Exceptional representations of a double quiver of type A, and Richardson elements in seaweed Lie algebras

In this paper, we study the set of $\Delta$-filtered modules of quasi-hereditary algebras arising from quotients of the double of quivers of type $A$. Our main result is that for any fixed $\Delta$-dimension vector, there is a unique (up to isomorphism) exceptional $\Delta$-filtered module. We then apply this result to show that there is always an open adjoint orbit in the nilpotent radical of a seaweed Lie algebra in \mathrm{gl}_{n}(\field), thus answering positively in this \mathrm{gl}_{n}(\field) case to a question raised independently by Michel Duflo and Dmitri Panyushev. An example of a seaweed Lie algebra in a simple Lie algebra of type $E_{8}$ not admitting an open orbit in its nilpotent radical is given

Monitoring Land Surface Deformation with Satellite ScanSAR Images: Case Studies on Large Earthquakes in China

This chapter presents a new application of scanning interferometric synthetic aperture radar (ScanSAR) interferometry in monitoring land surface deformation caused by large earthquakes. To make better use of the ScanSAR data and obtain a wider deformation observation, this research studied and analyzed certain key elements of ScanSAR interferometry, including coherence, co-registering, methods of removing orbit errors, correction of atmosphere effects, and geoid undulation. The wide swath mode (WSM) is also known as the ScanSAR mode by which synthetic aperture time is shared by adjacent sub-swaths and azimuth resolution that is traded off for a wider coverage. So, it is possible to monitor a larger area of earthquake deformation. In this study, we obtained ScanSAR and Image Mode (IM) data and analyzed coherence, co-registering, methods of removing orbit errors, correction of atmosphere effects, and geoid undulation to monitor land surface deformation caused by large earthquakes in the 405 × 405 km field of the Wenchuan earthquake and Yutian earthquake, respectively, in China. The results obtained agree well with that of the investigations of the crustal motion in the study areas

Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis

<p>Abstract</p> <p>Background</p> <p>Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis, remodeling of extracellular matrix, and tumor metastasis. Ets-1 target genes involved in various stages of new blood vessel formation include angiopoietin, matrix metalloproteinases (MMPs) and the protease inhibitor maspin.</p> <p>Methods</p> <p>We used immunohistochemistry (IHC) to detect the expression of Ets-1, angiopoietin-2 (Ang-2) and maspin in ovarian tumor and analyzed the relationship between the expression of these proteins and the clinical manifestation of ovarian cancer.</p> <p>Results</p> <p>Ets-1 expression was much stronger in ovarian cancer compared to benign tumors, but had no significant correlation with other pathological parameters of ovarian cancer. However, Ang-2 and maspin expression had no obvious correlation with pathological parameters of ovarian cancer. Ets-1 had a positive correlation with Ang-2 which showed their close relationship in angiogenesis. Although microvessel density (MVD) value had no significant correlation with the expression of Ets-1, Ang-2 or maspin, strong nuclear expression of maspin appeared to be correlated with high grade and MVD.</p> <p>Conclusions</p> <p>The expression of Ets-1, Ang2 and maspin showed close relationship with angiogenesis in ovarian cancer and expression of maspin appeared to be correlated with high grade and MVD. The mechanisms underlying the cross-talk of the three factors need further investigations.</p

Thermodynamic and kinetic study of CO2 adsorption/desorptionon amine-functionalized sorbents

The thermodynamic and kinetic characteristics of CO2 adsorption of SBA-16 loaded with pentaethylenehexamine (PEHA) have been investigated using adsorption column system. The Langmuir isotherm model fitts the CO2 adsorption isotherms well, and the average isosteric heat of adsorption is 59.6 kJ/mol, indicating that the CO2 adsorption on PEHA-loaded SBA-16 is chemisorption. The Avrami fractional dynamics model is very suitable for illustrating the adsorption behaviour of CO2 adsorption, and the results of kinetic analysis show that increasing the partial pressure of CO2 or the working temperature is beneficial to the adsorption of CO2. Three desorption methods were evaluatedto achieve the optimal desorption method. The results show that VTSA and steam stripping method are effective methods for industrial CO2 desorption. Steam stripping may be more suitable for plants that already have low-cost steam. The activation energy Ea of CO2 adsorption/desorption is calculated using Arrhenius equation. The activation energy Ea of CO2 adsorption/desorption was calculated using the Arrhenius equation. The results show that the absolute value of Ea (adsorption) decreases with the increase of CO2 partial pressure. In addition, the Ea value of vacuum rotary regeneration method and steam stripping method is smaller than the Ea value of temperature swing regeneration

Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood. Methods: The expression of GOLPH3 and Wntless (Wls) in glioma tissues was examined by western blotting and immunohistochemistry. EdU incorporation assay and colony formation assay was used to examine the cell growth ability. The effect of GOLPH3 on Wls recycling, Wnt secretion and β-catenin activity was detected using western blotting, immunofluorescence, RT-PCR, ELISA or luciferase assay. Results: The protein levels of GOLPH3 and Wls were upregulated and positively correlated with each other in human glioma tissues. The promoting effect of GOLPH3 on glioma cell proliferation was partially mediated by Wls. In addition, GOLPH3 interacted with Wls and GOLPH3 down-regulation drove Wls into lysosome for degradation, inhibiting its recycling to golgi and the plasma membrane. Importantly, GOLPH3 down-regulation inhibited Wnt2b secretion and decreased β-catenin level and transcription activity. Conclusions: This study provides a brand new evidence that GOLPH3 promotes glioma cell proliferation by facilitating Wls recycling and Wnt/β-catenin signaling. Our findings suggest a rationale for targeting the GOLPH3-Wls-Wnt axis as a promising therapeutic approach for glioblastoma

A Role for a Dioxygenase in Auxin Metabolism and Reproductive Development in Rice

SummaryIndole-3-acetic acid (IAA), the natural auxin in plants, regulates many aspects of plant growth and development. Extensive analyses have elucidated the components of auxin biosynthesis, transport, and signaling, but the physiological roles and molecular mechanisms of auxin degradation remain elusive. Here, we demonstrate that the dioxygenase for auxin oxidation (DAO) gene, encoding a putative 2-oxoglutarate-dependent-Fe (II) dioxygenase, is essential for anther dehiscence, pollen fertility, and seed initiation in rice. Rice mutant lines lacking a functional DAO display increased levels of free IAA in anthers and ovaries. Furthermore, exogenous application of IAA or overexpression of the auxin biosynthesis gene OsYUCCA1 phenocopies the dao mutants. We show that recombinant DAO converts the active IAA into biologically inactive 2-oxoindole-3-acetic acid (OxIAA) in vitro. Collectively, these data support a key role of DAO in auxin catabolism and maintenance of auxin homeostasis central to plant reproductive development