Assessment of diagnostic value of age for meridional amblyopia with Logistic regression and receiver operating characteristic curve

AIM: To assess the diagnostic value of age for meridional amblyopia by Logistic regression and receiver operating characteristic(ROC)curve.<p>METHODS: A total of 1 005 children(1 910 eyes)with unknown ocular abnormalities other than with-the-rule astigmatism(aged 4-8 years)were recruited. Astigmatism >or =1.00D and sphere < or = 3.00D were present in one or both eyes. The difference of sphere between both eyes was less 1.50D. The difference of astigmatism between both eyes was less 1.00D. All astigmatism was calculated by the absolute value. By analyzing age, sex, astigmatism type, diopter of cylinder and diopter of sphere with Logistic regression, two mathematical models were established. Then the diagnostic efficacy of the model was assessed using the ROC curve.<p>RESULTS: The model 1 included 4 parameters(sex, astigmatism type, diopter of cylinder and diopter of sphere). The model 2 included 5 parameters(the 4 parameters of the model 1 adding age). Using Logistic regression, the diopter of cylinder had an influence on the diagnosis of meridional amblyopia in two models. In model 2, age was another influencing factor on the diagnosis of meridional amblyopia. The model 1 area under ROC curve(AUC)was 0.64, and the model 2 was 0.74. The area of model 2 was greater than the model 1. There was statistical difference in the AUC of two models(<i>P</i><0.05).<p>CONCLUSION: Age might be an influential factor on the diagnosis of meridional amblyopia using Logistic regression and ROC curve

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: A systematic review and meta-analysis

Abstract Background The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases. Methods Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Results 4373 NSCLC patients with brain metastases in 18 studies were involved. Mutated EGFR associated with significantly improved OS compared with wild type. Subgroup analyses suggested that this relationship persisted in studies conducted in Eastern, with retrospective design, with sample size ≥500, mean age of patients ≥65.0 years, percentage male < 50.0%, percentage of patients receiving tyrosine kinase inhibitor ≥30.0%. Finally, although significant publication bias was observed using the Egger test, the results were not changed after adjustment using the trim and fill method. Conclusions This meta-analysis suggests that EGFR mutation is an important predictive factor linked to improved OS for NSCLC patients with brain metastases. It can serve as a useful index in the prognostic assessment of NSCLC patients with brain metastases

Based on Two and Three Dimensional Technology to quickly build a Virtual Battlefield

AbstractVirtual battlefield environment is the use of computer technology, graphics technology and virtual reality technology to the real battle space in the computer. As technology advances and development, virtual battlefield environment system has been applied more and more combat troops and combat command being. Virtual Battlefield Environment Simulation System is a system for the commander to provide a realistic battlefield environment to facilitate their understanding of the terrain, the battlefield awareness information. In this paper, two-dimensional battlefield maps based on MapObject structures and the construction of three-dimensional virtual battlefield environment problem, a second, three-dimensional virtual battlefield environment with the rapid construction techniques. Operational commanders can quickly build a virtual battlefield, not only from the macro real-time battlefield information and to grasp the battlefield situation, but also learned from the battlefield of detailed microscopic details

catena-Poly[[aqua­(dipyrido[3,2-a:2′,3′-c]phenazine-κ2 N 4,N 5)iron(II)]-μ-pyrazine-2,3-dicarboxyl­ato-κ3 N 1,O 2:O 3]

In the title compound, [Fe(C6H2N2O4)(C18H10N4)(H2O)]n, the FeII ion adopts a slightly distorted octahedral mer-FeN3O3 geometry, arising from one N,N′-bidentate dipyrido[3,2-a:2′,3′-c]phenazine ligand, one N,O-chelating pyrazine-2,3-dicarboxyl­ate dianion and one water mol­ecule. An O-bonded symmetry-related dianion completes the coordination of the metal. The bridging dianion results in a one-dimensional polymeric chain. Aromatic π–π stacking inter­actions between ligands [centroid–centroid separations = 3.528 (2) and 3.741 (2) Å] and O—H⋯O and O—H⋯N hydrogen bonds link the chains together, leading to a three-dimensional supra­molecular network

catena-Poly[[aqua­(pyrazino[2,3-f][1,10]phenanthroline-κ2 N 8,N 9)cobalt(II)]-μ-pyrazine-2,3-dicarboxyl­ato-κ3 N 1 O 2:O 3]

In the title compound, [Co(C6H2N2O4)(C14H8N4)(H2O)]n, the Co atom is bonded to one N,N′-bidentate pyrazino[2,3-f][1,10]phenanthroline (Pyphen) ligand, one N,O-bidentate pyrazine-2,3-dicarboxyl­ate (PZDC) dianion and one water mol­ecule in a distorted octa­hedral mer-CoN3O3 geometry. The CoII atoms are bridged by the PZDC dianions, forming an infinite one-dimensional chain running along the b axis. Adjacent chains pack together through π–π stacking inter­actions [centroid–centroid separations = 3.498 (4) and 3.528 (4) Å], and O—H⋯O and O—H⋯N hydrogen bonds involving the water mol­ecule complete the structure