68Ga-PSMA-11 PET/CT versus 68Ga-PSMA-11 PET/MRI for the detection of biochemically recurrent prostate cancer: a systematic review and meta-analysis

PurposeOur aim was to conduct a meta-analysis and systematic review in order to compare the diagnostic efficacy of 68Ga-PSMA-11 PET/CT and 68Ga-PSMA-11 PET/MRI in patients with biochemically recurrent after radical prostatectomy and biochemically recurrent prostate cancers (BCR) after hybrid RT and RP.MethodsUp until February 2023, we searched PubMed, Embase, and Web of Science for pertinent papers. Studies examining the utility of 68Ga-PSMA-11 PET/CT or PET/MRI as a screening tool for biochemically recurrent prostate cancer were included. To measure heterogeneity, we employed the I2 statistic. In cases of substantial heterogeneity (I2 > 50%), we used the random effect model to produce a forest plot. In other cases, we utilized the fixed model. Furthermore, we assessed the quality of the studies included using the Quality Assessment of Diagnostic Performance Studies (QUADAS-2) method.ResultsIn total, 37 studies involving 8409 patients were examined. For 68Ga-PSMA-11 PET/CT and 68Ga-PSMA-11 PET/MRI, the combined total detection rate was 0.70 (95% CI: 0.65-0.75) and 0.71 (95% CI:0.67-0.75), respectively. 68Ga-PSMA-11 PET/CT and 68Ga-PSMA-11 PET/MRI did not substantially differ in terms of the overall detection rate for BCR (P = 0.58). The detection rate was unaffected by the PSA values (all P > 0.05).ConclusionThe diagnostic efficacy of 68Ga-PSMA-11 PET/CT appears to be equivalent to that of 68Ga-PSMA-11 PET/MRI in detecting biochemically recurrent prostate cancer. Nonetheless, it should be noted that not all studies have used pathological biopsies as the gold standard. Therefore, additional larger prospective studies are needed to address this issue.Systematic review registrationidentifier CRD42023410039

Inhomogeneous microstructure and fatigue crack propagation of thick-section high strength steel joint welded using double-sided hybrid fiber laser-arc welding

The inhomogeneous microstructure and fatigue crack propagation of 30 mm thick-section high strength steel welded joint by double-sided hybrid fiber laser-arc welding were investigated in detail. The results indicated that the average effective grain size of the laser zone was only 1/2 of that of the arc zone, due to the faster cooling rate of the laser resource. The base metal consisted of massive polygonal ferrites and small granular carbides, while fine grained region, the coarse grained region and weld metal were all composed of martensite with a high dislocation density. Compared with the arc zone, the percentage of grain boundaries with high misorientation angle increased 24% for the laser zone, as the average grain size of the laser zone was smaller than that of the arc zone. The results also revealed that the fatigue crack propagation resistance of the welded joint was higher than that of the base metal. Meanwhile, a significant increase in the fatigue crack propagation resistance of the laser zone occurred, as compared with the arc zone, due to the refined grains and the high proportion of the grain boundaries with high misorientation angle (>15°) in the laser zone

A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H2S

Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H2S, a synchronizing change in fluorescence and nanochannel surface charge was established. As a result, both transmembrane ion current and fluorescence intensity showed significant changes. The photoelectric double-checked locking from temporal and spatial variation validly confirmed the response process and protected detection accuracy. The work may provide new ideas for the development of more sophisticated current and fluorescence dual-index nanochannel systems

Confining Fluorescent Probes in Nanochannels to Construct Reusable Nanosensors for Ion Current and Fluorescence Dual Gating

Here, we confined fluorescent probes to solid nanochannels to construct nanosensors, which not only significantly improved the reusability of the molecular probes, but also achieved ion current and fluorescence dual gating for more reliable detection. The combination of optical and electrical modalities can provide comprehensive spatiotemporal information that can be used to elucidate the sensing mechanism within the nanochannel. As a proof-of-concept experiment, fluorescein isothiocyanate (FITC)–hydrazine (N2H4) was selected to modify nanochannels for the effective detection of Hg2+. Based on spirolactam opening tactics, the system synergistically alters the surface charge and fluorescence intensity in response to Hg2+, establishing a dual open state of current and fluorescence. The newly prepared nanosensor exhibited a fast response (<1 min), high sensitivity, and selectivity towards Hg2+. Importantly, the nanodevice could be recovered by simple N2H4 treatment. Such sensing behavior could be used to implement optoelectronic dual-output XOR logical gates under the management of Hg2+ and N2H4. This strategy is anticipated to find broad applications in other nanochannel-based systems for various sensing applications used for monitoring of pollutants, food additives, and biomolecules

Rational Construction of a Mitochondria-Targeted Reversible Fluorescent Probe with Intramolecular FRET for Ratiometric Monitoring Sulfur Dioxide and Formaldehyde

Sulfur dioxide (SO2) and formaldehyde (FA) are important species that maintain redox homeostasis in life and are closely related to many physiological and pathological processes. Therefore, it is of great significance to realize the reversible monitoring of them at the intracellular level. Here, we synthesized a reversible ratiometric fluorescent probe through a reasonable design, which can sensitively monitor SO2 derivatives and FA, and the detection limit can reach 0.16 μM. The probe can specifically target mitochondria and successfully monitor the fluctuations of SO2 and FA in living cells. It also works well in the detection of SO2 and FA in zebrafish. This high-performance probe is expected to find broad in vitro and in vivo applications

Review on the research methods of the barrier and explosion-proof properties of porous materials

Barrier and explosion proof material can quickly transfer heat and block flame propagation, consequently prevent explosion accident. It is the essential safety technology to solve the problem of explosion or “secondary explosion” during the storage and transportation of flammable and explosive dangerous chemicals in liquid or gaseous state. Since the 1960s, the research at home and abroad on the barrier and explosion proof technology has been carried out mainly for the storage and transportation safety of fuel oil. It has been widely used in automobile fuel tank, fuel carrier, gas station, oil pipeline and aircraft fuel tank. In this paper, the research methods of barrier and explosion protection are reviewed, and the development of this technology in the future is prospected.Barrier and explosion proof material can quickly transfer heat and block flame propagation, consequently prevent explosion accident. It is the essential safety technology to solve the problem of explosion or “secondary explosion” during the storage and transportation of flammable and explosive dangerous chemicals in liquid or gaseous state. Since the 1960s, the research at home and abroad on the barrier and explosion proof technology has been carried out mainly for the storage and transportation safety of fuel oil. It has been widely used in automobile fuel tank, fuel carrier, gas station, oil pipeline and aircraft fuel tank. In this paper, the research methods of barrier and explosion protection are reviewed, and the development of this technology in the future is prospected

Study on Kinetics of Transesterification of Biodiesel in Zanthoxylum bungeanum seed Oil Ethyl Ester

Zanthoxylum bungeanum seed oil (ZSO) was the by-product of the zanthoxylum industry, and was a kind of cheap and abundant source in china, which can be great potential of use as a feedstock for biodiesel production in terms of reducing the producing cost. Kinetics of Transesterification of Biodiesel from Zanthoxylum bungeanum seed Oil Ethyl Ester using Sodium ethoxide as an alkaline catalyst was studied in this paper. The results showed that the progression of transesterification was grade 1.5, the reaction activation energy was 17.876kJ•mol-1 and the pre-exponential factor was 0.8521L/(mol•min). The contrast between experimental value and predicted value displayed the dynamics model had a good veracity, and can be applied for predicting reaction rate of progress

Switchable biomimetic nanochannels for on-demand SO2 detection by light-controlled photochromism

Conventional nanochannel sensors are passively responsive and may be slowly damaged by analytes present in the environment before detection. Here, authors developed a light-controlled inert/active-switchable biomimetic nanochannel sensor to achieve SO2 on-demand detection and long-term preservation