Clinical Study Recombinant Brain Natriuretic Peptide for the Prevention of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Nonemergent Percutaneous Coronary Intervention or Coronary Angiography: A Randomized Controlled Tria

The role of brain natriuretic peptide (BNP) in the prevention of contrast-induced nephropathy (CIN) is unknown. This study aimed to investigate BNP's effect on CIN in chronic kidney disease (CKD) patients undergoing elective percutaneous coronary intervention (PCI) or coronary angiography (CAG). The patients were randomized to BNP (0.005 g/kg/min before contrast media (CM) exposure and saline hydration, = 106) or saline hydration alone ( = 103). Cystatin C, serum creatinine (SCr) levels, and estimated glomerular filtration rates (eGFR) were assessed at several time points. The primary endpoint was CIN incidence; secondary endpoint included changes in cystatin C, SCr, and eGFR. CIN incidence was significantly lower in the BNP group compared to controls (6.6% versus 16.5%, = 0.025). In addition, a more significant deterioration of eGFR, cystatin C, and SCr from 48 h to 1 week ( < 0.05) was observed in controls compared to the BNP group. Although eGFR gradually deteriorated in both groups, a faster recovery was achieved in the BNP group. Multivariate logistic regression revealed that using >100 mL of CM (odds ratio: 4.36, = 0.004) and BNP administration (odds ratio: 0.21, = 0.006) were independently associated with CIN. Combined with hydration, exogenous BNP administration before CM effectively decreases CIN incidence in CKD patients

Cooperative Efficiency Evaluation System for Intelligent Transportation Facilities Based on the Variable Weight Matter Element Extension

In order to effectively evaluate the cooperative efficiency of intelligent transportation facilities, a structural model of four cooperative development elements, including functional cooperative, operational cooperative, information cooperative, and operation cooperative, is constructed with the guidance of system coordination and a cooperative efficiency evaluation system is established based on it. Then, a dynamic efficiency evaluation model based on variable weight and matter-element extension method was constructed to describe the cooperative efficiency of intelligent transportation facilities and analyze the cooperative efficiency of key road sections in the Jinan area as an example. The results show that of the ten sections, two are in poor performance status, three are in good performance status, and five are in excellent performance status. The four indexes of vertical cooperative construction, functional scheduling level, information element completeness, and multi-departmental information integration level have the most significant impact on facility cooperative efficiency and are the most sensitive; the three indexes of plan executability, functional ease of upgrading, and space–time alignment rate have the most negligible impact on facility cooperative efficiency and are the least sensitive

Cooperative Efficiency Evaluation System for Intelligent Transportation Facilities Based on the Variable Weight Matter Element Extension

In order to effectively evaluate the cooperative efficiency of intelligent transportation facilities, a structural model of four cooperative development elements, including functional cooperative, operational cooperative, information cooperative, and operation cooperative, is constructed with the guidance of system coordination and a cooperative efficiency evaluation system is established based on it. Then, a dynamic efficiency evaluation model based on variable weight and matter-element extension method was constructed to describe the cooperative efficiency of intelligent transportation facilities and analyze the cooperative efficiency of key road sections in the Jinan area as an example. The results show that of the ten sections, two are in poor performance status, three are in good performance status, and five are in excellent performance status. The four indexes of vertical cooperative construction, functional scheduling level, information element completeness, and multi-departmental information integration level have the most significant impact on facility cooperative efficiency and are the most sensitive; the three indexes of plan executability, functional ease of upgrading, and space–time alignment rate have the most negligible impact on facility cooperative efficiency and are the least sensitive

Correction: Li et al. Cooperative Efficiency Evaluation System for Intelligent Transportation Facilities Based on the Variable Weight Matter Element Extension. <em>Sustainability</em> 2023, <em>15</em>, 2411

The authors would like to make the following corrections about the published paper [...

Recombinant Brain Natriuretic Peptide for the Prevention of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Nonemergent Percutaneous Coronary Intervention or Coronary Angiography: A Randomized Controlled Trial

The role of brain natriuretic peptide (BNP) in the prevention of contrast-induced nephropathy (CIN) is unknown. This study aimed to investigate BNP’s effect on CIN in chronic kidney disease (CKD) patients undergoing elective percutaneous coronary intervention (PCI) or coronary angiography (CAG). The patients were randomized to BNP (0.005 μg/kg/min before contrast media (CM) exposure and saline hydration, n=106) or saline hydration alone (n=103). Cystatin C, serum creatinine (SCr) levels, and estimated glomerular filtration rates (eGFR) were assessed at several time points. The primary endpoint was CIN incidence; secondary endpoint included changes in cystatin C, SCr, and eGFR. CIN incidence was significantly lower in the BNP group compared to controls (6.6% versus 16.5%, P=0.025). In addition, a more significant deterioration of eGFR, cystatin C, and SCr from 48 h to 1 week (P<0.05) was observed in controls compared to the BNP group. Although eGFR gradually deteriorated in both groups, a faster recovery was achieved in the BNP group. Multivariate logistic regression revealed that using >100 mL of CM (odds ratio: 4.36, P=0.004) and BNP administration (odds ratio: 0.21, P=0.006) were independently associated with CIN. Combined with hydration, exogenous BNP administration before CM effectively decreases CIN incidence in CKD patients