YOLO-FaceV2: A Scale and Occlusion Aware Face Detector

In recent years, face detection algorithms based on deep learning have made great progress. These algorithms can be generally divided into two categories, i.e. two-stage detector like Faster R-CNN and one-stage detector like YOLO. Because of the better balance between accuracy and speed, one-stage detectors have been widely used in many applications. In this paper, we propose a real-time face detector based on the one-stage detector YOLOv5, named YOLO-FaceV2. We design a Receptive Field Enhancement module called RFE to enhance receptive field of small face, and use NWD Loss to make up for the sensitivity of IoU to the location deviation of tiny objects. For face occlusion, we present an attention module named SEAM and introduce Repulsion Loss to solve it. Moreover, we use a weight function Slide to solve the imbalance between easy and hard samples and use the information of the effective receptive field to design the anchor. The experimental results on WiderFace dataset show that our face detector outperforms YOLO and its variants can be find in all easy, medium and hard subsets. Source code in https://github.com/Krasjet-Yu/YOLO-FaceV

A BAC-Based Physical Map of Zhikong Scallop (Chlamys farreri Jones et Preston)

Zhikong scallop (Chlamys farreri) is one of the most economically important aquaculture species in China. Physical maps are crucial tools for genome sequencing, gene mapping and cloning, genetic improvement and selective breeding. In this study, we have developed a genome-wide, BAC-based physical map for the species. A total of 81,408 clones from two BAC libraries of the scallop were fingerprinted using an ABI 3130xl Genetic Analyzer and a fingerprinting kit developed in our laboratory. After data processing, 63,641 (∼5.8× genome coverage) fingerprints were validated and used in the physical map assembly. A total of 3,696 contigs were assembled for the physical map. Each contig contained an average of 10.0 clones, with an average physical size of 490 kb. The combined total physical size of all contigs was 1.81 Gb, equivalent to approximately 1.5 fold of the scallop haploid genome. A total of 10,587 BAC end sequences (BESs) and 167 markers were integrated into the physical map. We evaluated the physical map by overgo hybridization, BAC-FISH (fluorescence in situ hybridization), contig BAC pool screening and source BAC library screening. The results have provided evidence of the high reliability of the contig physical map. This is the first physical map in mollusc; therefore, it provides an important platform for advanced research of genomics and genetics, and mapping of genes and QTL of economical importance, thus facilitating the genetic improvement and selective breeding of the scallop and other marine molluscs

Long-term efficacy of hydrotherapy on balance function in patients with Parkinson’s disease: a systematic review and meta-analysis

BackgroundHydrotherapy can improve the motor and non-motor symptoms of Parkinson’s disease (PD), but the long-term effects of hydrotherapy on PD are still unclear.ObjectiveThe purpose of this systematic evaluation and meta-analysis was to explore the long-term effects of hydrotherapy on balance function in PD patients.MethodsA systematic search of five databases was conducted to identify appropriate randomized controlled trials (RCTs) according to the established inclusion and exclusion criteria. The general characteristics and outcome data (balance, exercise, mobility, quality of life, etc.) of the included studies were extracted, and the quality of the included studies was evaluated using the Cochrane risk of bias assessment tool. Finally, the outcome data were integrated for meta-analysis.ResultsA total of 149 articles were screened, and 5 high-quality RCTs involving 135 PD patients were included. The results of the meta-analysis showed positive long-term effects of hydrotherapy on balance function compared to the control group (SMD = 0.69; 95% CI = 0.21, 1.17; p = 0.005; I2 = 44%), However, there were no significant long-term effects of hydrotherapy on motor function (SMD = 0.06; 95% CI = −0.33, 0.44; p = 0.77; I2 = 0%), mobility and quality of life (SMD = −0.21; 95% CI = −0.98, 0.57; p = 0.6; I2 = 71%). Interestingly, the results of the sensitivity analysis performed on mobility showed a clear continuation effect of hydrotherapy on mobility compared to the control group (SMD = −0.80; 95% CI = −1.23, −0.37; p < 0.001; I2 = 0%).ConclusionThe long-term effects of hydrotherapy on PD patients mainly focus on balance function, and the continuous effects on motor function, mobility, and quality of life are not obvious

Gender Dependence for a Subset of the Low-Abundance Signaling Proteome in Human Platelets

The incidence of cardiovascular diseases is ten-times higher in males than females, although the biological basis for this gender disparity is not known. However, based on the fact that antiplatelet drugs are the mainstay for prevention and therapy, we hypothesized that the signaling proteomes in platelets from normal male donors might be more activated than platelets from normal female donors. We report here that platelets from male donors express significantly higher levels of signaling cascade proteins than platelets from female donors. In silico connectivity analysis shows that the 24 major hubs in platelets from male donors focus on pathways associated with megakaryocytic expansion and platelet activation. By contrast, the 11 major hubs in platelets from female donors were found to be either negative or neutral for platelet-relevant processes. The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease