa
Multiwavelength Analysis of a Nearby Heavily Obscured AGN in NGC 449
We presented the multiwavelength analysis of a heavily obscured active
galactic nucleus (AGN) in NGC 449. We first constructed a broadband X-ray
spectrum using the latest NuSTAR and XMM-Newton data. Its column density
() and photon index () were
reliably obtained by analyzing the broadband X-ray spectrum. However, the
scattering fraction and the intrinsic X-ray luminosity could not be well
constrained. Combined with the information obtained from the mid-infrared
(mid-IR) spectrum and spectral energy distribution (SED) fitting, we derived
its intrinsic X-ray luminosity ()
and scattering fraction (). In addition, we also
derived the following results: (1). The mass accretion rate of central AGN is
about , and the Eddington ratio
is ; (2). The torus of this AGN has a high gas-to-dust
ratio ();
(3). The host galaxy and the central AGN are both in the early stage of
co-evolution.Comment: 12 pages, 5 figures, 3 tables, Accepted to PAS
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