Research on Optimization for Passenger Streamline of Hubs

AbstractThis paper proposes an optimization model for passenger streamline to promote the organization of hub management. Passengers are divided into two different categories, namely familiar type and unfamiliar type. Then the different route choice behaviors of these two types are analyzed. The graph theory is employed to abstract the hub network. The system cost is taken as the optimization objective, and then an optimization design model for passenger streamline is built. To find a solution, we adopt a traversal search algorithm to enumerate all the possible schemes, and then choose the scheme with the minimum system cost. Finally, a simple case is taken to verify the validity of the proposed model

Impact of Road Bends on Traffic Flow in a Single-Lane Traffic System

Taking the characteristics of road bends as a research object, this work proposes the cellular model (CA) with road bends based on the NaSch model, with which the traffic flow is examined under different conditions, such as bend radius, bend arc length, and road friction coefficiency. The simulation results show that, with the increase of the bend radius, the peak flow will be continuously increased, and the fundamental diagram will become more similar to that of the classic NaSch model; the smaller the bend radius is, the easier it is for the occurrence of blockage; for different bend lengths, all the corresponding traffic flows show that the phenomenon of go-and-stop and the bends exert slight inhibitory effect on traffic flow; under the same bend radius, the inhibition effect of the bends on the traffic flow will be weakened with the increase of the friction coefficiency

Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

Abstract AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate cancer cells and its overexpression correlates with AKT phosphorylation in patient samples. HDAC3 facilitates lysine‐63‐chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1. Conditional homozygous deletion of Hdac3 suppresses prostate tumorigenesis and progression by concomitant blockade of AKT and AR signaling in the Pten knockout mouse model. Pharmacological inhibition of HDAC3 using a selective HDAC3 inhibitor RGFP966 inhibits growth of both PTEN‐deficient and SPOP‐mutated prostate cancer cells in culture, patient‐derived organoids and xenografts in mice. Our study identifies HDAC3 as a common upstream activator of AKT and AR signaling and reveals that dual inhibition of AKT and AR pathways is achievable by single‐agent targeting of HDAC3 in prostate cancer

Combinational Scheduling Model Considering Multiple Vehicle Sizes

Urban public transport is an effective way to solve urban traffic problems and promote sustainable development of urban traffic. A scientific operation scheduling system has an important guiding significance for optimizing the configuration of urban public transport capacity resources, improving the level of operation organization and management, and providing for the sustainability of the transportation system. According to the inhomogeneous distribution of passenger flow along transit lines, this study develops a combinational scheduling model in which the enterprise supplies zonal service based on regular service. The objective function minimizes the sum of passenger travel cost and operation cost, and the simulated annealing algorithm is designed to solve the optimization model. This paper abstracts an ideal example by taking a real-world case of Bus Line 131 in Lanzhou, China. The numerical example is used to verify the validity of the model and algorithm. Results show that the combinational operation scheme can effectively satisfy passengers’ demand and reduce the total cost by 7.03% in comparison with the regular operation system. The optimal combinational system with the lowest total cost can increase the vehicle load factor and improve the utilization ratio

Using Fourier Transform Infrared Spectroscopy to Study Effects of Magnetic Field Treatment on Wheat (Triticum aestivum L.) Seedlings

Magnetic field treatments have been utilized to promote germination and growth of a variety of species of plants; however the mechanism of concern has not been fully elucidated. In this research, wheat seedlings were treated with 500 mT and 1500 mT static magnetic field (SMF) for 10 and 20 min, respectively. Analyzing Fourier transform infrared spectra collected from leaves of seedlings showed that SMF treatments decreased the contents of lipids and proteins, shifted bands to higher wavenumbers in 3000–2800 cm−1 regions, and increased the ratio of CH2/CH3 which likely indicates a structural variation of lipids. For bands assigned to different second structures of proteins, slight bands shifting and changing the ratio of different second structures of proteins were observed due to SMF treatments. To summarize, the results revealed that lipids rather than proteins were sensitive to SMF treatments. The results provided insight into the SMF induced conformational changes of lipids and proteins in wheat leaves, which will help elucidate the biological mechanisms of SMF on plant growth and development

Theory and Simulation for Traffic Characteristics on the Highway with a Slowdown Section

We study the traffic characteristics on a single-lane highway with a slowdown section using the deterministic cellular automaton (CA) model. Based on the theoretical analysis, the relationships among local mean densities, velocities, traffic fluxes, and global densities are derived. The results show that two critical densities exist in the evolutionary process of traffic state, and they are significant demarcation points for traffic phase transition. Furthermore, the changing laws of the two critical densities with different length of limit section are also investigated. It is shown that only one critical density appears if a highway is not slowdown section; nevertheless, with the growing length of slowdown section, one critical density separates into two critical densities; if the entire highway is slowdown section, they finally merge into one. The contrastive analysis proves that the analytical results are consistent with the numerical ones

C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity

10.1124/mol.113.087155Molecular Pharmacology844643-653MOPM

Comparative analysis for traffic flow forecasting models with real-life data in Beijing

Rational traffic flow forecasting is essential to the development of advanced intelligent transportation systems. Most existing research focuses on methodologies to improve prediction accuracy. However, applications of different forecast models have not been adequately studied yet. This research compares the performance of three representative prediction models with real-life data in Beijing. They are autoregressive integrated moving average, neutral network, and nonparametric regression. The results suggest that nonparametric regression significantly outperforms the other models. With Wilcoxon signed-rank test, the root mean square errors and the error distribution reveal that the nonparametric regression model experiences superior accuracy. In addition, the nonparametric regression model exhibits the best spatial-transferred application effect