Treatment of juxtafoveal central serous chorioretinopathy by compound anisodine injection

AIM: To investigate the efficiency and security of compound anisodine injection in the treatment of juxtafoveal central serous chorioretinopathy(CSC). <p>METHODS: Sixty patients(60 eyes)who were diagnosed of juxtafoveal CSC were assigned randomly into 2 groups: 32 cases(32 eyes, therapeutic group)were injected subcutaneously compound anisodine injection for 2mL q.d around superficial temporal arteries in the affected eyes; 28 cases(28 eyes, control group)received only traditional oral medication. Both groups received therapy for 2 to 4 courses of treatment. The main observations were the best corrected visual acuity(BCVA), subjective symptom, visual field, average light sensitivity and optical coherent topography(OCT).<p>RESULTS: There was no significant difference between the therapeutic group and the control group before treatment(<i>P</i>>0.05), but all the outcome measures at 1, 3mo in the treatment group were significantly improved as compared with control group(<i>P</i><0.05). After 6mo, there were no significant difference between the two groups in all measures(<i>P</i>>0.05). No severe adverse reaction was noted except mild ones such as temporary dry mouth, dizziness and palpitation in a few cases.<p>CONCLUSION: Compound anisodine injection has remarkable effects in the treatment of juxtafoveal CSC. It can shorten the course, improved the visual function and decreased the recurrence rate of CSC

Vehicular Fog Computing Enabled Real-time Collision Warning via Trajectory Calibration

Vehicular fog computing (VFC) has been envisioned as a promising paradigm for enabling a variety of emerging intelligent transportation systems (ITS). However, due to inevitable as well as non-negligible issues in wireless communication, including transmission latency and packet loss, it is still challenging in implementing safety-critical applications, such as real-time collision warning in vehicular networks. In this paper, we present a vehicular fog computing architecture, aiming at supporting effective and real-time collision warning by offloading computation and communication overheads to distributed fog nodes. With the system architecture, we further propose a trajectory calibration based collision warning (TCCW) algorithm along with tailored communication protocols. Specifically, an application-layer vehicular-to-infrastructure (V2I) communication delay is fitted by the Stable distribution with real-world field testing data. Then, a packet loss detection mechanism is designed. Finally, TCCW calibrates real-time vehicle trajectories based on received vehicle status including GPS coordinates, velocity, acceleration, heading direction, as well as the estimation of communication delay and the detection of packet loss. For performance evaluation, we build the simulation model and implement conventional solutions including cloud-based warning and fog-based warning without calibration for comparison. Real-vehicle trajectories are extracted as the input, and the simulation results demonstrate that the effectiveness of TCCW in terms of the highest precision and recall in a wide range of scenarios

Deep Item-based Collaborative Filtering for Top-N Recommendation

Item-based Collaborative Filtering(short for ICF) has been widely adopted in recommender systems in industry, owing to its strength in user interest modeling and ease in online personalization. By constructing a user's profile with the items that the user has consumed, ICF recommends items that are similar to the user's profile. With the prevalence of machine learning in recent years, significant processes have been made for ICF by learning item similarity (or representation) from data. Nevertheless, we argue that most existing works have only considered linear and shallow relationship between items, which are insufficient to capture the complicated decision-making process of users. In this work, we propose a more expressive ICF solution by accounting for the nonlinear and higher-order relationship among items. Going beyond modeling only the second-order interaction (e.g. similarity) between two items, we additionally consider the interaction among all interacted item pairs by using nonlinear neural networks. Through this way, we can effectively model the higher-order relationship among items, capturing more complicated effects in user decision-making. For example, it can differentiate which historical itemsets in a user's profile are more important in affecting the user to make a purchase decision on an item. We treat this solution as a deep variant of ICF, thus term it as DeepICF. To justify our proposal, we perform empirical studies on two public datasets from MovieLens and Pinterest. Extensive experiments verify the highly positive effect of higher-order item interaction modeling with nonlinear neural networks. Moreover, we demonstrate that by more fine-grained second-order interaction modeling with attention network, the performance of our DeepICF method can be further improved.Comment: 25 pages, submitted to TOI

Simulation of Transients in Natural Gas Networks via A Semi-analytical Solution Approach

Simulation and control of the transient flow in natural gas networks involve solving partial differential equations (PDEs). This paper proposes a semi-analytical solutions (SAS) approach for fast and accurate simulation of the natural gas transients. The region of interest is divided into a grid, and an SAS is derived for each grid cell in the form of the multivariate polynomials, of which the coefficients are identified according to the initial value and boundary value conditions. The solutions are solved in a ``time-stepping'' manner; that is, within one time step, the coefficients of the SAS are identified and the initial value of the next time step is evaluated. This approach achieves a much larger grid cell than the widely used finite difference method, and thus enhances the computational efficiency significantly. To further reduce the computation burden, the nonlinear terms in the model are simplified, which induces another SAS scheme that can greatly reduce the time consumption and have minor impact on accuracy. The simulation results on a single pipeline case and a 6-node network case validate the advantages of the proposed SAS approach in accuracy and computational efficiency